No Cover Image

Journal article 457 views 47 downloads

Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions

Mads Damkjaer Orcid Logo, Maria Loane, Stine Kjær Urhøj, Elisa Ballardini, Clara Cavero- Carbonell Orcid Logo, Alessio Coi, Laura García-Villodre, Joanne Emma Given Orcid Logo, Mika Gissler, Anna Heino, Sue Jordan Orcid Logo, Amanda Neville, Anna Pierini, Joachim Tan, Ieuan Scanlon, Ester Garne Orcid Logo, Joan K Morris Orcid Logo

BMJ Open, Volume: 12, Issue: 10, Start page: e061746

Swansea University Authors: Sue Jordan Orcid Logo, Ieuan Scanlon

  • 61953.pdf

    PDF | Version of Record

    This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license

    Download (971.09KB)

Abstract

Objectives Preterm children are exposed to many medications in neonatal intensive care units, but little is known about the effect of prematurity on medication use throughout infancy and childhood. We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthma...

Full description

Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa61953
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Objectives Preterm children are exposed to many medications in neonatal intensive care units, but little is known about the effect of prematurity on medication use throughout infancy and childhood. We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthmatic medication and antibiotics issued/dispensed in the first 10 years of life for very and moderately preterm children compared with term.Design Population-based data linkage cohort study linking information from birth records to prescription records.Setting Six registries from five countries in the EUROlinkCAT study.Participants The study population included 1 722 912 children, of whom 10 820 (0.6%) were very preterm (<32 weeks gestational age (GA)), 92 814 (5.4%) were moderately preterm (32–36 weeks GA), 1 606 643 (93.3%) were born at term (≥37 weeks GA) and 0.7% had missing GA. Children with major or minor congenital anomalies were excluded (including patent ductus arteriosus).Main outcome measures Relative risk (RR) of receiving a prescription for CVM, ASM, antiasthmatic and antibiotics.Results Very preterm children had a higher RR of receiving a prescription for CVM and ASM than preterm children. For all preterm children, the RR of having a CVM prescription was 3.58 (95% CI 2.06 to 6.23); 2.06 (95% CI 1.73 to 2.41) for ASM; 1.13 (95% CI 0.99 to 1.29) for antiasthmatics and 0.96 (95% CI 0.93 to 0.99) for antibiotics in the first year of life. Increased prescription of CVM, ASM and antiasthmatics persisted for all 10 years of follow-up. Although the RR was highest for CVM and ASM, in absolute numbers more children received prescriptions for antibiotics (42.34%, 95% CI 38.81% to 45.91%) and antiasthmatics (28.40%, 95% CI 16.07% to 42.649%) than for CVM (0.18%, 95% CI 0.12% to 0.25%) and ASM (0.16%, 95% CI 0.13% to 0.20%) in the first year of life.Conclusion Preterm children had a higher risk of being prescribed/dispensed CVM, ASM and antiasthmatics up to age 10. This study highlights a need for further research into morbidity beyond age 10.
College: Faculty of Medicine, Health and Life Sciences
Funders: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 733001.
Issue: 10
Start Page: e061746