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Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions

Mads Damkjaer Orcid Logo, Maria Loane, Stine Kjær Urhøj, Elisa Ballardini, Clara Cavero- Carbonell Orcid Logo, Alessio Coi, Laura García-Villodre, Joanne Emma Given Orcid Logo, Mika Gissler, Anna Heino, Sue Jordan Orcid Logo, Amanda Neville, Anna Pierini, Joachim Tan, Ieuan Scanlon, Ester Garne Orcid Logo, Joan K Morris Orcid Logo

BMJ Open, Volume: 12, Issue: 10, Start page: e061746

Swansea University Authors: Sue Jordan Orcid Logo, Ieuan Scanlon

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DOI (Published version): 10.1136/bmjopen-2022-061746

Abstract

Objectives Preterm children are exposed to many medications in neonatal intensive care units, but little is known about the effect of prematurity on medication use throughout infancy and childhood. We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthma...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2022
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We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthmatic medication and antibiotics issued/dispensed in the first 10 years of life for very and moderately preterm children compared with term.Design Population-based data linkage cohort study linking information from birth records to prescription records.Setting Six registries from five countries in the EUROlinkCAT study.Participants The study population included 1 722 912 children, of whom 10 820 (0.6%) were very preterm (&lt;32 weeks gestational age (GA)), 92 814 (5.4%) were moderately preterm (32–36 weeks GA), 1 606 643 (93.3%) were born at term (≥37 weeks GA) and 0.7% had missing GA. Children with major or minor congenital anomalies were excluded (including patent ductus arteriosus).Main outcome measures Relative risk (RR) of receiving a prescription for CVM, ASM, antiasthmatic and antibiotics.Results Very preterm children had a higher RR of receiving a prescription for CVM and ASM than preterm children. For all preterm children, the RR of having a CVM prescription was 3.58 (95% CI 2.06 to 6.23); 2.06 (95% CI 1.73 to 2.41) for ASM; 1.13 (95% CI 0.99 to 1.29) for antiasthmatics and 0.96 (95% CI 0.93 to 0.99) for antibiotics in the first year of life. Increased prescription of CVM, ASM and antiasthmatics persisted for all 10 years of follow-up. Although the RR was highest for CVM and ASM, in absolute numbers more children received prescriptions for antibiotics (42.34%, 95% CI 38.81% to 45.91%) and antiasthmatics (28.40%, 95% CI 16.07% to 42.649%) than for CVM (0.18%, 95% CI 0.12% to 0.25%) and ASM (0.16%, 95% CI 0.13% to 0.20%) in the first year of life.Conclusion Preterm children had a higher risk of being prescribed/dispensed CVM, ASM and antiasthmatics up to age 10. 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spelling v2 61953 2022-11-19 Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions 24ce9db29b4bde1af4e83b388aae0ea1 0000-0002-5691-2987 Sue Jordan Sue Jordan true false 9fcb224c6bd804a4d41a2a8570a71185 Ieuan Scanlon Ieuan Scanlon true false 2022-11-19 HNU Objectives Preterm children are exposed to many medications in neonatal intensive care units, but little is known about the effect of prematurity on medication use throughout infancy and childhood. We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthmatic medication and antibiotics issued/dispensed in the first 10 years of life for very and moderately preterm children compared with term.Design Population-based data linkage cohort study linking information from birth records to prescription records.Setting Six registries from five countries in the EUROlinkCAT study.Participants The study population included 1 722 912 children, of whom 10 820 (0.6%) were very preterm (<32 weeks gestational age (GA)), 92 814 (5.4%) were moderately preterm (32–36 weeks GA), 1 606 643 (93.3%) were born at term (≥37 weeks GA) and 0.7% had missing GA. Children with major or minor congenital anomalies were excluded (including patent ductus arteriosus).Main outcome measures Relative risk (RR) of receiving a prescription for CVM, ASM, antiasthmatic and antibiotics.Results Very preterm children had a higher RR of receiving a prescription for CVM and ASM than preterm children. For all preterm children, the RR of having a CVM prescription was 3.58 (95% CI 2.06 to 6.23); 2.06 (95% CI 1.73 to 2.41) for ASM; 1.13 (95% CI 0.99 to 1.29) for antiasthmatics and 0.96 (95% CI 0.93 to 0.99) for antibiotics in the first year of life. Increased prescription of CVM, ASM and antiasthmatics persisted for all 10 years of follow-up. Although the RR was highest for CVM and ASM, in absolute numbers more children received prescriptions for antibiotics (42.34%, 95% CI 38.81% to 45.91%) and antiasthmatics (28.40%, 95% CI 16.07% to 42.649%) than for CVM (0.18%, 95% CI 0.12% to 0.25%) and ASM (0.16%, 95% CI 0.13% to 0.20%) in the first year of life.Conclusion Preterm children had a higher risk of being prescribed/dispensed CVM, ASM and antiasthmatics up to age 10. This study highlights a need for further research into morbidity beyond age 10. Journal Article BMJ Open 12 10 e061746 BMJ 2044-6055 2044-6055 17 10 2022 2022-10-17 10.1136/bmjopen-2022-061746 COLLEGE NANME Nursing COLLEGE CODE HNU Swansea University This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 733001. 2023-09-13T16:00:56.8627127 2022-11-19T22:51:44.2997397 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Mads Damkjaer 0000-0001-7410-8573 1 Maria Loane 2 Stine Kjær Urhøj 3 Elisa Ballardini 4 Clara Cavero- Carbonell 0000-0002-4858-6456 5 Alessio Coi 6 Laura García-Villodre 7 Joanne Emma Given 0000-0003-4921-1944 8 Mika Gissler 9 Anna Heino 10 Sue Jordan 0000-0002-5691-2987 11 Amanda Neville 12 Anna Pierini 13 Joachim Tan 14 Ieuan Scanlon 15 Ester Garne 0000-0003-0430-2594 16 Joan K Morris 0000-0002-7164-612x 17 61953__26033__33c95eea5f87427bb883f6a6dcd63ccc.pdf 61953.pdf 2022-12-08T10:03:40.8381671 Output 994396 application/pdf Version of Record true This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license true eng http://creativecommons.org/licenses/by-nc/4.0/
title Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
spellingShingle Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
Sue Jordan
Ieuan Scanlon
title_short Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
title_full Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
title_fullStr Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
title_full_unstemmed Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
title_sort Preterm birth and prescriptions for cardiovascular, antiseizure, antibiotics and antiasthmatic medication in children up to 10 years of age: a population-based data linkage cohort study across six European regions
author_id_str_mv 24ce9db29b4bde1af4e83b388aae0ea1
9fcb224c6bd804a4d41a2a8570a71185
author_id_fullname_str_mv 24ce9db29b4bde1af4e83b388aae0ea1_***_Sue Jordan
9fcb224c6bd804a4d41a2a8570a71185_***_Ieuan Scanlon
author Sue Jordan
Ieuan Scanlon
author2 Mads Damkjaer
Maria Loane
Stine Kjær Urhøj
Elisa Ballardini
Clara Cavero- Carbonell
Alessio Coi
Laura García-Villodre
Joanne Emma Given
Mika Gissler
Anna Heino
Sue Jordan
Amanda Neville
Anna Pierini
Joachim Tan
Ieuan Scanlon
Ester Garne
Joan K Morris
format Journal article
container_title BMJ Open
container_volume 12
container_issue 10
container_start_page e061746
publishDate 2022
institution Swansea University
issn 2044-6055
2044-6055
doi_str_mv 10.1136/bmjopen-2022-061746
publisher BMJ
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
document_store_str 1
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description Objectives Preterm children are exposed to many medications in neonatal intensive care units, but little is known about the effect of prematurity on medication use throughout infancy and childhood. We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthmatic medication and antibiotics issued/dispensed in the first 10 years of life for very and moderately preterm children compared with term.Design Population-based data linkage cohort study linking information from birth records to prescription records.Setting Six registries from five countries in the EUROlinkCAT study.Participants The study population included 1 722 912 children, of whom 10 820 (0.6%) were very preterm (<32 weeks gestational age (GA)), 92 814 (5.4%) were moderately preterm (32–36 weeks GA), 1 606 643 (93.3%) were born at term (≥37 weeks GA) and 0.7% had missing GA. Children with major or minor congenital anomalies were excluded (including patent ductus arteriosus).Main outcome measures Relative risk (RR) of receiving a prescription for CVM, ASM, antiasthmatic and antibiotics.Results Very preterm children had a higher RR of receiving a prescription for CVM and ASM than preterm children. For all preterm children, the RR of having a CVM prescription was 3.58 (95% CI 2.06 to 6.23); 2.06 (95% CI 1.73 to 2.41) for ASM; 1.13 (95% CI 0.99 to 1.29) for antiasthmatics and 0.96 (95% CI 0.93 to 0.99) for antibiotics in the first year of life. Increased prescription of CVM, ASM and antiasthmatics persisted for all 10 years of follow-up. Although the RR was highest for CVM and ASM, in absolute numbers more children received prescriptions for antibiotics (42.34%, 95% CI 38.81% to 45.91%) and antiasthmatics (28.40%, 95% CI 16.07% to 42.649%) than for CVM (0.18%, 95% CI 0.12% to 0.25%) and ASM (0.16%, 95% CI 0.13% to 0.20%) in the first year of life.Conclusion Preterm children had a higher risk of being prescribed/dispensed CVM, ASM and antiasthmatics up to age 10. This study highlights a need for further research into morbidity beyond age 10.
published_date 2022-10-17T16:00:59Z
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