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Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories

Patrick B. Hamilton Orcid Logo, Alice Baynes Orcid Logo, Elizabeth Nicol, Graham Harris, Tamsyn Uren Webster Orcid Logo, Nicola Beresford, Marta Straszkiewicz, Susan Jobling, Charles R. Tyler

Aquatic Toxicology, Volume: 249, Start page: 106229

Swansea University Author: Tamsyn Uren Webster Orcid Logo

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DOI (Published version): 10.1016/j.aquatox.2022.106229

Abstract

Experimental exposures aimed at assessing the risks posed by estrogens in waste-water treatment work (WwTW) effluents to fish populations have rarely considered whether populations differ in their sensitivity to estrogenic compounds. This is despite evidence that selection at genes involved in the e...

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Published in: Aquatic Toxicology
ISSN: 0166-445X
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa60309
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spelling 2022-07-15T13:14:23.9268991 v2 60309 2022-06-23 Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories 3ea91c154926c86f89ea6a761122ecf6 0000-0002-0072-9745 Tamsyn Uren Webster Tamsyn Uren Webster true false 2022-06-23 SBI Experimental exposures aimed at assessing the risks posed by estrogens in waste-water treatment work (WwTW) effluents to fish populations have rarely considered whether populations differ in their sensitivity to estrogenic compounds. This is despite evidence that selection at genes involved in the estrogen response has occurred in wild populations, and evidence that genotype can influence estrogen-response. In this study we compare the effects of a two-year exposure to a low measured concentration (1.3 ng/L) of ethinylestradiol (EE2) on the sexual development of roach (Rutilus rutilus) whose parental generation was sampled from two river stretches heavily contaminated with WwTW effluent and from two without any known WwTW effluent contamination. Exposure to EE2 significantly reduced the proportion of genetic males and induced a range of feminized phenotypes in males. Significantly, exposure also increased the proportion of genetic females with vitellogenic oocytes from 51 to 96%, raising the possibility that estrogen pollution could impact populations of annually spawning fish species through advancing female reproduction by at least a year. However, there was no evidence that river origin affected sensitivity to estrogens in either sex. Thus, we conclude that chronic exposure to low level EE2 has reproductive health outcomes for both male and female roach, but we find no evidence that the nature or magnitude of the response is affected by the population origin. Journal Article Aquatic Toxicology 249 106229 Elsevier BV 0166-445X Ecotoxicology, Endocrine disruption, Pollution, Estrogen 1 8 2022 2022-08-01 10.1016/j.aquatox.2022.106229 COLLEGE NANME Biosciences COLLEGE CODE SBI Swansea University The UK Natural Environmental Research Council (NERC; NE/K004263/1) 2022-07-15T13:14:23.9268991 2022-06-23T08:41:57.9879671 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Patrick B. Hamilton 0000-0001-9549-2033 1 Alice Baynes 0000-0002-6337-5956 2 Elizabeth Nicol 3 Graham Harris 4 Tamsyn Uren Webster 0000-0002-0072-9745 5 Nicola Beresford 6 Marta Straszkiewicz 7 Susan Jobling 8 Charles R. Tyler 9 60309__24388__7ca03a924fc045148d5b1ef9a6bcdd66.pdf 60309.pdf 2022-06-24T10:54:47.6725737 Output 12074778 application/pdf Version of Record true © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license true eng https://creativecommons.org/licenses/by/4.0/
title Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
spellingShingle Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
Tamsyn Uren Webster
title_short Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
title_full Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
title_fullStr Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
title_full_unstemmed Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
title_sort Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories
author_id_str_mv 3ea91c154926c86f89ea6a761122ecf6
author_id_fullname_str_mv 3ea91c154926c86f89ea6a761122ecf6_***_Tamsyn Uren Webster
author Tamsyn Uren Webster
author2 Patrick B. Hamilton
Alice Baynes
Elizabeth Nicol
Graham Harris
Tamsyn Uren Webster
Nicola Beresford
Marta Straszkiewicz
Susan Jobling
Charles R. Tyler
format Journal article
container_title Aquatic Toxicology
container_volume 249
container_start_page 106229
publishDate 2022
institution Swansea University
issn 0166-445X
doi_str_mv 10.1016/j.aquatox.2022.106229
publisher Elsevier BV
college_str Faculty of Science and Engineering
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hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
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description Experimental exposures aimed at assessing the risks posed by estrogens in waste-water treatment work (WwTW) effluents to fish populations have rarely considered whether populations differ in their sensitivity to estrogenic compounds. This is despite evidence that selection at genes involved in the estrogen response has occurred in wild populations, and evidence that genotype can influence estrogen-response. In this study we compare the effects of a two-year exposure to a low measured concentration (1.3 ng/L) of ethinylestradiol (EE2) on the sexual development of roach (Rutilus rutilus) whose parental generation was sampled from two river stretches heavily contaminated with WwTW effluent and from two without any known WwTW effluent contamination. Exposure to EE2 significantly reduced the proportion of genetic males and induced a range of feminized phenotypes in males. Significantly, exposure also increased the proportion of genetic females with vitellogenic oocytes from 51 to 96%, raising the possibility that estrogen pollution could impact populations of annually spawning fish species through advancing female reproduction by at least a year. However, there was no evidence that river origin affected sensitivity to estrogens in either sex. Thus, we conclude that chronic exposure to low level EE2 has reproductive health outcomes for both male and female roach, but we find no evidence that the nature or magnitude of the response is affected by the population origin.
published_date 2022-08-01T04:18:19Z
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