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United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol

Lucy Teece Orcid Logo, Laura J Gray Orcid Logo, Carl Melbourne Orcid Logo, Chris Orton Orcid Logo, David Ford Orcid Logo, Christopher A Martin Orcid Logo, David McAllister, Kamlesh Khunti Orcid Logo, Martin Tobin Orcid Logo, Catherine John Orcid Logo, Keith R Abrams Orcid Logo, Manish Pareek Orcid Logo

BMJ Open, Volume: 11, Issue: 6, Start page: e046392

Swansea University Authors: Chris Orton Orcid Logo, David Ford Orcid Logo

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Abstract

Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in peo...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60383
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Abstract: Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in people working in healthcare settings is insufficient to inform plans to address health inequalities.Methods and analysis This study combines anonymised human resource databases with professional registration and National Health Service data sets to assess associations between ethnicity and COVID-19 diagnosis, hospitalisation and death in healthcare workers in the UK. Adverse COVID-19 outcomes will be assessed between 1 February 2020 (date following first confirmed COVID-19 case in UK) and study end date (31 January 2021), allowing 1-year of follow-up. Planned analyses include multivariable Poisson, logistic and flexible parametric time-to-event regression within each country, adjusting for core predictors, followed by meta-analysis of country-specific results to produce combined effect estimates for the UK. Mediation analysis methods will be explored to examine the direct, indirect and mediated interactive effects between ethnicity, occupational group and COVID-19 outcomes.Ethics and dissemination Ethical approval for the UK-REACH programme has been obtained via the expedited HRA COVID-19 processes (REC ref: 20/HRA/4718, IRAS ID: 288316). Research information will be anonymised via the Secure Anonymised Information Linkage Databank before release to researchers. Study results will be submitted for publication in an open access peer-reviewed journal and made available on our dedicated website (https://uk-reach.org/).Trial registration number ISRCTN11811602.
Keywords: COVID-19, healthcare, public health protocol
College: Faculty of Medicine, Health and Life Sciences
Funders: e MRC-UK Research and Innovation (MR/V027549/1) and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. Core funding was also provided by NIHR Biomedical Research Centres. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service (NHS), the MRC, the NIHR or the Department of Health and Social Care. This work is carried out with the support of BREATHE—The Health Data Research Hub for Respiratory Health (MC_PC_19004) in partnership with SAIL Databank through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK.
Issue: 6
Start Page: e046392