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Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
Engy A. Abdel-Rahman,
Salma Hosseiny,
Abdullah Aaliya 
,
Mohamed Adel,
Basma Yasseen ,
Abdelrahman Al-Okda ,
Yasmine Radwan,
Saber H. Saber ,
Nada Elkholy ,
Eslam Elhanafy ,
Emily E. Walker,
Juan P. Zuniga-Hertz,
Hemal H. Patel,
Helen Griffiths,
Sameh S. Ali
,
Mohamed Adel,
Basma Yasseen ,
Abdelrahman Al-Okda ,
Yasmine Radwan,
Saber H. Saber ,
Nada Elkholy ,
Eslam Elhanafy ,
Emily E. Walker,
Juan P. Zuniga-Hertz,
Hemal H. Patel,
Helen Griffiths,
Sameh S. Ali
Journal of Advanced Research, Volume: 31, Pages: 35 - 47
Swansea University Author: Helen Griffiths
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DOI (Published version): 10.1016/j.jare.2021.01.006
Abstract
Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeostasis dictate vulnerability to cardiovascular events.
| Published in: | Journal of Advanced Research |
|---|---|
| ISSN: | 2090-1232 |
| Published: |
Elsevier BV
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa60385 |
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| Abstract: |
Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeostasis dictate vulnerability to cardiovascular events. |
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| Item Description: |
Appendix A. Supplementary material via https://doi.org/10.1016/j.jare.2021.01.006 |
| Keywords: |
Heart, Mitochondria function, Calcium dynamics, Hydrogen peroxide, Diurnal, Clock genes |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This work was supported by a National Research Grant no. 6364 by
the Science and Technology Development Fund, Egypt, awarded to
SSA. SSA and EAA would like to acknowledge the support provided
by Horizon 2020, COST Action CA15203 ‘MitoEAGLE’. This work
was supported by grants from the National Institutes of Health (NIH) (HL091071, to H. H. Patel), and the Veterans Affairs (BX001963, to H. H. Patel). |
| Start Page: |
35 |
| End Page: |
47 |