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Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria

Engy A. Abdel-Rahman, Salma Hosseiny, Abdullah Aaliya Orcid Logo, Mohamed Adel, Basma Yasseen Orcid Logo, Abdelrahman Al-Okda Orcid Logo, Yasmine Radwan, Saber H. Saber Orcid Logo, Nada Elkholy Orcid Logo, Eslam Elhanafy Orcid Logo, Emily E. Walker, Juan P. Zuniga-Hertz, Hemal H. Patel, Helen Griffiths, Sameh S. Ali

Journal of Advanced Research, Volume: 31, Pages: 35 - 47

Swansea University Author: Helen Griffiths

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Abstract

Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeostasis dictate vulnerability to cardiovascular events.

Published in: Journal of Advanced Research
ISSN: 2090-1232
Published: Elsevier BV 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa60385
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spelling 2022-08-11T12:06:11.4040383 v2 60385 2022-07-05 Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria 0366ea9a689b222146b7d63c6baf8427 Helen Griffiths Helen Griffiths true false 2022-07-05 SMT Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeostasis dictate vulnerability to cardiovascular events. Journal Article Journal of Advanced Research 31 35 47 Elsevier BV 2090-1232 Heart, Mitochondria function, Calcium dynamics, Hydrogen peroxide, Diurnal, Clock genes 1 7 2021 2021-07-01 10.1016/j.jare.2021.01.006 Appendix A. Supplementary material via https://doi.org/10.1016/j.jare.2021.01.006 COLLEGE NANME Senior Leadership Team COLLEGE CODE SMT Swansea University This work was supported by a National Research Grant no. 6364 by the Science and Technology Development Fund, Egypt, awarded to SSA. SSA and EAA would like to acknowledge the support provided by Horizon 2020, COST Action CA15203 ‘MitoEAGLE’. This work was supported by grants from the National Institutes of Health (NIH) (HL091071, to H. H. Patel), and the Veterans Affairs (BX001963, to H. H. Patel). 2022-08-11T12:06:11.4040383 2022-07-05T13:43:04.6658957 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Engy A. Abdel-Rahman 1 Salma Hosseiny 2 Abdullah Aaliya 0000-0001-9165-842x 3 Mohamed Adel 4 Basma Yasseen 0000-0003-4187-0523 5 Abdelrahman Al-Okda 0000-0002-0352-7292 6 Yasmine Radwan 7 Saber H. Saber 0000-0003-1296-2023 8 Nada Elkholy 0000-0001-9665-1171 9 Eslam Elhanafy 0000-0002-0125-1958 10 Emily E. Walker 11 Juan P. Zuniga-Hertz 12 Hemal H. Patel 13 Helen Griffiths 14 Sameh S. Ali 15 60385__24453__10beb6a5c8274f2bb1721a1230f29730.pdf 60383.VOR.pdf 2022-07-05T14:58:51.7406095 Output 2086008 application/pdf Version of Record true This is an open access article under a Creative Commons CC BY-NC-ND license . true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
spellingShingle Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
Helen Griffiths
title_short Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
title_full Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
title_fullStr Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
title_full_unstemmed Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
title_sort Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
author_id_str_mv 0366ea9a689b222146b7d63c6baf8427
author_id_fullname_str_mv 0366ea9a689b222146b7d63c6baf8427_***_Helen Griffiths
author Helen Griffiths
author2 Engy A. Abdel-Rahman
Salma Hosseiny
Abdullah Aaliya
Mohamed Adel
Basma Yasseen
Abdelrahman Al-Okda
Yasmine Radwan
Saber H. Saber
Nada Elkholy
Eslam Elhanafy
Emily E. Walker
Juan P. Zuniga-Hertz
Hemal H. Patel
Helen Griffiths
Sameh S. Ali
format Journal article
container_title Journal of Advanced Research
container_volume 31
container_start_page 35
publishDate 2021
institution Swansea University
issn 2090-1232
doi_str_mv 10.1016/j.jare.2021.01.006
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeostasis dictate vulnerability to cardiovascular events.
published_date 2021-07-01T04:18:27Z
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