No Cover Image

Journal article 639 views

Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity

April Rees Orcid Logo, Oliver Richards Orcid Logo, Megan Chambers, Benjamin Jenkins, James Cronin Orcid Logo, Cathy Thornton Orcid Logo

Clinical and Experimental Immunology, Volume: 208, Issue: 2, Pages: 132 - 146

Swansea University Authors: April Rees Orcid Logo, Oliver Richards Orcid Logo, Megan Chambers, Benjamin Jenkins, James Cronin Orcid Logo, Cathy Thornton Orcid Logo

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1093/cei/uxac003

Abstract

Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunometabolism is a burgeoning field with the underlying...

Full description

Published in: Clinical and Experimental Immunology
ISSN: 0009-9104 1365-2249
Published: Oxford University Press (OUP) 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60422
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2022-07-08T14:56:00Z
last_indexed 2023-01-19T04:13:26Z
id cronfa60422
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2023-01-18T16:19:39.5206154</datestamp><bib-version>v2</bib-version><id>60422</id><entry>2022-07-08</entry><title>Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity</title><swanseaauthors><author><sid>ae088f7f8609d2b2ea4666f9b52b3c15</sid><ORCID>0000-0002-4408-634X</ORCID><firstname>April</firstname><surname>Rees</surname><name>April Rees</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>93c672d7c4bf8ebe19916d432f0ec7bb</sid><ORCID>0000-0002-5824-2745</ORCID><firstname>Oliver</firstname><surname>Richards</surname><name>Oliver Richards</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>7df677285443d1a8c1b5aab4474fa4b4</sid><firstname>Megan</firstname><surname>Chambers</surname><name>Megan Chambers</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>90f7cfd66781feba615436189178a528</sid><firstname>Benjamin</firstname><surname>Jenkins</surname><name>Benjamin Jenkins</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>9cfd17551c0d1f7438895121e4fbb6e8</sid><ORCID>0000-0002-0590-9462</ORCID><firstname>James</firstname><surname>Cronin</surname><name>James Cronin</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>c71a7a4be7361094d046d312202bce0c</sid><ORCID>0000-0002-5153-573X</ORCID><firstname>Cathy</firstname><surname>Thornton</surname><name>Cathy Thornton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-07-08</date><deptcode>BMS</deptcode><abstract>Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunometabolism is a burgeoning field with the underlying principle being that cellular metabolism underpins immune cell function. With whole body changes to the metabolism of carbohydrates, protein and lipids well recognised to occur in pregnancy and our growing understanding of immunometabolism as a determinant of immunoinflammatory effector responses, it would seem reasonable to expect immune plasticity during pregnancy to be linked to changes in the availability and handling of multiple nutrient energy sources by immune cells. While studies of immunometabolism in pregnancy are only just beginning, the recognised bi-directional interaction between metabolism and immune function in the metabolic disorder obesity might provide some of the earliest insights into the role of immunometabolism in immune plasticity in pregnancy. Characterised by chronic low-grade inflammation including in pregnant women, obesity is associated with numerous adverse outcomes during pregnancy and beyond for both mother and child. Concurrent changes in metabolism and immunoinflammation are consistently described but any causative link is not well established. Here we provide an overview of the metabolic and immunological changes that occur in pregnancy and how these might contribute to healthy versus adverse pregnancy outcomes with special consideration of possible interactions with obesity.</abstract><type>Journal Article</type><journal>Clinical and Experimental Immunology</journal><volume>208</volume><journalNumber>2</journalNumber><paginationStart>132</paginationStart><paginationEnd>146</paginationEnd><publisher>Oxford University Press (OUP)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0009-9104</issnPrint><issnElectronic>1365-2249</issnElectronic><keywords>obesity, pregnancy, immunometabolism, plasticity</keywords><publishedDay>11</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-06-11</publishedDate><doi>10.1093/cei/uxac003</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>Natural Environment Research Council; Medical Research Council; Diabetes UK</funders><projectreference/><lastEdited>2023-01-18T16:19:39.5206154</lastEdited><Created>2022-07-08T15:51:42.6435085</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>April</firstname><surname>Rees</surname><orcid>0000-0002-4408-634X</orcid><order>1</order></author><author><firstname>Oliver</firstname><surname>Richards</surname><orcid>0000-0002-5824-2745</orcid><order>2</order></author><author><firstname>Megan</firstname><surname>Chambers</surname><order>3</order></author><author><firstname>Benjamin</firstname><surname>Jenkins</surname><order>4</order></author><author><firstname>James</firstname><surname>Cronin</surname><orcid>0000-0002-0590-9462</orcid><order>5</order></author><author><firstname>Cathy</firstname><surname>Thornton</surname><orcid>0000-0002-5153-573X</orcid><order>6</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2023-01-18T16:19:39.5206154 v2 60422 2022-07-08 Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity ae088f7f8609d2b2ea4666f9b52b3c15 0000-0002-4408-634X April Rees April Rees true false 93c672d7c4bf8ebe19916d432f0ec7bb 0000-0002-5824-2745 Oliver Richards Oliver Richards true false 7df677285443d1a8c1b5aab4474fa4b4 Megan Chambers Megan Chambers true false 90f7cfd66781feba615436189178a528 Benjamin Jenkins Benjamin Jenkins true false 9cfd17551c0d1f7438895121e4fbb6e8 0000-0002-0590-9462 James Cronin James Cronin true false c71a7a4be7361094d046d312202bce0c 0000-0002-5153-573X Cathy Thornton Cathy Thornton true false 2022-07-08 BMS Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunometabolism is a burgeoning field with the underlying principle being that cellular metabolism underpins immune cell function. With whole body changes to the metabolism of carbohydrates, protein and lipids well recognised to occur in pregnancy and our growing understanding of immunometabolism as a determinant of immunoinflammatory effector responses, it would seem reasonable to expect immune plasticity during pregnancy to be linked to changes in the availability and handling of multiple nutrient energy sources by immune cells. While studies of immunometabolism in pregnancy are only just beginning, the recognised bi-directional interaction between metabolism and immune function in the metabolic disorder obesity might provide some of the earliest insights into the role of immunometabolism in immune plasticity in pregnancy. Characterised by chronic low-grade inflammation including in pregnant women, obesity is associated with numerous adverse outcomes during pregnancy and beyond for both mother and child. Concurrent changes in metabolism and immunoinflammation are consistently described but any causative link is not well established. Here we provide an overview of the metabolic and immunological changes that occur in pregnancy and how these might contribute to healthy versus adverse pregnancy outcomes with special consideration of possible interactions with obesity. Journal Article Clinical and Experimental Immunology 208 2 132 146 Oxford University Press (OUP) 0009-9104 1365-2249 obesity, pregnancy, immunometabolism, plasticity 11 6 2022 2022-06-11 10.1093/cei/uxac003 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Natural Environment Research Council; Medical Research Council; Diabetes UK 2023-01-18T16:19:39.5206154 2022-07-08T15:51:42.6435085 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine April Rees 0000-0002-4408-634X 1 Oliver Richards 0000-0002-5824-2745 2 Megan Chambers 3 Benjamin Jenkins 4 James Cronin 0000-0002-0590-9462 5 Cathy Thornton 0000-0002-5153-573X 6
title Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
spellingShingle Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
April Rees
Oliver Richards
Megan Chambers
Benjamin Jenkins
James Cronin
Cathy Thornton
title_short Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
title_full Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
title_fullStr Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
title_full_unstemmed Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
title_sort Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity
author_id_str_mv ae088f7f8609d2b2ea4666f9b52b3c15
93c672d7c4bf8ebe19916d432f0ec7bb
7df677285443d1a8c1b5aab4474fa4b4
90f7cfd66781feba615436189178a528
9cfd17551c0d1f7438895121e4fbb6e8
c71a7a4be7361094d046d312202bce0c
author_id_fullname_str_mv ae088f7f8609d2b2ea4666f9b52b3c15_***_April Rees
93c672d7c4bf8ebe19916d432f0ec7bb_***_Oliver Richards
7df677285443d1a8c1b5aab4474fa4b4_***_Megan Chambers
90f7cfd66781feba615436189178a528_***_Benjamin Jenkins
9cfd17551c0d1f7438895121e4fbb6e8_***_James Cronin
c71a7a4be7361094d046d312202bce0c_***_Cathy Thornton
author April Rees
Oliver Richards
Megan Chambers
Benjamin Jenkins
James Cronin
Cathy Thornton
author2 April Rees
Oliver Richards
Megan Chambers
Benjamin Jenkins
James Cronin
Cathy Thornton
format Journal article
container_title Clinical and Experimental Immunology
container_volume 208
container_issue 2
container_start_page 132
publishDate 2022
institution Swansea University
issn 0009-9104
1365-2249
doi_str_mv 10.1093/cei/uxac003
publisher Oxford University Press (OUP)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunometabolism is a burgeoning field with the underlying principle being that cellular metabolism underpins immune cell function. With whole body changes to the metabolism of carbohydrates, protein and lipids well recognised to occur in pregnancy and our growing understanding of immunometabolism as a determinant of immunoinflammatory effector responses, it would seem reasonable to expect immune plasticity during pregnancy to be linked to changes in the availability and handling of multiple nutrient energy sources by immune cells. While studies of immunometabolism in pregnancy are only just beginning, the recognised bi-directional interaction between metabolism and immune function in the metabolic disorder obesity might provide some of the earliest insights into the role of immunometabolism in immune plasticity in pregnancy. Characterised by chronic low-grade inflammation including in pregnant women, obesity is associated with numerous adverse outcomes during pregnancy and beyond for both mother and child. Concurrent changes in metabolism and immunoinflammation are consistently described but any causative link is not well established. Here we provide an overview of the metabolic and immunological changes that occur in pregnancy and how these might contribute to healthy versus adverse pregnancy outcomes with special consideration of possible interactions with obesity.
published_date 2022-06-11T04:18:31Z
_version_ 1763754231759634432
score 11.03559

Similar Items