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Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications

Imen Ghzaiel Orcid Logo, Khouloud Sassi, Amira Zarrouk Orcid Logo, Shubhrima Ghosh, Irundika H K Dias Orcid Logo, Thomas Nury, Mohamed Ksila, Soukaina Essadek, Mounia Tahri Joutey Orcid Logo, Fatiha Brahmi, Wafa Mihoubi, Sandrine Rup-Jacques Orcid Logo, Mohammad Samadi, Leila Rezig Orcid Logo, Smail Meziane, Taoufik Ghrairi, Olfa Masmoudi-Kouki, Sonia Hammami, Boubker Nasser, Mohamed Hammami, Yuqin Wang Orcid Logo, William Griffiths Orcid Logo, Anne Vejux, Gérard Lizard Orcid Logo

Redox Experimental Medicine, Volume: 2022, Issue: 1, Pages: R40 - R56

Swansea University Authors: Yuqin Wang Orcid Logo, William Griffiths Orcid Logo

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DOI (Published version): 10.1530/rem-22-0005

Abstract

7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned...

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Published in: Redox Experimental Medicine
ISSN: 2755-158X
Published: Bioscientifica 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60624
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Abstract: 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of 7-ketocholesterol (diet, incidence of environmental factors, and endogenous formation (autoxidation and enzymatic synthesis)) and its inactivation mechanisms which include esterification, sulfation, oxidation, and reduction. This knowledge will make it possible to act at different levels to regulate 7-ketocholesterol level and counteract its toxicity in order to limit the incidence of diseases associated with this oxysterol. These different points as well as food and biomedical applications are addressed in this review.
College: Swansea University Medical School
Funders: This work was funded by Université de Bourgogne (Dijon, France), Université Tunis El Manar (Tunis, Tunisia), Université de Monastir (Monastir, Tunisia), and Université Hassan 1er (Settat, Morocco). This work was supported by PHC UTIQUE 2021–2022 (Dr Taoufik Ghrairi, Tunisia and Dr Gérard Lizard, France; code CMCU: 22G0809/Code Campus France: 47608VJ). Imen Ghzaiel also received financial support from ABASIM (Association Bourguignonne pour les Applications des Sciences de l’Information en Médecine ; Dijon, France).
Issue: 1
Start Page: R40
End Page: R56