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Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications
Redox Experimental Medicine, Volume: 2022, Issue: 1, Pages: R40 - R56
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7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned...
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7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of 7-ketocholesterol (diet, incidence of environmental factors, and endogenous formation (autoxidation and enzymatic synthesis)) and its inactivation mechanisms which include esterification, sulfation, oxidation, and reduction. This knowledge will make it possible to act at different levels to regulate 7-ketocholesterol level and counteract its toxicity in order to limit the incidence of diseases associated with this oxysterol. These different points as well as food and biomedical applications are addressed in this review.
Swansea University Medical School
This work was funded by Université de Bourgogne (Dijon, France), Université
Tunis El Manar (Tunis, Tunisia), Université de Monastir (Monastir, Tunisia),
and Université Hassan 1er (Settat, Morocco). This work was supported
by PHC UTIQUE 2021–2022 (Dr Taoufik Ghrairi, Tunisia and Dr Gérard
Lizard, France; code CMCU: 22G0809/Code Campus France: 47608VJ).
Imen Ghzaiel also received financial support from ABASIM (Association
Bourguignonne pour les Applications des Sciences de l’Information en
Médecine ; Dijon, France).