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Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications
Redox Experimental Medicine, Volume: 2022, Issue: 1, Pages: R40 - R56
Swansea University Authors: Yuqin Wang , William Griffiths
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DOI (Published version): 10.1530/rem-22-0005
Abstract
7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned...
Published in: | Redox Experimental Medicine |
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ISSN: | 2755-158X |
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Bioscientifica
2022
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URI: | https://cronfa.swan.ac.uk/Record/cronfa60624 |
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Tunis El Manar (Tunis, Tunisia), Université de Monastir (Monastir, Tunisia),
and Université Hassan 1er (Settat, Morocco). This work was supported
by PHC UTIQUE 2021–2022 (Dr Taoufik Ghrairi, Tunisia and Dr Gérard
Lizard, France; code CMCU: 22G0809/Code Campus France: 47608VJ).
Imen Ghzaiel also received financial support from ABASIM (Association
Bourguignonne pour les Applications des Sciences de l’Information en
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2022-08-05T14:00:10.7357915 v2 60624 2022-07-25 Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2022-07-25 BMS 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of 7-ketocholesterol (diet, incidence of environmental factors, and endogenous formation (autoxidation and enzymatic synthesis)) and its inactivation mechanisms which include esterification, sulfation, oxidation, and reduction. This knowledge will make it possible to act at different levels to regulate 7-ketocholesterol level and counteract its toxicity in order to limit the incidence of diseases associated with this oxysterol. These different points as well as food and biomedical applications are addressed in this review. Journal Article Redox Experimental Medicine 2022 1 R40 R56 Bioscientifica 2755-158X 14 7 2022 2022-07-14 10.1530/rem-22-0005 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) This work was funded by Université de Bourgogne (Dijon, France), Université Tunis El Manar (Tunis, Tunisia), Université de Monastir (Monastir, Tunisia), and Université Hassan 1er (Settat, Morocco). This work was supported by PHC UTIQUE 2021–2022 (Dr Taoufik Ghrairi, Tunisia and Dr Gérard Lizard, France; code CMCU: 22G0809/Code Campus France: 47608VJ). Imen Ghzaiel also received financial support from ABASIM (Association Bourguignonne pour les Applications des Sciences de l’Information en Médecine ; Dijon, France). 2022-08-05T14:00:10.7357915 2022-07-25T11:33:07.5290995 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Imen Ghzaiel 0000-0001-8181-9445 1 Khouloud Sassi 2 Amira Zarrouk 0000-0002-9190-5328 3 Shubhrima Ghosh 4 Irundika H K Dias 0000-0002-6620-8221 5 Thomas Nury 6 Mohamed Ksila 7 Soukaina Essadek 8 Mounia Tahri Joutey 0000-0002-5565-1869 9 Fatiha Brahmi 10 Wafa Mihoubi 11 Sandrine Rup-Jacques 0000-0002-0762-4225 12 Mohammad Samadi 13 Leila Rezig 0000-0002-6243-5742 14 Smail Meziane 15 Taoufik Ghrairi 16 Olfa Masmoudi-Kouki 17 Sonia Hammami 18 Boubker Nasser 19 Mohamed Hammami 20 Yuqin Wang 0000-0002-3063-3066 21 William Griffiths 0000-0002-4129-6616 22 Anne Vejux 23 Gérard Lizard 0000-0001-6330-0172 24 60624__24730__becab538ad804c4f9997e9108765bf1f.pdf Ghzaiel RedExMed 2022.pdf 2022-07-25T11:37:34.7965732 Output 2506790 application/pdf Version of Record true © 2022 The authors. This work is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/ |
title |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications |
spellingShingle |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications Yuqin Wang William Griffiths |
title_short |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications |
title_full |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications |
title_fullStr |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications |
title_full_unstemmed |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications |
title_sort |
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications |
author_id_str_mv |
c92729b58622f9fdf6a0e7d8f4ce5081 3316b1d1b524be1831790933eed1c26e |
author_id_fullname_str_mv |
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang 3316b1d1b524be1831790933eed1c26e_***_William Griffiths |
author |
Yuqin Wang William Griffiths |
author2 |
Imen Ghzaiel Khouloud Sassi Amira Zarrouk Shubhrima Ghosh Irundika H K Dias Thomas Nury Mohamed Ksila Soukaina Essadek Mounia Tahri Joutey Fatiha Brahmi Wafa Mihoubi Sandrine Rup-Jacques Mohammad Samadi Leila Rezig Smail Meziane Taoufik Ghrairi Olfa Masmoudi-Kouki Sonia Hammami Boubker Nasser Mohamed Hammami Yuqin Wang William Griffiths Anne Vejux Gérard Lizard |
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Redox Experimental Medicine |
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2022 |
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R40 |
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Swansea University |
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2755-158X |
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10.1530/rem-22-0005 |
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Faculty of Medicine, Health and Life Sciences |
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description |
7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of 7-ketocholesterol (diet, incidence of environmental factors, and endogenous formation (autoxidation and enzymatic synthesis)) and its inactivation mechanisms which include esterification, sulfation, oxidation, and reduction. This knowledge will make it possible to act at different levels to regulate 7-ketocholesterol level and counteract its toxicity in order to limit the incidence of diseases associated with this oxysterol. These different points as well as food and biomedical applications are addressed in this review. |
published_date |
2022-07-14T04:18:53Z |
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1763754255143927808 |
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11.01628 |