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Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications

Zia Ullah Arif, Muhammad Yasir Khalid, Reza Noroozi, Ali Sadeghianmaryan Orcid Logo, Meisam Jalalvand, Mokarram Hossain Orcid Logo

International Journal of Biological Macromolecules, Volume: 218, Pages: 930 - 968

Swansea University Author: Mokarram Hossain Orcid Logo

  • Accepted Manuscript under embargo until: 24th July 2023

Abstract

The three-dimensional printing (3DP) also known as the additive manufacturing (AM), a novel and futuristic technology that facilitates the printing of multiscale, biomimetic, intricate cytoarchitecture, function-structure hierarchy, multi-cellular tissues in the complicated micro-environment, patien...

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Published in: International Journal of Biological Macromolecules
ISSN: 0141-8130
Published: Elsevier BV 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60637
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Abstract: The three-dimensional printing (3DP) also known as the additive manufacturing (AM), a novel and futuristic technology that facilitates the printing of multiscale, biomimetic, intricate cytoarchitecture, function-structure hierarchy, multi-cellular tissues in the complicated micro-environment, patient-specific scaffolds, and medical devices. There is an increasing demand for developing 3D-printed products that can be utilized for organ transplantations due to the organ shortage. Nowadays, the 3DP has gained considerable interest in the tissue engineering (TE) field. The AM of bioactive materials particularly biopolymers permits the manufacturing of implants at specific defective sites with tunable properties and controllable chemical composition. Polylactide (PLA) and polycaprolactone (PCL) are exemplary biomaterials with excellent physicochemical properties and biocompatibility, which have drawn notable attraction in tissue regeneration. Herein, the recent advancements in the PLA and PCL biodegradable polymer-based composites as well as their reinforcement with hydrogels and bio-ceramics scaffolds manufactured through 3DP are systematically summarized and the applications of bone, cardiac, neural, vascularized and skin tissue regeneration are thoroughly elucidated. The interaction between implanted biodegradable polymers, in-vivo and in-vitro testing models for possible evaluation of degradation and biological properties are also illustrated. The final section of this review incorporates the current challenges and future opportunities in the 3DP of PCL- and PLA-based composites that will prove helpful for biomedical engineers to fulfill the demands of the clinical field.
Keywords: Polylactic acid, Polycaprolactone, 3D printing, Biodegradability, Tissue engineering, Scaffolds
College: College of Engineering
Funders: This work was not supported by any funding.
Start Page: 930
End Page: 968