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Journal article 753 views

Impact of glucose levels on advanced glycation end products in hemodialysis

Ruth Godfrey Orcid Logo

Hemodialysis International, Volume: 11, Issue: 3, Pages: 278 - 285

Swansea University Author: Ruth Godfrey Orcid Logo

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Abstract

The current obesity epidemic throughout the western world has resulted in a considerable increase in the condition Type II diabetes mellitus. Recently, the World Health Organization has predicted that the global prevalence of Type II will increase from 175 million patients in 2003 to over 350 millio...

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Published in: Hemodialysis International
ISSN: 1492-7535 1542-4758
Published: Wiley 2007
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa6121
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Abstract: The current obesity epidemic throughout the western world has resulted in a considerable increase in the condition Type II diabetes mellitus. Recently, the World Health Organization has predicted that the global prevalence of Type II will increase from 175 million patients in 2003 to over 350 million by 2030. One of the major consequences of this disorder is renal failure, which presents itself as chronic kidney disease, and can progress to end-stage renal disease. Once diagnosed, patients are generally treated using dialysis due to a shortage of kidney donors. The fundamental process of dialysis still requires improvement because the survival rate of these patients is relatively poor. This has resulted in considerable research into improvements in hemodialysis membranes, and the challenge to find more suitable marker(s) in assessing the efficacy of the dialysis process. A class of compounds highlighted as a possible accumulative toxin is advanced glycation end products or AGEs. This is an article regarding the impact of hemodialysis and hemodiafiltration on glucose and AGE levels within the body and the consequences of a chronic hyperglycemic condition. It also highlights the negative aspects of using dextrose in conventional dialysis solutions (an area that has already been identified by peritoneal dialysis clinicians as problematic). The review concludes by suggesting several possible topics of future research.
College: Swansea University Medical School
Issue: 3
Start Page: 278
End Page: 285