Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study

Nicholas, Richard; Heaven, Martin; Middleton, Rod; Chevli, Manoj; Pulikottil-Jacob, Ruth; Jones, Kerina; Ford, David

doi:10.1177/2055217320901727

Journal article 22637 views 74 downloads

Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study

Richard Nicholas, Martin Heaven, Rod Middleton

, Manoj Chevli, Ruth Pulikottil-Jacob, Kerina Jones

, David Ford

Multiple Sclerosis Journal - Experimental, Translational and Clinical, Volume: 6, Issue: 1, Start page: 205521732090172

Swansea University Authors: Richard Nicholas, Martin Heaven, Rod Middleton , Kerina Jones , David Ford

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DOI (Published version): 10.1177/2055217320901727

Abstract

ObjectivesTo investigate through survey and data linkage, healthcare resource use and costs (except drugs), including who bears the cost, of multiple sclerosis in the United Kingdom by disease severity and type.MethodsThe United Kingdom Multiple Sclerosis Register deployed a cost of illness survey,...

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Published in:	Multiple Sclerosis Journal - Experimental, Translational and Clinical
ISSN:	2055-2173 2055-2173
Published:	SAGE Publications 2020
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa61478
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first_indexed	2022-10-20T15:13:12Z
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Resource consumption was categorised as being medical or non-medical and costed by National Health Service and social services estimates for 2018.ResultsWe calculated £509,003 in non-medical costs over a year and £435,488 in medical costs generated over 3 months. People with multiple sclerosis reported self-funding 75% of non-medical costs with non-medical interventions having long-term potential benefits. Costs increased with disability as measured by patient-reported Expanded Disability Status Score and Multiple Sclerosis Impact Scale, with Multiple Sclerosis Impact Scale physical being a more powerful predictor of costs than the patient-reported Expanded Disability Status Score. Two distinct groups were identified: medical and non-medical interventions (n = 138); and medical interventions only (n = 399). The medical and non-medical group reported increased disease severity and reduced employment but incurred 80% more medical costs per person than the medical-only group.ConclusionsThe importance of disability in driving costs is illustrated with balance between medical and non-medical costs consistent with the United Kingdom health environment. People with multiple sclerosis and their families fund a considerable proportion of non-medical costs but non-medical interventions with longer term impact could affect future medical costs.</abstract><type>Journal Article</type><journal>Multiple Sclerosis Journal - Experimental, Translational and Clinical</journal><volume>6</volume><journalNumber>1</journalNumber><paginationStart>205521732090172</paginationStart><paginationEnd/><publisher>SAGE Publications</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>2055-2173</issnPrint><issnElectronic>2055-2173</issnElectronic><keywords>Resource use; medical and non-medical costing; multiple sclerosis; disability; UKMS register</keywords><publishedDay>22</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-01-22</publishedDate><doi>10.1177/2055217320901727</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2022-10-20T16:15:05.4406589</lastEdited><Created>2022-10-07T11:56:06.0181095</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Richard</firstname><surname>Nicholas</surname><order>1</order></author><author><firstname>Martin</firstname><surname>Heaven</surname><order>2</order></author><author><firstname>Rod</firstname><surname>Middleton</surname><orcid>0000-0002-2130-4420</orcid><order>3</order></author><author><firstname>Manoj</firstname><surname>Chevli</surname><order>4</order></author><author><firstname>Ruth</firstname><surname>Pulikottil-Jacob</surname><order>5</order></author><author><firstname>Kerina</firstname><surname>Jones</surname><orcid>0000-0001-8164-3718</orcid><order>6</order></author><author><firstname>David</firstname><surname>Ford</surname><orcid>0000-0001-6551-721X</orcid><order>7</order></author></authors><documents><document><filename>61478__25538__54a6f555b1164f5692786c9571da1575.pdf</filename><originalFilename>61478_VoR.pdf</originalFilename><uploaded>2022-10-20T16:13:43.8244564</uploaded><type>Output</type><contentLength>443387</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright: The Author(s), 2020. 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spelling	2022-10-20T16:15:05.4406589 v2 61478 2022-10-07 Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study b1b6e8c9f6c79bdd07143f24db58f792 Richard Nicholas Richard Nicholas true false 8cf2eadb1a9a0b58dfe45644838545d5 Martin Heaven Martin Heaven true false 005518f819ef1a2a13fdf438529bdfcd 0000-0002-2130-4420 Rod Middleton Rod Middleton true false c13b3cd0a6f8cbac2e461b54b3cdd839 0000-0001-8164-3718 Kerina Jones Kerina Jones true false 52fc0c473b0da1b7218d87f9fc68a3e6 0000-0001-6551-721X David Ford David Ford true false 2022-10-07 FGMHL ObjectivesTo investigate through survey and data linkage, healthcare resource use and costs (except drugs), including who bears the cost, of multiple sclerosis in the United Kingdom by disease severity and type.MethodsThe United Kingdom Multiple Sclerosis Register deployed a cost of illness survey, completed by people with multiple sclerosis and linked this with data within the United Kingdom Multiple Sclerosis Register and from their hospital records. Resource consumption was categorised as being medical or non-medical and costed by National Health Service and social services estimates for 2018.ResultsWe calculated £509,003 in non-medical costs over a year and £435,488 in medical costs generated over 3 months. People with multiple sclerosis reported self-funding 75% of non-medical costs with non-medical interventions having long-term potential benefits. Costs increased with disability as measured by patient-reported Expanded Disability Status Score and Multiple Sclerosis Impact Scale, with Multiple Sclerosis Impact Scale physical being a more powerful predictor of costs than the patient-reported Expanded Disability Status Score. Two distinct groups were identified: medical and non-medical interventions (n = 138); and medical interventions only (n = 399). The medical and non-medical group reported increased disease severity and reduced employment but incurred 80% more medical costs per person than the medical-only group.ConclusionsThe importance of disability in driving costs is illustrated with balance between medical and non-medical costs consistent with the United Kingdom health environment. People with multiple sclerosis and their families fund a considerable proportion of non-medical costs but non-medical interventions with longer term impact could affect future medical costs. Journal Article Multiple Sclerosis Journal - Experimental, Translational and Clinical 6 1 205521732090172 SAGE Publications 2055-2173 2055-2173 Resource use; medical and non-medical costing; multiple sclerosis; disability; UKMS register 22 1 2020 2020-01-22 10.1177/2055217320901727 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2022-10-20T16:15:05.4406589 2022-10-07T11:56:06.0181095 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Richard Nicholas 1 Martin Heaven 2 Rod Middleton 0000-0002-2130-4420 3 Manoj Chevli 4 Ruth Pulikottil-Jacob 5 Kerina Jones 0000-0001-8164-3718 6 David Ford 0000-0001-6551-721X 7 61478__25538__54a6f555b1164f5692786c9571da1575.pdf 61478_VoR.pdf 2022-10-20T16:13:43.8244564 Output 443387 application/pdf Version of Record true Copyright: The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License true eng https://creativecommons.org/licenses/by-nc/4.0/
title	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study
spellingShingle	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study Richard Nicholas Martin Heaven Rod Middleton Kerina Jones David Ford
title_short	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study
title_full	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study
title_fullStr	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study
title_full_unstemmed	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study
title_sort	Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study
author_id_str_mv	b1b6e8c9f6c79bdd07143f24db58f792 8cf2eadb1a9a0b58dfe45644838545d5 005518f819ef1a2a13fdf438529bdfcd c13b3cd0a6f8cbac2e461b54b3cdd839 52fc0c473b0da1b7218d87f9fc68a3e6
author_id_fullname_str_mv	b1b6e8c9f6c79bdd07143f24db58f792_*_Richard Nicholas 8cf2eadb1a9a0b58dfe45644838545d5__Martin Heaven 005518f819ef1a2a13fdf438529bdfcd__Rod Middleton c13b3cd0a6f8cbac2e461b54b3cdd839__Kerina Jones 52fc0c473b0da1b7218d87f9fc68a3e6_**_David Ford
author	Richard Nicholas Martin Heaven Rod Middleton Kerina Jones David Ford
author2	Richard Nicholas Martin Heaven Rod Middleton Manoj Chevli Ruth Pulikottil-Jacob Kerina Jones David Ford
format	Journal article
container_title	Multiple Sclerosis Journal - Experimental, Translational and Clinical
container_volume	6
container_issue	1
container_start_page	205521732090172
publishDate	2020
institution	Swansea University
issn	2055-2173 2055-2173
doi_str_mv	10.1177/2055217320901727
publisher	SAGE Publications
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	ObjectivesTo investigate through survey and data linkage, healthcare resource use and costs (except drugs), including who bears the cost, of multiple sclerosis in the United Kingdom by disease severity and type.MethodsThe United Kingdom Multiple Sclerosis Register deployed a cost of illness survey, completed by people with multiple sclerosis and linked this with data within the United Kingdom Multiple Sclerosis Register and from their hospital records. Resource consumption was categorised as being medical or non-medical and costed by National Health Service and social services estimates for 2018.ResultsWe calculated £509,003 in non-medical costs over a year and £435,488 in medical costs generated over 3 months. People with multiple sclerosis reported self-funding 75% of non-medical costs with non-medical interventions having long-term potential benefits. Costs increased with disability as measured by patient-reported Expanded Disability Status Score and Multiple Sclerosis Impact Scale, with Multiple Sclerosis Impact Scale physical being a more powerful predictor of costs than the patient-reported Expanded Disability Status Score. Two distinct groups were identified: medical and non-medical interventions (n = 138); and medical interventions only (n = 399). The medical and non-medical group reported increased disease severity and reduced employment but incurred 80% more medical costs per person than the medical-only group.ConclusionsThe importance of disability in driving costs is illustrated with balance between medical and non-medical costs consistent with the United Kingdom health environment. People with multiple sclerosis and their families fund a considerable proportion of non-medical costs but non-medical interventions with longer term impact could affect future medical costs.
published_date	2020-01-22T04:20:19Z
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Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study

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