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Chemical warfare between fungus-growing ants and their pathogens

Sibyl F.D. Batey, Claudio Greco Orcid Logo, Matthew I. Hutchings, Barrie Wilkinson Orcid Logo

Current Opinion in Chemical Biology, Volume: 59, Pages: 172 - 181

Swansea University Author: Claudio Greco Orcid Logo

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DOI (Published version): 10.1016/j.cbpa.2020.08.001

Abstract

Fungus-growing attine ants are under constant threat from fungal pathogens such as the specialized mycoparasite Escovopsis, which uses combined physical and chemical attack strategies to prey on the fungal gardens of the ants. In defence, some species assemble protective microbiomes on their exoskel...

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Published in: Current Opinion in Chemical Biology
ISSN: 1367-5931
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa61517
first_indexed 2022-10-20T12:18:49Z
last_indexed 2023-01-13T19:22:19Z
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spelling 2022-10-20T13:22:37.8766014 v2 61517 2022-10-10 Chemical warfare between fungus-growing ants and their pathogens cacac6459bd7cf4a241f63661006036f 0000-0003-3067-0999 Claudio Greco Claudio Greco true false 2022-10-10 BGPS Fungus-growing attine ants are under constant threat from fungal pathogens such as the specialized mycoparasite Escovopsis, which uses combined physical and chemical attack strategies to prey on the fungal gardens of the ants. In defence, some species assemble protective microbiomes on their exoskeletons that contain antimicrobial-producing Actinobacteria. Underlying this network of mutualistic and antagonistic interactions are an array of chemical signals. Escovopsis weberi produces the shearinine terpene-indole alkaloids, which affect ant behaviour, diketopiperazines to combat defensive bacteria, and other small molecules that inhibit the fungal cultivar. Pseudonocardia and Streptomyces mutualist bacteria produce depsipeptide and polyene macrolide antifungals active against Escovopsis spp. The ant nest metabolome is further complicated by competition between defensive bacteria, which produce antibacterials active against even closely related species. Journal Article Current Opinion in Chemical Biology 59 172 181 Elsevier BV 1367-5931 Fungus-growing ants; Mutualism; Antagonism; Specialized metabolites; Escovopsis; Pseudonocardia; Streptomyces; Antimicrobials 1 12 2020 2020-12-01 10.1016/j.cbpa.2020.08.001 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) via Institute Strategic Program Project BBS/E/J/00PR9791 to the John Innes Centre, BBSRC responsive mode grants BB/S009000/1 (to BW) and BB/S00811X/1 (to MIH) and Natural Environment Research Council grants NE/J01074X/1 and NE/M015033/1 (to MIH) and NE/M014657/1 (to BW). 2022-10-20T13:22:37.8766014 2022-10-10T17:24:04.5001691 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Sibyl F.D. Batey 1 Claudio Greco 0000-0003-3067-0999 2 Matthew I. Hutchings 3 Barrie Wilkinson 0000-0001-7646-7174 4 61517__25522__b0473bf3c04b476e85a26e44e7af4a60.pdf 61517_VoR.pdf 2022-10-20T13:19:27.7179348 Output 1231829 application/pdf Version of Record true © 2020 The Author(s). This is an open access article under the CC BY license true eng http://creativecommons.org/licenses/by/4.0/
title Chemical warfare between fungus-growing ants and their pathogens
spellingShingle Chemical warfare between fungus-growing ants and their pathogens
Claudio Greco
title_short Chemical warfare between fungus-growing ants and their pathogens
title_full Chemical warfare between fungus-growing ants and their pathogens
title_fullStr Chemical warfare between fungus-growing ants and their pathogens
title_full_unstemmed Chemical warfare between fungus-growing ants and their pathogens
title_sort Chemical warfare between fungus-growing ants and their pathogens
author_id_str_mv cacac6459bd7cf4a241f63661006036f
author_id_fullname_str_mv cacac6459bd7cf4a241f63661006036f_***_Claudio Greco
author Claudio Greco
author2 Sibyl F.D. Batey
Claudio Greco
Matthew I. Hutchings
Barrie Wilkinson
format Journal article
container_title Current Opinion in Chemical Biology
container_volume 59
container_start_page 172
publishDate 2020
institution Swansea University
issn 1367-5931
doi_str_mv 10.1016/j.cbpa.2020.08.001
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Fungus-growing attine ants are under constant threat from fungal pathogens such as the specialized mycoparasite Escovopsis, which uses combined physical and chemical attack strategies to prey on the fungal gardens of the ants. In defence, some species assemble protective microbiomes on their exoskeletons that contain antimicrobial-producing Actinobacteria. Underlying this network of mutualistic and antagonistic interactions are an array of chemical signals. Escovopsis weberi produces the shearinine terpene-indole alkaloids, which affect ant behaviour, diketopiperazines to combat defensive bacteria, and other small molecules that inhibit the fungal cultivar. Pseudonocardia and Streptomyces mutualist bacteria produce depsipeptide and polyene macrolide antifungals active against Escovopsis spp. The ant nest metabolome is further complicated by competition between defensive bacteria, which produce antibacterials active against even closely related species.
published_date 2020-12-01T20:28:52Z
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