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Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis

Martina Sassi, Alwena Morgan Orcid Logo, Jeffrey Davies Orcid Logo

Cells, Volume: 11, Issue: 5, Start page: 765

Swansea University Authors: Martina Sassi, Alwena Morgan Orcid Logo, Jeffrey Davies Orcid Logo

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DOI (Published version): 10.3390/cells11050765

Abstract

Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulates adult hippocampal neurogenesis while the unacylated...

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Published in: Cells
ISSN: 2073-4409
Published: MDPI AG 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa61551
first_indexed 2022-10-20T10:09:30Z
last_indexed 2023-01-13T19:22:22Z
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spelling 2022-10-20T11:11:07.3397965 v2 61551 2022-10-13 Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis 73844ea9bb96bff6f83ffeffa8f64a49 Martina Sassi Martina Sassi true false 9ea39c3d0935c897cb9fcd3ba550af71 0000-0002-3441-5357 Alwena Morgan Alwena Morgan true false 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false 2022-10-13 Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulates adult hippocampal neurogenesis while the unacylated form of ghrelin inhibits it, thus demonstrating a previously unknown function of unacyl-ghrelin in modulating hippocampal plasticity. Analysis of plasma samples from Parkinson’s disease patients with dementia demonstrated a reduced acyl-ghrelin:unacyl-ghrelin ratio compared to both healthy controls and cognitively intact Parkinson’s disease patients. These data, from mouse and human studies, suggest that restoring acyl-ghrelin signalling may promote the activation of pathways to support memory function. In this short review, we discuss the evidence for ghrelin’s role in regulating adult hippocampal neurogenesis and the enzymes involved in ghrelin acylation and de-acylation as targets to treat mood-related disorders and dementia. Journal Article Cells 11 5 765 MDPI AG 2073-4409 acyl-ghrelin; unacyl-ghrelin; APT1; BChE; neurodegeneration; dementia; neurogenesis 22 2 2022 2022-02-22 10.3390/cells11050765 COLLEGE NANME COLLEGE CODE Swansea University This research was supported by funding from BRACE Dementia Research and The Galen and Hilary Weston Foundation. 2022-10-20T11:11:07.3397965 2022-10-13T16:05:32.4569094 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Martina Sassi 1 Alwena Morgan 0000-0002-3441-5357 2 Jeffrey Davies 0000-0002-4234-0033 3 61551__25515__19072f14b42745bf86fb2607f4eab71f.pdf 61551_VoR.pdf 2022-10-20T11:09:50.1461686 Output 308454 application/pdf Version of Record true © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license true eng https://creativecommons.org/licenses/by/4.0/
title Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
spellingShingle Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
Martina Sassi
Alwena Morgan
Jeffrey Davies
title_short Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
title_full Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
title_fullStr Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
title_full_unstemmed Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
title_sort Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
author_id_str_mv 73844ea9bb96bff6f83ffeffa8f64a49
9ea39c3d0935c897cb9fcd3ba550af71
2cb3d1d96a7870a84d2f758e865172e6
author_id_fullname_str_mv 73844ea9bb96bff6f83ffeffa8f64a49_***_Martina Sassi
9ea39c3d0935c897cb9fcd3ba550af71_***_Alwena Morgan
2cb3d1d96a7870a84d2f758e865172e6_***_Jeffrey Davies
author Martina Sassi
Alwena Morgan
Jeffrey Davies
author2 Martina Sassi
Alwena Morgan
Jeffrey Davies
format Journal article
container_title Cells
container_volume 11
container_issue 5
container_start_page 765
publishDate 2022
institution Swansea University
issn 2073-4409
doi_str_mv 10.3390/cells11050765
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulates adult hippocampal neurogenesis while the unacylated form of ghrelin inhibits it, thus demonstrating a previously unknown function of unacyl-ghrelin in modulating hippocampal plasticity. Analysis of plasma samples from Parkinson’s disease patients with dementia demonstrated a reduced acyl-ghrelin:unacyl-ghrelin ratio compared to both healthy controls and cognitively intact Parkinson’s disease patients. These data, from mouse and human studies, suggest that restoring acyl-ghrelin signalling may promote the activation of pathways to support memory function. In this short review, we discuss the evidence for ghrelin’s role in regulating adult hippocampal neurogenesis and the enzymes involved in ghrelin acylation and de-acylation as targets to treat mood-related disorders and dementia.
published_date 2022-02-22T14:17:14Z
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