Journal article 524 views 53 downloads
Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
,
Fangfang Lu,
Shayda Maleki-Toyserkani,
Ruth Jones,
Valentina M T Bart,
Ellie Pring,
Aljawharah Alrubayyi,
Felix C Richter ,
D Oliver Scourfield,
Jan Rehwinkel,
Patrícia R S Rodrigues,
Luke Davies ,
Ester Gea-Mallorquí ,
(The Oxford-Cardiff COVID19 Literature Consortium)
Oxford Open Immunology, Volume: 1, Issue: 1
Swansea University Author:
Luke Davies
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Copyright: The Author(s) 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
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DOI (Published version): 10.1093/oxfimm/iqaa004
Abstract
The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and an...
| Published in: | Oxford Open Immunology |
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| ISSN: | 2633-6960 |
| Published: |
Oxford University Press (OUP)
2020
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa61691 |
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| Abstract: |
The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II. |
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| Keywords: |
SARS-CoV-2, COVID-19, viral entry, viral evasion, host response, interferon |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
1 |