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Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion

Clarissa Coveney, Michel Tellier Orcid Logo, Fangfang Lu, Shayda Maleki-Toyserkani, Ruth Jones, Valentina M T Bart, Ellie Pring, Aljawharah Alrubayyi, Felix C Richter Orcid Logo, D Oliver Scourfield, Jan Rehwinkel, Patrícia R S Rodrigues, Luke Davies Orcid Logo, Ester Gea-Mallorquí Orcid Logo, (The Oxford-Cardiff COVID19 Literature Consortium)

Oxford Open Immunology, Volume: 1, Issue: 1

Swansea University Author: Luke Davies Orcid Logo

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DOI (Published version): 10.1093/oxfimm/iqaa004

Abstract

The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and an...

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Published in: Oxford Open Immunology
ISSN: 2633-6960
Published: Oxford University Press (OUP) 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa61691
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spelling 2022-11-07T15:15:08.5182188 v2 61691 2022-10-31 Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion ff080296775381560053d5e3a6e81745 0000-0001-7767-4060 Luke Davies Luke Davies true false 2022-10-31 BMS The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II. Journal Article Oxford Open Immunology 1 1 Oxford University Press (OUP) 2633-6960 SARS-CoV-2, COVID-19, viral entry, viral evasion, host response, interferon 8 12 2020 2020-12-08 10.1093/oxfimm/iqaa004 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2022-11-07T15:15:08.5182188 2022-10-31T12:35:07.5135152 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Clarissa Coveney 1 Michel Tellier 0000-0002-4130-9050 2 Fangfang Lu 3 Shayda Maleki-Toyserkani 4 Ruth Jones 5 Valentina M T Bart 6 Ellie Pring 7 Aljawharah Alrubayyi 8 Felix C Richter 0000-0002-3415-3449 9 D Oliver Scourfield 10 Jan Rehwinkel 11 Patrícia R S Rodrigues 12 Luke Davies 0000-0001-7767-4060 13 Ester Gea-Mallorquí 0000-0002-6915-074x 14 (The Oxford-Cardiff COVID19 Literature Consortium) 15 61691__25678__d068bbdc4b9b480ea277fb8902fc00b7.pdf 61691.pdf 2022-11-07T15:13:52.5580764 Output 933727 application/pdf Version of Record true Copyright: The Author(s) 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
spellingShingle Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
Luke Davies
title_short Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
title_full Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
title_fullStr Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
title_full_unstemmed Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
title_sort Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion
author_id_str_mv ff080296775381560053d5e3a6e81745
author_id_fullname_str_mv ff080296775381560053d5e3a6e81745_***_Luke Davies
author Luke Davies
author2 Clarissa Coveney
Michel Tellier
Fangfang Lu
Shayda Maleki-Toyserkani
Ruth Jones
Valentina M T Bart
Ellie Pring
Aljawharah Alrubayyi
Felix C Richter
D Oliver Scourfield
Jan Rehwinkel
Patrícia R S Rodrigues
Luke Davies
Ester Gea-Mallorquí
(The Oxford-Cardiff COVID19 Literature Consortium)
format Journal article
container_title Oxford Open Immunology
container_volume 1
container_issue 1
publishDate 2020
institution Swansea University
issn 2633-6960
doi_str_mv 10.1093/oxfimm/iqaa004
publisher Oxford University Press (OUP)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II.
published_date 2020-12-08T04:20:42Z
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