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Tissue‐resident macrophages: then and now

Luke Davies Orcid Logo, Philip R. Taylor

Immunology, Volume: 144, Issue: 4, Pages: 541 - 548

Swansea University Author: Luke Davies Orcid Logo

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DOI (Published version): 10.1111/imm.12451

Abstract

Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-infl...

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Published in: Immunology
ISSN: 0019-2805 1365-2567
Published: Wiley 2015
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa61706
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Abstract: Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-inflammatory or anti-inflammatory functions. Tissue-resident macrophages were regarded as differentiated monocytes, which seed the tissues to perform immune sentinel and homeostatic functions. However, tissue-resident macrophages are not a homogeneous population, but are in fact a grouping of cells with similar functions and phenotypes. In the last decade, it has been revealed that many of these cells are not terminally differentiated and, in most cases, are not derived from haematopoiesis in the adult. Recent research has highlighted that tissue-resident macrophages cannot be grouped into simple polarized categories, especially in vivo, when they are exposed to complex signalling events. It has now been demonstrated that the tissue environment itself is a major controller of macrophage phenotype, and can influence the expression of many genes regardless of origin. This is consistent with the concept that cells within different tissues have diverse responses in inflammation. There is still a mountain to climb in the field, as it evolves to encompass not only tissue-resident macrophage diversity, but also categorization of specific tissue environments and the plasticity of macrophages themselves. This knowledge provides a new perspective on therapeutic strategies, as macrophage subsets can potentially be manipulated to control the inflammatory environment in a tissue-specific manner.
Keywords: environmental programming; Gata6; tissue-resident macrophages
College: Faculty of Medicine, Health and Life Sciences
Funders: Medical Research Council; Wellcome Trust Institutional Strategic Support Fund; LEI; National Cancer Institute; National Institutes of Health; Intramural Research Program USA; Medical Research Council UK
Issue: 4
Start Page: 541
End Page: 548