Tissue‐resident macrophages: then and now

Davies, Luke; Taylor, Philip R.

doi:10.1111/imm.12451

Journal article 387 views 52 downloads

Tissue‐resident macrophages: then and now

Luke Davies

, Philip R. Taylor

Immunology, Volume: 144, Issue: 4, Pages: 541 - 548

Swansea University Author: Luke Davies

PDF | Version of Record

Copyright: 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution License
Download (386.73KB)

Check full text

DOI (Published version): 10.1111/imm.12451

Abstract

Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-infl...

Full description

Published in:	Immunology
ISSN:	0019-2805 1365-2567
Published:	Wiley 2015
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa61706
Tags:	Add Tag No Tags, Be the first to tag this record!

first_indexed	2022-11-07T10:59:29Z
last_indexed	2023-01-13T19:22:38Z
id	cronfa61706
recordtype	SURis
fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2022-11-07T11:01:09.4711220</datestamp><bib-version>v2</bib-version><id>61706</id><entry>2022-10-31</entry><title>Tissue‐resident macrophages: then and now</title><swanseaauthors><author><sid>ff080296775381560053d5e3a6e81745</sid><ORCID>0000-0001-7767-4060</ORCID><firstname>Luke</firstname><surname>Davies</surname><name>Luke Davies</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-10-31</date><deptcode>BMS</deptcode><abstract>Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-inflammatory or anti-inflammatory functions. Tissue-resident macrophages were regarded as differentiated monocytes, which seed the tissues to perform immune sentinel and homeostatic functions. However, tissue-resident macrophages are not a homogeneous population, but are in fact a grouping of cells with similar functions and phenotypes. In the last decade, it has been revealed that many of these cells are not terminally differentiated and, in most cases, are not derived from haematopoiesis in the adult. Recent research has highlighted that tissue-resident macrophages cannot be grouped into simple polarized categories, especially in vivo, when they are exposed to complex signalling events. It has now been demonstrated that the tissue environment itself is a major controller of macrophage phenotype, and can influence the expression of many genes regardless of origin. This is consistent with the concept that cells within different tissues have diverse responses in inflammation. There is still a mountain to climb in the field, as it evolves to encompass not only tissue-resident macrophage diversity, but also categorization of specific tissue environments and the plasticity of macrophages themselves. This knowledge provides a new perspective on therapeutic strategies, as macrophage subsets can potentially be manipulated to control the inflammatory environment in a tissue-specific manner.</abstract><type>Journal Article</type><journal>Immunology</journal><volume>144</volume><journalNumber>4</journalNumber><paginationStart>541</paginationStart><paginationEnd>548</paginationEnd><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0019-2805</issnPrint><issnElectronic>1365-2567</issnElectronic><keywords>environmental programming; Gata6; tissue-resident macrophages</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2015</publishedYear><publishedDate>2015-04-01</publishedDate><doi>10.1111/imm.12451</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>Medical Research Council; Wellcome Trust Institutional Strategic Support Fund; LEI; National Cancer Institute; National Institutes of Health; Intramural Research Program USA; Medical Research Council UK</funders><projectreference/><lastEdited>2022-11-07T11:01:09.4711220</lastEdited><Created>2022-10-31T12:40:39.0439264</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Luke</firstname><surname>Davies</surname><orcid>0000-0001-7767-4060</orcid><order>1</order></author><author><firstname>Philip R.</firstname><surname>Taylor</surname><order>2</order></author></authors><documents><document><filename>61706__25663__e9046a6e7d1d44ea86a00e6796aa8857.pdf</filename><originalFilename>61706.pdf</originalFilename><uploaded>2022-11-07T11:00:04.9568561</uploaded><type>Output</type><contentLength>396014</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright: 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling	2022-11-07T11:01:09.4711220 v2 61706 2022-10-31 Tissue‐resident macrophages: then and now ff080296775381560053d5e3a6e81745 0000-0001-7767-4060 Luke Davies Luke Davies true false 2022-10-31 BMS Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-inflammatory or anti-inflammatory functions. Tissue-resident macrophages were regarded as differentiated monocytes, which seed the tissues to perform immune sentinel and homeostatic functions. However, tissue-resident macrophages are not a homogeneous population, but are in fact a grouping of cells with similar functions and phenotypes. In the last decade, it has been revealed that many of these cells are not terminally differentiated and, in most cases, are not derived from haematopoiesis in the adult. Recent research has highlighted that tissue-resident macrophages cannot be grouped into simple polarized categories, especially in vivo, when they are exposed to complex signalling events. It has now been demonstrated that the tissue environment itself is a major controller of macrophage phenotype, and can influence the expression of many genes regardless of origin. This is consistent with the concept that cells within different tissues have diverse responses in inflammation. There is still a mountain to climb in the field, as it evolves to encompass not only tissue-resident macrophage diversity, but also categorization of specific tissue environments and the plasticity of macrophages themselves. This knowledge provides a new perspective on therapeutic strategies, as macrophage subsets can potentially be manipulated to control the inflammatory environment in a tissue-specific manner. Journal Article Immunology 144 4 541 548 Wiley 0019-2805 1365-2567 environmental programming; Gata6; tissue-resident macrophages 1 4 2015 2015-04-01 10.1111/imm.12451 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Medical Research Council; Wellcome Trust Institutional Strategic Support Fund; LEI; National Cancer Institute; National Institutes of Health; Intramural Research Program USA; Medical Research Council UK 2022-11-07T11:01:09.4711220 2022-10-31T12:40:39.0439264 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Luke Davies 0000-0001-7767-4060 1 Philip R. Taylor 2 61706__25663__e9046a6e7d1d44ea86a00e6796aa8857.pdf 61706.pdf 2022-11-07T11:00:04.9568561 Output 396014 application/pdf Version of Record true Copyright: 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title	Tissue‐resident macrophages: then and now
spellingShingle	Tissue‐resident macrophages: then and now Luke Davies
title_short	Tissue‐resident macrophages: then and now
title_full	Tissue‐resident macrophages: then and now
title_fullStr	Tissue‐resident macrophages: then and now
title_full_unstemmed	Tissue‐resident macrophages: then and now
title_sort	Tissue‐resident macrophages: then and now
author_id_str_mv	ff080296775381560053d5e3a6e81745
author_id_fullname_str_mv	ff080296775381560053d5e3a6e81745_***_Luke Davies
author	Luke Davies
author2	Luke Davies Philip R. Taylor
format	Journal article
container_title	Immunology
container_volume	144
container_issue	4
container_start_page	541
publishDate	2015
institution	Swansea University
issn	0019-2805 1365-2567
doi_str_mv	10.1111/imm.12451
publisher	Wiley
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	1
active_str	0
description	Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-inflammatory or anti-inflammatory functions. Tissue-resident macrophages were regarded as differentiated monocytes, which seed the tissues to perform immune sentinel and homeostatic functions. However, tissue-resident macrophages are not a homogeneous population, but are in fact a grouping of cells with similar functions and phenotypes. In the last decade, it has been revealed that many of these cells are not terminally differentiated and, in most cases, are not derived from haematopoiesis in the adult. Recent research has highlighted that tissue-resident macrophages cannot be grouped into simple polarized categories, especially in vivo, when they are exposed to complex signalling events. It has now been demonstrated that the tissue environment itself is a major controller of macrophage phenotype, and can influence the expression of many genes regardless of origin. This is consistent with the concept that cells within different tissues have diverse responses in inflammation. There is still a mountain to climb in the field, as it evolves to encompass not only tissue-resident macrophage diversity, but also categorization of specific tissue environments and the plasticity of macrophages themselves. This knowledge provides a new perspective on therapeutic strategies, as macrophage subsets can potentially be manipulated to control the inflammatory environment in a tissue-specific manner.
published_date	2015-04-01T04:20:43Z
_version_	1763754370735800320
score	10.997956

Tissue‐resident macrophages: then and now

Similar Items