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Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study
,
Mathijs Drummen,
Lea Tischmann,
Nils Swindell,
Gareth Stratton ,
Anne Raben,
Marit Westerterp,
Tanja Adam,
Nils Joseph Swindell
Obesity, Volume: 31, Issue: 3, Pages: 744 - 756
Swansea University Authors:
Nils Swindell, Gareth Stratton , Nils Joseph Swindell
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DOI (Published version): 10.1002/oby.23670
Abstract
Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), P...
| Published in: | Obesity |
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| ISSN: | 1930-7381 1930-739X |
| Published: |
Wiley
2023
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa61804 |
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| Abstract: |
Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), PA, systolic and diastolic blood-pressure (SBP, DBP), heart-rate (HR), plasma HDL-cholesterol-, LDL-cholesterol-, remnant cholesterol (RC)-, triacylglycerol (TAG)-, C-reactive-protein (CRP)-concentrations, were determined in 91 free-living participants (age=56.6±10y;BMI=28.2;HOMA-IR=3.2±3.1) and in 38 participants in sedentary respiration-chamber conditions (age=56.6±10y;BMI=28.5±4.0;HOMA-IR=3.3±1.4). Associations of circadian-rhythm parameters and PA with cardiometabolic-risk factors were determined using factor-analyses followed by Pearson’s correlations. Results: Values of cardiometabolic-risk factors were similar, while circadian-rhythm parameters and PA differed significantly (P<0.05) between conditions. In both conditions, parameters indicating a robust circadian-rhythm associated inversely with CRP and positively with plasma HDL-c-concentrations. In free-living conditions, PA associated inversely with SBP and HR, and positively with HDL-c and robust-circadian-rhythm parameters. In sedentary conditions PA associated positively with HR and inversely with robust-circadian-rhythm parameters. PA mediated the inverse association of parameters indicating a robust circadian rhythm with SBP in free-living conditions.Conclusion: In adults with obesity and prediabetes, parameters indicating a robust circadian-rhythm were, independently of PA, associated with lower cardiometabolic risk and C-reactive-protein. Only in free-living conditions, PA mediated the association of higher circadian-stability with lower SBP. |
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| Keywords: |
Obesity, Prediabetes, Blood-pressure, Lipids/lipoproteins, Inflammation |
| College: |
Faculty of Science and Engineering |
| Issue: |
3 |
| Start Page: |
744 |
| End Page: |
756 |