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Circadian rhythm parameters and physical activity associated with cardiometabolic risk factors in the PREVIEW lifestyle study

Margriet S. Westerterp‐Plantenga Orcid Logo, Mathijs Drummen, Lea Tischmann, Nils Swindell, Gareth Stratton Orcid Logo, Anne Raben, Marit Westerterp, Tanja Adam, Nils Joseph Swindell Orcid Logo

Obesity, Volume: 31, Issue: 3, Pages: 744 - 756

Swansea University Authors: Nils Swindell, Gareth Stratton Orcid Logo, Nils Joseph Swindell Orcid Logo

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DOI (Published version): 10.1002/oby.23670

Abstract

Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), P...

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Published in: Obesity
ISSN: 1930-7381 1930-739X
Published: Wiley 2023
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa61804
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Abstract: Objective: Assessment of post-hoc associations between circadian-rhythm parameters, physical activity (PA) and cardiometabolic-risk factors in adults with obesity and prediabetes after 3-year weight-loss maintenance. Methods: Circadian-rhythm parameters (continuous wrist-temperature measurements), PA, systolic and diastolic blood-pressure (SBP, DBP), heart-rate (HR), plasma HDL-cholesterol-, LDL-cholesterol-, remnant cholesterol (RC)-, triacylglycerol (TAG)-, C-reactive-protein (CRP)-concentrations, were determined in 91 free-living participants (age=56.6±10y;BMI=28.2;HOMA-IR=3.2±3.1) and in 38 participants in sedentary respiration-chamber conditions (age=56.6±10y;BMI=28.5±4.0;HOMA-IR=3.3±1.4). Associations of circadian-rhythm parameters and PA with cardiometabolic-risk factors were determined using factor-analyses followed by Pearson’s correlations. Results: Values of cardiometabolic-risk factors were similar, while circadian-rhythm parameters and PA differed significantly (P<0.05) between conditions. In both conditions, parameters indicating a robust circadian-rhythm associated inversely with CRP and positively with plasma HDL-c-concentrations. In free-living conditions, PA associated inversely with SBP and HR, and positively with HDL-c and robust-circadian-rhythm parameters. In sedentary conditions PA associated positively with HR and inversely with robust-circadian-rhythm parameters. PA mediated the inverse association of parameters indicating a robust circadian rhythm with SBP in free-living conditions.Conclusion: In adults with obesity and prediabetes, parameters indicating a robust circadian-rhythm were, independently of PA, associated with lower cardiometabolic risk and C-reactive-protein. Only in free-living conditions, PA mediated the association of higher circadian-stability with lower SBP.
Keywords: Obesity, Prediabetes, Blood-pressure, Lipids/lipoproteins, Inflammation
College: Faculty of Science and Engineering
Issue: 3
Start Page: 744
End Page: 756