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Reaching the Final Endgame for Constant Waves of COVID-19

Norman Ratcliffe, Helena Carla Castro, Marcelo Salabert Gonzalez, Cicero Brasileiro Mello, Paul Dyson Orcid Logo

Viruses, Volume: 14, Issue: 12, Start page: 2637

Swansea University Authors: Norman Ratcliffe, Paul Dyson Orcid Logo

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DOI (Published version): 10.3390/v14122637

Abstract

Despite intramuscular vaccines saving millions of lives, constant devastating waves of SARS-CoV-2 infections continue. The elimination of COVID-19 is challenging, but necessary in order to avoid millions more people who would suffer from long COVID if we fail. Our paper describes rapidly advancing a...

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Published in: Viruses
ISSN: 1999-4915
Published: MDPI AG 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa62082
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Abstract: Despite intramuscular vaccines saving millions of lives, constant devastating waves of SARS-CoV-2 infections continue. The elimination of COVID-19 is challenging, but necessary in order to avoid millions more people who would suffer from long COVID if we fail. Our paper describes rapidly advancing and innovative therapeutic strategies for the early stage of infection with COVID-19 so that tolerating continuing cycles of infection should be unnecessary in the future. These therapies include new vaccines with broader specificities, nasal therapies and antiviral drugs some targeting COVID-19 at the first stage of infection and preventing the virus entering the body in the first place. Our article describes the advantages and disadvantages of each of these therapeutic options which in various combinations could eventually prevent renewed waves of infection. Finally, important consideration is given to political, social and economic barriers that since 2020 hindered vaccine application and are likely to interfere again with any COVID-19 endgame.
Keywords: SARS-CoV-2; Omicron; COVID-19 elimination; vaccines; nasal therapies; antiviral drugs; new therapeutic options; political and social hindrances
College: Faculty of Medicine, Health and Life Sciences
Funders: The authors received no specific funding for this work.
Issue: 12
Start Page: 2637