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Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

Norman Ratcliffe, João P. Furtado Pacheco, Paul Dyson Orcid Logo, Helena Carla Castro, Marcelo S. Gonzalez, Patricia Azambuja, Cicero B. Mello

Parasites & Vectors, Volume: 15, Issue: 1

Swansea University Authors: Norman Ratcliffe, Paul Dyson Orcid Logo

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Abstract

This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by...

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Published in: Parasites & Vectors
ISSN: 1756-3305
Published: Springer Science and Business Media LLC 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59749
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Abstract: This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered.
Keywords: Paratrangenesis, Microbiome, Insect vectors, Mosquitoes, Triatomines, Tsetse fies, Sandfies,Environmental safety, Pest control
College: Swansea University Medical School
Funders: This work was supported by CAPES processo No. 88881.068062/2014-01
Issue: 1