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Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
Parasites & Vectors, Volume: 15, Issue: 1
Swansea University Authors:
Norman Ratcliffe, Paul Dyson
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DOI (Published version): 10.1186/s13071-021-05132-3
Abstract
This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by...
Published in: | Parasites & Vectors |
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ISSN: | 1756-3305 |
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Springer Science and Business Media LLC
2022
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URI: | https://cronfa.swan.ac.uk/Record/cronfa59749 |
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2022-04-20T14:18:58.5166314 v2 59749 2022-03-31 Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors aebb70dc95237305e0a8f4bb80b5ef22 Norman Ratcliffe Norman Ratcliffe true false 300e3f46b70ae83f563b24f41d00cd17 0000-0002-0558-2666 Paul Dyson Paul Dyson true false 2022-03-31 FGSEN This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered. Journal Article Parasites & Vectors 15 1 Springer Science and Business Media LLC 1756-3305 Paratrangenesis, Microbiome, Insect vectors, Mosquitoes, Triatomines, Tsetse fies, Sandfies,Environmental safety, Pest control 31 3 2022 2022-03-31 10.1186/s13071-021-05132-3 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University Another institution paid the OA fee This work was supported by CAPES processo No. 88881.068062/2014-01 2022-04-20T14:18:58.5166314 2022-03-31T14:38:02.5676124 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Norman Ratcliffe 1 João P. Furtado Pacheco 2 Paul Dyson 0000-0002-0558-2666 3 Helena Carla Castro 4 Marcelo S. Gonzalez 5 Patricia Azambuja 6 Cicero B. Mello 7 59749__23897__19fb6ca2ead84ede88161f79a0da8111.pdf 59749.pdf 2022-04-20T14:16:06.3064523 Output 2555838 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/ |
title |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors |
spellingShingle |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors Norman Ratcliffe Paul Dyson |
title_short |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors |
title_full |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors |
title_fullStr |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors |
title_full_unstemmed |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors |
title_sort |
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors |
author_id_str_mv |
aebb70dc95237305e0a8f4bb80b5ef22 300e3f46b70ae83f563b24f41d00cd17 |
author_id_fullname_str_mv |
aebb70dc95237305e0a8f4bb80b5ef22_***_Norman Ratcliffe 300e3f46b70ae83f563b24f41d00cd17_***_Paul Dyson |
author |
Norman Ratcliffe Paul Dyson |
author2 |
Norman Ratcliffe João P. Furtado Pacheco Paul Dyson Helena Carla Castro Marcelo S. Gonzalez Patricia Azambuja Cicero B. Mello |
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Journal article |
container_title |
Parasites & Vectors |
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15 |
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1 |
publishDate |
2022 |
institution |
Swansea University |
issn |
1756-3305 |
doi_str_mv |
10.1186/s13071-021-05132-3 |
publisher |
Springer Science and Business Media LLC |
college_str |
Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
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Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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description |
This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered. |
published_date |
2022-03-31T04:17:17Z |
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1763754154883284992 |
score |
11.021648 |