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Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

Norman Ratcliffe, João P. Furtado Pacheco, Paul Dyson Orcid Logo, Helena Carla Castro, Marcelo S. Gonzalez, Patricia Azambuja, Cicero B. Mello

Parasites & Vectors, Volume: 15, Issue: 1

Swansea University Authors: Norman Ratcliffe, Paul Dyson Orcid Logo

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DOI (Published version): 10.1186/s13071-021-05132-3

Abstract

This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by...

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Published in: Parasites & Vectors
ISSN: 1756-3305
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59749
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first_indexed 2022-03-31T13:44:36Z
last_indexed 2022-04-21T03:30:52Z
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spelling 2022-04-20T14:18:58.5166314 v2 59749 2022-03-31 Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors aebb70dc95237305e0a8f4bb80b5ef22 Norman Ratcliffe Norman Ratcliffe true false 300e3f46b70ae83f563b24f41d00cd17 0000-0002-0558-2666 Paul Dyson Paul Dyson true false 2022-03-31 FGSEN This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered. Journal Article Parasites &amp; Vectors 15 1 Springer Science and Business Media LLC 1756-3305 Paratrangenesis, Microbiome, Insect vectors, Mosquitoes, Triatomines, Tsetse fies, Sandfies,Environmental safety, Pest control 31 3 2022 2022-03-31 10.1186/s13071-021-05132-3 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University Another institution paid the OA fee This work was supported by CAPES processo No. 88881.068062/2014-01 2022-04-20T14:18:58.5166314 2022-03-31T14:38:02.5676124 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Norman Ratcliffe 1 João P. Furtado Pacheco 2 Paul Dyson 0000-0002-0558-2666 3 Helena Carla Castro 4 Marcelo S. Gonzalez 5 Patricia Azambuja 6 Cicero B. Mello 7 59749__23897__19fb6ca2ead84ede88161f79a0da8111.pdf 59749.pdf 2022-04-20T14:16:06.3064523 Output 2555838 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
spellingShingle Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
Norman Ratcliffe
Paul Dyson
title_short Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_full Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_fullStr Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_full_unstemmed Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_sort Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
author_id_str_mv aebb70dc95237305e0a8f4bb80b5ef22
300e3f46b70ae83f563b24f41d00cd17
author_id_fullname_str_mv aebb70dc95237305e0a8f4bb80b5ef22_***_Norman Ratcliffe
300e3f46b70ae83f563b24f41d00cd17_***_Paul Dyson
author Norman Ratcliffe
Paul Dyson
author2 Norman Ratcliffe
João P. Furtado Pacheco
Paul Dyson
Helena Carla Castro
Marcelo S. Gonzalez
Patricia Azambuja
Cicero B. Mello
format Journal article
container_title Parasites &amp; Vectors
container_volume 15
container_issue 1
publishDate 2022
institution Swansea University
issn 1756-3305
doi_str_mv 10.1186/s13071-021-05132-3
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered.
published_date 2022-03-31T04:17:17Z
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