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Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review

Daniel Morris, Micah Flores Orcid Logo, Llinos Harris Orcid Logo, John Gammon Orcid Logo, Yamni Nigam

Microorganisms, Volume: 11, Issue: 2, Start page: 457

Swansea University Authors: Llinos Harris Orcid Logo, John Gammon Orcid Logo, Yamni Nigam

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DOI (Published version): 10.3390/microorganisms11020457

Abstract

Chronic wounds present a global healthcare challenge and are increasing in prevalence, with bacterial biofilms being the primary roadblock to healing in most cases. A systematic review of the to-date knowledge on larval therapy’s interaction with chronic-wound biofilm is presented here. The findings...

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Published in: Microorganisms
ISSN: 2076-2607
Published: MDPI AG 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa62718
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first_indexed 2023-02-23T09:14:56Z
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A Systematic Review</title><swanseaauthors><author><sid>dc70f9d4badbbdb5d467fd321986d173</sid><ORCID>0000-0002-0295-3038</ORCID><firstname>Llinos</firstname><surname>Harris</surname><name>Llinos Harris</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cda6690a73656beb65710ac68296c980</sid><ORCID>0000-0001-5707-5503</ORCID><firstname>John</firstname><surname>Gammon</surname><name>John Gammon</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>16d566efd3e2b483b5f08651f5515efb</sid><firstname>Yamni</firstname><surname>Nigam</surname><name>Yamni Nigam</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-02-23</date><deptcode>BMS</deptcode><abstract>Chronic wounds present a global healthcare challenge and are increasing in prevalence, with bacterial biofilms being the primary roadblock to healing in most cases. A systematic review of the to-date knowledge on larval therapy&#x2019;s interaction with chronic-wound biofilm is presented here. The findings detail how larval therapy&#x2014;the controlled application of necrophagous blowfly larvae&#x2014;acts on biofilms produced by chronic-wound-relevant bacteria through their principle pharmacological mode of action: the secretion and excretion of biologically active substances into the wound bed. A total of 12 inclusion-criteria-meeting publications were identified following the application of a PRISMA-guided methodology for a systematic review. The findings of these publications were qualitatively analyzed to provide a summary of the prevailing understanding of larval therapy&#x2019;s effects on bacterial biofilm. A further review assessed the quality of the existing evidence to identify knowledge gaps and suggest ways these may be bridged. In summary, larval therapy has a seemingly unarguable ability to inhibit and degrade bacterial biofilms associated with impaired wound healing. However, further research is needed to clarify and standardize the methodological approach in this area of investigation. 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spelling 2023-03-08T17:36:10.6830547 v2 62718 2023-02-23 Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review dc70f9d4badbbdb5d467fd321986d173 0000-0002-0295-3038 Llinos Harris Llinos Harris true false cda6690a73656beb65710ac68296c980 0000-0001-5707-5503 John Gammon John Gammon true false 16d566efd3e2b483b5f08651f5515efb Yamni Nigam Yamni Nigam true false 2023-02-23 BMS Chronic wounds present a global healthcare challenge and are increasing in prevalence, with bacterial biofilms being the primary roadblock to healing in most cases. A systematic review of the to-date knowledge on larval therapy’s interaction with chronic-wound biofilm is presented here. The findings detail how larval therapy—the controlled application of necrophagous blowfly larvae—acts on biofilms produced by chronic-wound-relevant bacteria through their principle pharmacological mode of action: the secretion and excretion of biologically active substances into the wound bed. A total of 12 inclusion-criteria-meeting publications were identified following the application of a PRISMA-guided methodology for a systematic review. The findings of these publications were qualitatively analyzed to provide a summary of the prevailing understanding of larval therapy’s effects on bacterial biofilm. A further review assessed the quality of the existing evidence to identify knowledge gaps and suggest ways these may be bridged. In summary, larval therapy has a seemingly unarguable ability to inhibit and degrade bacterial biofilms associated with impaired wound healing. However, further research is needed to clarify and standardize the methodological approach in this area of investigation. Such research may lead to the clinical application of larval therapy or derivative treatments for the management of chronic-wound biofilms and improve patient healing outcomes at a time when alternative therapies are desperately needed. Journal Article Microorganisms 11 2 457 MDPI AG 2076-2607 chronic wound; biofilm; larval therapy; wound healing; Staphylococcus aureus; Pseudomonas aeruginosa; Lucilia sericata; maggot therapy 11 2 2023 2023-02-11 10.3390/microorganisms11020457 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Another institution paid the OA fee This research was undertaken as part of a PhD research program at Swansea University sponsored by BioMonde. 2023-03-08T17:36:10.6830547 2023-02-23T09:12:22.4357105 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Healthcare Science Daniel Morris 1 Micah Flores 0000-0001-9580-5239 2 Llinos Harris 0000-0002-0295-3038 3 John Gammon 0000-0001-5707-5503 4 Yamni Nigam 5 62718__26780__4cd3b4a700eb4979aa0f4f77edfc643e.pdf 62718_VoR.pdf 2023-03-08T17:33:22.7798568 Output 648293 application/pdf Version of Record true © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license true eng https://creativecommons.org/licenses/by/4.0/
title Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
spellingShingle Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
Llinos Harris
John Gammon
Yamni Nigam
title_short Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
title_full Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
title_fullStr Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
title_full_unstemmed Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
title_sort Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
author_id_str_mv dc70f9d4badbbdb5d467fd321986d173
cda6690a73656beb65710ac68296c980
16d566efd3e2b483b5f08651f5515efb
author_id_fullname_str_mv dc70f9d4badbbdb5d467fd321986d173_***_Llinos Harris
cda6690a73656beb65710ac68296c980_***_John Gammon
16d566efd3e2b483b5f08651f5515efb_***_Yamni Nigam
author Llinos Harris
John Gammon
Yamni Nigam
author2 Daniel Morris
Micah Flores
Llinos Harris
John Gammon
Yamni Nigam
format Journal article
container_title Microorganisms
container_volume 11
container_issue 2
container_start_page 457
publishDate 2023
institution Swansea University
issn 2076-2607
doi_str_mv 10.3390/microorganisms11020457
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Healthcare Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Healthcare Science
document_store_str 1
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description Chronic wounds present a global healthcare challenge and are increasing in prevalence, with bacterial biofilms being the primary roadblock to healing in most cases. A systematic review of the to-date knowledge on larval therapy’s interaction with chronic-wound biofilm is presented here. The findings detail how larval therapy—the controlled application of necrophagous blowfly larvae—acts on biofilms produced by chronic-wound-relevant bacteria through their principle pharmacological mode of action: the secretion and excretion of biologically active substances into the wound bed. A total of 12 inclusion-criteria-meeting publications were identified following the application of a PRISMA-guided methodology for a systematic review. The findings of these publications were qualitatively analyzed to provide a summary of the prevailing understanding of larval therapy’s effects on bacterial biofilm. A further review assessed the quality of the existing evidence to identify knowledge gaps and suggest ways these may be bridged. In summary, larval therapy has a seemingly unarguable ability to inhibit and degrade bacterial biofilms associated with impaired wound healing. However, further research is needed to clarify and standardize the methodological approach in this area of investigation. Such research may lead to the clinical application of larval therapy or derivative treatments for the management of chronic-wound biofilms and improve patient healing outcomes at a time when alternative therapies are desperately needed.
published_date 2023-02-11T04:23:02Z
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