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COVID-19 vaccination uptake in people with epilepsy in wales

Huw Strafford, Arron S. Lacey Orcid Logo, Joe Hollinghurst, Ashley Akbari Orcid Logo, Alan Watkins Orcid Logo, J. Paterson, D. Jennings, Ronan Lyons Orcid Logo, Robert Powell, M.P. Kerr, R.W. Chin, Owen Pickrell Orcid Logo

Seizure, Volume: 108, Pages: 49 - 52

Swansea University Authors: Huw Strafford, Arron S. Lacey Orcid Logo, Joe Hollinghurst, Ashley Akbari Orcid Logo, Alan Watkins Orcid Logo, Ronan Lyons Orcid Logo, Robert Powell, Owen Pickrell Orcid Logo

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Abstract

Purpose: People with epilepsy (PWE) are at increased risk of severe COVID-19. Assessing COVID-19 vaccine uptake is therefore important. We compared COVID-19 vaccination uptake for PWE in Wales with a matched control cohort. Methods: We performed a retrospective, population, cohort study using linked...

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Published in: Seizure
ISSN: 1059-1311
Published: Elsevier BV 2023
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa63099
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Abstract: Purpose: People with epilepsy (PWE) are at increased risk of severe COVID-19. Assessing COVID-19 vaccine uptake is therefore important. We compared COVID-19 vaccination uptake for PWE in Wales with a matched control cohort. Methods: We performed a retrospective, population, cohort study using linked, anonymised, Welsh electronic health records within the Secure Anonymised Information Linkage (SAIL) Databank (Welsh population=3.1 million).We identified PWE in Wales between 1st March 2020 and 31st December 2021 and created a control cohort using exact 5:1 matching (sex, age and socioeconomic status). We recorded 1st, 2nd and booster COVID-19 vaccinations.Results: There were 25,404 adults with epilepsy (127,020 controls). 23,454 (92.3%) had a first vaccination, 22,826 (89.9%) a second, and 17,797 (70.1%) a booster. Comparative figures for controls were: 112,334 (87.8%), 109,057 (85.2%) and 79,980 (62.4%).PWE had higher vaccination rates in all age, sex and socioeconomic subgroups apart from booster uptake in older subgroups. Vaccination rates were higher in older subgroups, women and less deprived areas for both cohorts. People with intellectual disability and epilepsy had higher vaccination rates when compared with controls with intellectual disability. Conclusions: COVID-19 vaccination uptake for PWE in Wales was higher than that for a matched control group.
Keywords: Data Linkage, Electronic Health Records, Pandemic, COVID-19, Epilepsy, Vaccination
College: Faculty of Medicine, Health and Life Sciences
Funders: Health and Care Research Wales. Supported by Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-9006) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. JH was supported by Health and Care research Wales [Project: SCF-18-1504]. AA, JH and RL were supported by the con-cov grant funded by the Medical Research Council (grant number: MR/V028367/1), ADR Wales programme of work funded by the ADR UK (grant ES/S007393/1) and the Wales COVID-19 Evidence Centre, funded by Health and Care Research Wales. This study makes use of anonymised data held in the Secure Anonymised Information Linkage (SAIL) Databank.
Start Page: 49
End Page: 52