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COVID-19 vaccination uptake in people with epilepsy in wales

Huw Strafford, Arron S. Lacey Orcid Logo, Joseph Hollinghurst, Ashley Akbari Orcid Logo, Alan Watkins Orcid Logo, J. Paterson, D. Jennings, Ronan Lyons Orcid Logo, Robert Powell, M.P. Kerr, R.W. Chin, Owen Pickrell Orcid Logo

Seizure, Volume: 108, Pages: 49 - 52

Swansea University Authors: Huw Strafford, Arron S. Lacey Orcid Logo, Joseph Hollinghurst, Ashley Akbari Orcid Logo, Alan Watkins Orcid Logo, Ronan Lyons Orcid Logo, Robert Powell, Owen Pickrell Orcid Logo

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DOI (Published version): 10.1016/j.seizure.2023.04.006

Abstract

Purpose: People with epilepsy (PWE) are at increased risk of severe COVID-19. Assessing COVID-19 vaccine uptake is therefore important. We compared COVID-19 vaccination uptake for PWE in Wales with a matched control cohort. Methods: We performed a retrospective, population, cohort study using linked...

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Published in: Seizure
ISSN: 1059-1311
Published: Elsevier BV 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63099
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Lacey</name><active>true</active><ethesisStudent>true</ethesisStudent></author><author><sid>d7c51b69270b644a11b904629fe56ab0</sid><firstname>Joseph</firstname><surname>Hollinghurst</surname><name>Joseph Hollinghurst</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>aa1b025ec0243f708bb5eb0a93d6fb52</sid><ORCID>0000-0003-0814-0801</ORCID><firstname>Ashley</firstname><surname>Akbari</surname><name>Ashley Akbari</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>81fc05c9333d9df41b041157437bcc2f</sid><ORCID>0000-0003-3804-1943</ORCID><firstname>Alan</firstname><surname>Watkins</surname><name>Alan Watkins</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>83efcf2a9dfcf8b55586999d3d152ac6</sid><ORCID>0000-0001-5225-000X</ORCID><firstname>Ronan</firstname><surname>Lyons</surname><name>Ronan Lyons</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>7c8ac48bb6ae4281930e4138f94a51b6</sid><firstname>Robert</firstname><surname>Powell</surname><name>Robert Powell</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>1c3044b5ff7a6552ff5e8c9e3901c807</sid><ORCID>0000-0003-4396-5657</ORCID><firstname>Owen</firstname><surname>Pickrell</surname><name>Owen Pickrell</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-04-08</date><deptcode>MEDS</deptcode><abstract>Purpose: People with epilepsy (PWE) are at increased risk of severe COVID-19. Assessing COVID-19 vaccine uptake is therefore important. We compared COVID-19 vaccination uptake for PWE in Wales with a matched control cohort. Methods: We performed a retrospective, population, cohort study using linked, anonymised, Welsh electronic health records within the Secure Anonymised Information Linkage (SAIL) Databank (Welsh population=3.1 million).We identified PWE in Wales between 1st March 2020 and 31st December 2021 and created a control cohort using exact 5:1 matching (sex, age and socioeconomic status). We recorded 1st, 2nd and booster COVID-19 vaccinations.Results: There were 25,404 adults with epilepsy (127,020 controls). 23,454 (92.3%) had a first vaccination, 22,826 (89.9%) a second, and 17,797 (70.1%) a booster. Comparative figures for controls were: 112,334 (87.8%), 109,057 (85.2%) and 79,980 (62.4%).PWE had higher vaccination rates in all age, sex and socioeconomic subgroups apart from booster uptake in older subgroups. Vaccination rates were higher in older subgroups, women and less deprived areas for both cohorts. People with intellectual disability and epilepsy had higher vaccination rates when compared with controls with intellectual disability. Conclusions: COVID-19 vaccination uptake for PWE in Wales was higher than that for a matched control group.</abstract><type>Journal Article</type><journal>Seizure</journal><volume>108</volume><journalNumber/><paginationStart>49</paginationStart><paginationEnd>52</paginationEnd><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1059-1311</issnPrint><issnElectronic/><keywords>Data Linkage, Electronic Health Records, Pandemic, COVID-19, Epilepsy, Vaccination</keywords><publishedDay>1</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-05-01</publishedDate><doi>10.1016/j.seizure.2023.04.006</doi><url>http://dx.doi.org/10.1016/j.seizure.2023.04.006</url><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>Health and Care Research Wales. Supported by Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-9006) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. JH was supported by Health and Care research Wales [Project: SCF-18-1504]. AA, JH and RL were supported by the con-cov grant funded by the Medical Research Council (grant number: MR/V028367/1), ADR Wales programme of work funded by the ADR UK (grant ES/S007393/1) and the Wales COVID-19 Evidence Centre, funded by Health and Care Research Wales. This study makes use of anonymised data held in the Secure Anonymised Information Linkage (SAIL) Databank.</funders><projectreference/><lastEdited>2023-05-18T14:48:57.1745129</lastEdited><Created>2023-04-08T15:17:22.0518307</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Huw</firstname><surname>Strafford</surname><order>1</order></author><author><firstname>Arron S.</firstname><surname>Lacey</surname><orcid>0000-0001-7983-8073</orcid><order>2</order></author><author><firstname>Joseph</firstname><surname>Hollinghurst</surname><order>3</order></author><author><firstname>Ashley</firstname><surname>Akbari</surname><orcid>0000-0003-0814-0801</orcid><order>4</order></author><author><firstname>Alan</firstname><surname>Watkins</surname><orcid>0000-0003-3804-1943</orcid><order>5</order></author><author><firstname>J.</firstname><surname>Paterson</surname><order>6</order></author><author><firstname>D.</firstname><surname>Jennings</surname><order>7</order></author><author><firstname>Ronan</firstname><surname>Lyons</surname><orcid>0000-0001-5225-000X</orcid><order>8</order></author><author><firstname>Robert</firstname><surname>Powell</surname><order>9</order></author><author><firstname>M.P.</firstname><surname>Kerr</surname><order>10</order></author><author><firstname>R.W.</firstname><surname>Chin</surname><order>11</order></author><author><firstname>Owen</firstname><surname>Pickrell</surname><orcid>0000-0003-4396-5657</orcid><order>12</order></author></authors><documents><document><filename>63099__27170__6453ff85a8cb40788c4944c3209a2b88.pdf</filename><originalFilename>63099.VOR.pdf</originalFilename><uploaded>2023-04-21T16:36:36.5643871</uploaded><type>Output</type><contentLength>1058028</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Distributed under the terms of a Creative Commons Attribution 4.0 License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2023-05-18T14:48:57.1745129 v2 63099 2023-04-08 COVID-19 vaccination uptake in people with epilepsy in wales a6389fc6d4d18e7b67033ee04b381e43 Huw Strafford Huw Strafford true false 7af5c8bdd1197f85720e4f3d65e803eb 0000-0001-7983-8073 Arron S. Lacey Arron S. Lacey true true d7c51b69270b644a11b904629fe56ab0 Joseph Hollinghurst Joseph Hollinghurst true false aa1b025ec0243f708bb5eb0a93d6fb52 0000-0003-0814-0801 Ashley Akbari Ashley Akbari true false 81fc05c9333d9df41b041157437bcc2f 0000-0003-3804-1943 Alan Watkins Alan Watkins true false 83efcf2a9dfcf8b55586999d3d152ac6 0000-0001-5225-000X Ronan Lyons Ronan Lyons true false 7c8ac48bb6ae4281930e4138f94a51b6 Robert Powell Robert Powell true false 1c3044b5ff7a6552ff5e8c9e3901c807 0000-0003-4396-5657 Owen Pickrell Owen Pickrell true false 2023-04-08 MEDS Purpose: People with epilepsy (PWE) are at increased risk of severe COVID-19. Assessing COVID-19 vaccine uptake is therefore important. We compared COVID-19 vaccination uptake for PWE in Wales with a matched control cohort. Methods: We performed a retrospective, population, cohort study using linked, anonymised, Welsh electronic health records within the Secure Anonymised Information Linkage (SAIL) Databank (Welsh population=3.1 million).We identified PWE in Wales between 1st March 2020 and 31st December 2021 and created a control cohort using exact 5:1 matching (sex, age and socioeconomic status). We recorded 1st, 2nd and booster COVID-19 vaccinations.Results: There were 25,404 adults with epilepsy (127,020 controls). 23,454 (92.3%) had a first vaccination, 22,826 (89.9%) a second, and 17,797 (70.1%) a booster. Comparative figures for controls were: 112,334 (87.8%), 109,057 (85.2%) and 79,980 (62.4%).PWE had higher vaccination rates in all age, sex and socioeconomic subgroups apart from booster uptake in older subgroups. Vaccination rates were higher in older subgroups, women and less deprived areas for both cohorts. People with intellectual disability and epilepsy had higher vaccination rates when compared with controls with intellectual disability. Conclusions: COVID-19 vaccination uptake for PWE in Wales was higher than that for a matched control group. Journal Article Seizure 108 49 52 Elsevier BV 1059-1311 Data Linkage, Electronic Health Records, Pandemic, COVID-19, Epilepsy, Vaccination 1 5 2023 2023-05-01 10.1016/j.seizure.2023.04.006 http://dx.doi.org/10.1016/j.seizure.2023.04.006 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) Health and Care Research Wales. Supported by Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-9006) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. JH was supported by Health and Care research Wales [Project: SCF-18-1504]. AA, JH and RL were supported by the con-cov grant funded by the Medical Research Council (grant number: MR/V028367/1), ADR Wales programme of work funded by the ADR UK (grant ES/S007393/1) and the Wales COVID-19 Evidence Centre, funded by Health and Care Research Wales. This study makes use of anonymised data held in the Secure Anonymised Information Linkage (SAIL) Databank. 2023-05-18T14:48:57.1745129 2023-04-08T15:17:22.0518307 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Huw Strafford 1 Arron S. Lacey 0000-0001-7983-8073 2 Joseph Hollinghurst 3 Ashley Akbari 0000-0003-0814-0801 4 Alan Watkins 0000-0003-3804-1943 5 J. Paterson 6 D. Jennings 7 Ronan Lyons 0000-0001-5225-000X 8 Robert Powell 9 M.P. Kerr 10 R.W. Chin 11 Owen Pickrell 0000-0003-4396-5657 12 63099__27170__6453ff85a8cb40788c4944c3209a2b88.pdf 63099.VOR.pdf 2023-04-21T16:36:36.5643871 Output 1058028 application/pdf Version of Record true Distributed under the terms of a Creative Commons Attribution 4.0 License. true eng https://creativecommons.org/licenses/by/4.0/
title COVID-19 vaccination uptake in people with epilepsy in wales
spellingShingle COVID-19 vaccination uptake in people with epilepsy in wales
Huw Strafford
Arron S. Lacey
Joseph Hollinghurst
Ashley Akbari
Alan Watkins
Ronan Lyons
Robert Powell
Owen Pickrell
title_short COVID-19 vaccination uptake in people with epilepsy in wales
title_full COVID-19 vaccination uptake in people with epilepsy in wales
title_fullStr COVID-19 vaccination uptake in people with epilepsy in wales
title_full_unstemmed COVID-19 vaccination uptake in people with epilepsy in wales
title_sort COVID-19 vaccination uptake in people with epilepsy in wales
author_id_str_mv a6389fc6d4d18e7b67033ee04b381e43
7af5c8bdd1197f85720e4f3d65e803eb
d7c51b69270b644a11b904629fe56ab0
aa1b025ec0243f708bb5eb0a93d6fb52
81fc05c9333d9df41b041157437bcc2f
83efcf2a9dfcf8b55586999d3d152ac6
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1c3044b5ff7a6552ff5e8c9e3901c807
author_id_fullname_str_mv a6389fc6d4d18e7b67033ee04b381e43_***_Huw Strafford
7af5c8bdd1197f85720e4f3d65e803eb_***_Arron S. Lacey
d7c51b69270b644a11b904629fe56ab0_***_Joseph Hollinghurst
aa1b025ec0243f708bb5eb0a93d6fb52_***_Ashley Akbari
81fc05c9333d9df41b041157437bcc2f_***_Alan Watkins
83efcf2a9dfcf8b55586999d3d152ac6_***_Ronan Lyons
7c8ac48bb6ae4281930e4138f94a51b6_***_Robert Powell
1c3044b5ff7a6552ff5e8c9e3901c807_***_Owen Pickrell
author Huw Strafford
Arron S. Lacey
Joseph Hollinghurst
Ashley Akbari
Alan Watkins
Ronan Lyons
Robert Powell
Owen Pickrell
author2 Huw Strafford
Arron S. Lacey
Joseph Hollinghurst
Ashley Akbari
Alan Watkins
J. Paterson
D. Jennings
Ronan Lyons
Robert Powell
M.P. Kerr
R.W. Chin
Owen Pickrell
format Journal article
container_title Seizure
container_volume 108
container_start_page 49
publishDate 2023
institution Swansea University
issn 1059-1311
doi_str_mv 10.1016/j.seizure.2023.04.006
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://dx.doi.org/10.1016/j.seizure.2023.04.006
document_store_str 1
active_str 0
description Purpose: People with epilepsy (PWE) are at increased risk of severe COVID-19. Assessing COVID-19 vaccine uptake is therefore important. We compared COVID-19 vaccination uptake for PWE in Wales with a matched control cohort. Methods: We performed a retrospective, population, cohort study using linked, anonymised, Welsh electronic health records within the Secure Anonymised Information Linkage (SAIL) Databank (Welsh population=3.1 million).We identified PWE in Wales between 1st March 2020 and 31st December 2021 and created a control cohort using exact 5:1 matching (sex, age and socioeconomic status). We recorded 1st, 2nd and booster COVID-19 vaccinations.Results: There were 25,404 adults with epilepsy (127,020 controls). 23,454 (92.3%) had a first vaccination, 22,826 (89.9%) a second, and 17,797 (70.1%) a booster. Comparative figures for controls were: 112,334 (87.8%), 109,057 (85.2%) and 79,980 (62.4%).PWE had higher vaccination rates in all age, sex and socioeconomic subgroups apart from booster uptake in older subgroups. Vaccination rates were higher in older subgroups, women and less deprived areas for both cohorts. People with intellectual disability and epilepsy had higher vaccination rates when compared with controls with intellectual disability. Conclusions: COVID-19 vaccination uptake for PWE in Wales was higher than that for a matched control group.
published_date 2023-05-01T02:33:18Z
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