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Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Callum Jackson, Iain D Stewart, Tatiana Plekhanova, Peter S Cunningham, Andrew L Hazel, Bashar Al-Sheklly, Raminder Aul, Charlotte E Bolton, Trudie Chalder, James D Chalmers, Nazia Chaudhuri, Annemarie B Docherty, Gavin Donaldson, Charlotte L Edwardson, Omer Elneima, Neil J Greening, Neil A Hanley, Victoria C Harris, Ewen M Harrison, Ling-Pei Ho, Linzy Houchen-Wolloff, Luke S Howard, Caroline J Jolley, Mark G Jones, Olivia C Leavy, Keir Lewis Orcid Logo, Nazir I Lone, Michael Marks, Hamish J C McAuley, Melitta McNarry Orcid Logo, Brijesh V Patel, Karen Piper-Hanley, Krisnah Poinasamy, Betty Raman, Matthew Richardson, Pilar Rivera-Ortega, Sarah L Rowland-Jones, Alex V Rowlands, Ruth M Saunders, Janet T Scott, Marco Sereno, Ajay M Shah, Aarti Shikotra, Amisha Singapuri, Stefan C Stanel, Mathew Thorpe, Daniel G Wootton, Thomas Yates, R Gisli Jenkins, Sally J Singh, William D-C Man, Christopher E Brightling, Louise V Wain, Joanna C Porter, A A Roger Thompson, Alex Horsley, Philip L Molyneaux, Rachael A Evans, Samuel E Jones, Martin K Rutter, John F Blaikley, C Jackson, I D Stewart, T Plekhanova, P S Cunningham, A L Hazel, B Al-Sheklly, R Aul, C E Bolton, T Chalder, J D Chalmers, N Chaudhuri, A B Docherty, G Donaldson, C L Edwardson, O Elneima, N J Greening, N A Hanley, V C Harris, E M Harrison, L-P Ho, L Houchen-Wolloff, L S Howard, C J Jolley, M G Jones, O C Leavy, K E Lewis, N I Lone, M Marks, H J C McAuley, M A McNarry, B Patel, K Piper-Hanley, K Poinasamy, B Raman, M Richardson, P Rivera-Ortega, S L Rowland-Jones, A V Rowlands, R M Saunders, J T Scott, M Sereno, A M Shah, A Shikotra, A Singapuri, S C Stanel, M Thorpe, D G Wootton, T Yates, G Jenkins, S J Singh, W D-C Man, C E Brightling, L V Wain, J C Porter, R Thompson, A Horsley, P L Molyneaux, R A Evans, S E Jones, M K Rutter, J F Blaikley, K Abel, H Adamali, D Adeloye, O Adeyemi, R Adrego, L A Aguilar Jimenez, S Ahmad, N Ahmad Haider, R Ahmed, N Ahwireng, M Ainsworth, B Al-Sheklly, A Alamoudi, M Ali, M Aljaroof, AM All, L Allan, R J Allen, L Allerton, L Allsop, P Almeida, D Altmann, M Alvarez Corral, S Amoils, D Anderson, C Antoniades, G Arbane, A Arias, C Armour, L Armstrong, N Armstrong, D Arnold, H Arnold, A Ashish, A Ashworth, M Ashworth, S Aslani, H Assefa-Kebede, C Atkin, P Atkin, H Aung, L Austin, C Avram, A Ayoub, M Babores, R Baggott, J Bagshaw, D Baguley, L Bailey, J K Baillie, S Bain, M Bakali, M Bakau, E Baldry, D Baldwin, M Baldwin, C Ballard, A Banerjee, B Bang, R E Barker, L Barman, S Barratt, F Barrett, D Basire, N Basu, M Bates, A Bates, R Batterham, H Baxendale, H Bayes, M Beadsworth, P Beckett, M Beggs, M Begum, P Beirne, D Bell, R Bell, K Bennett, E Beranova, A Bermperi, A Berridge, C Berry, S Betts, E Bevan, K Bhui, M Bingham, K Birchall, L Bishop, K Bisnauthsing, J Blaikely, A Bloss, A Bolger, J Bonnington, A Botkai, C Bourne, M Bourne, K Bramham, L Brear, G Breen, J Breeze, A Briggs, E Bright, S Brill, K Brindle, L Broad, A Broadley, C Brookes, M Broome, A Brown, J Brown, J S Brown, M Brown, V Brown, T Brugha, N Brunskill, M Buch, P Buckley, A Bularga, E Bullmore, L Burden, T Burdett, D Burn, G Burns, A Burns, J Busby, R Butcher, A Butt, S Byrne, P Cairns, P C Calder, E Calvelo, H Carborn, B Card, C Carr, L Carr, G Carson, P Carter, A Casey, M Cassar, J Cavanagh, M Chablani, R C Chambers, F Chan, K M Channon, K Chapman, A Charalambou, A Checkley, J Chen, Y Cheng, L Chetham, C Childs, E R Chilvers, H Chinoy, A Chiribiri, K Chong-James, G Choudhury, N Choudhury, P Chowienczyk, C Christie, M Chrystal, D Clark, C Clark, J Clarke, S Clohisey, G Coakley, Z Coburn, S Coetzee, J Cole, C Coleman, F Conneh, D Connell, B Connolly, L Connor, A Cook, B Cooper, J Cooper, S Cooper, D Copeland, T Cosier, M Coulding, C Coupland, E Cox, T Craig, P Crisp, D Cristiano, M G Crooks, A Cross, I Cruz, P Cullinan, D Cuthbertson, L Daines, M Dalton, P Daly, A Daniels, P Dark, J Dasgin, A David, C David, E Davies, F Davies, G Davies, G A Davies, K Davies, M J Davies, J Dawson, E Daynes, A De Soyza, B Deakin, A Deans, C Deas, J Deery, S Defres, A Dell, K Dempsey, E Denneny, J Dennis, A Dewar, R Dharmagunawardena, N Diar-Bakerly, C Dickens, A Dipper, S Diver, S N Diwanji, M Dixon, R Djukanovic, H Dobson, S L Dobson, A Donaldson, T Dong, N Dormand, A Dougherty, R Dowling, S Drain, K Draxlbauer, K Drury, P Dulawan, A Dunleavy, S Dunn, C Dupont, J Earley, N Easom, C Echevarria, S Edwards, C Edwardson, H El-Taweel, A Elliott, K Elliott, Y Ellis, A Elmer, D Evans, H Evans, J Evans, R Evans, R I Evans, T Evans, C Evenden, L Evison, L Fabbri, S Fairbairn, A Fairman, K Fallon, D Faluyi, C Favager, T Fayzan, J Featherstone, T Felton, J Finch, S Finney, J Finnigan, L Finnigan, H Fisher, S Fletcher, R Flockton, M Flynn, H Foot, D Foote, A Ford, D Forton, E Fraile, C Francis, R Francis, S Francis, A Frankel, E Fraser, R Free, N French, X Fu, J Fuld, J Furniss, L Garner, N Gautam, J R Geddes, J George, P M George, M Gibbons, M Gill, L Gilmour, F Gleeson, J Glossop, S Glover, N Goodman, C Goodwin, B Gooptu, H Gordon, T Gorsuch, M Greatorex, P L Greenhaff, W Greenhalf, A Greenhalgh, J Greenwood, H Gregory, R Gregory, D Grieve, D Griffin, L Griffiths, A-M Guerdette, B Guillen Guio, M Gummadi, A Gupta, S Gurram, E Guthrie, Z Guy, H Henson, K Hadley, A Haggar, K Hainey, B Hairsine, P Haldar, I Hall, L Hall, M Halling-Brown, R Hamil, A Hancock, K Hancock, S Haq, H E Hardwick, E Hardy, T Hardy, B Hargadon, K Harrington, E Harris, P Harrison, N Hart, A Harvey, M Harvey, M Harvie, L Haslam, M Havinden-Williams, J Hawkes, N Hawkings, J Haworth, A Hayday, M Haynes, J Hazeldine, T Hazelton, L G Heaney, C Heeley, J L Heeney, M Heightman, S Heller, M Henderson, L Hesselden, M Hewitt, V Highett, T Hillman, T Hiwot, L-P Ho, A Hoare, M Hoare, J Hockridge, P Hogarth, A Holbourn, S Holden, L Holdsworth, D Holgate, M Holland, L Holloway, K Holmes, M Holmes, B Holroyd-Hind, L Holt, A Hormis, A Hosseini, M Hotopf, K Howard, A Howell, E Hufton, A D Hughes, J Hughes, R Hughes, A Humphries, N Huneke, E Hurditch, J Hurst, M Husain, T Hussell, J Hutchinson, W Ibrahim, F Ilyas, J Ingham, L Ingram, D Ionita, K Isaacs, K Ismail, T Jackson, J Jacob, W Y James, W Jang, C Jarman, I Jarrold, H Jarvis, R Jastrub, B Jayaraman, R G Jenkins, P Jezzard, K Jiwa, C Johnson, S Johnson, D Johnston, D Jones, G Jones, H Jones, I Jones, L Jones, M G Jones, S Jones, S Jose, T Kabir, G Kaltsakas, V Kamwa, N Kanellakis, S Kaprowska, Z Kausar, N Keenan, S Kelly, G Kemp, S Kerr, H Kerslake, A L Key, F Khan, K Khunti, S Kilroy, B King, C King, L Kingham, J Kirk, P Kitterick, P Klenerman, L Knibbs, S Knight, A Knighton, O Kon, S Kon, S S Kon, S Koprowska, A Korszun, I Koychev, C Kurasz, P Kurupati, C Laing, H Lamlum, G Landers, C Langenberg, D Lasserson, L Lavelle-Langham, A Lawrie, C Lawson, A Layton, A Lea, D Lee, J-H Lee, E Lee, K Leitch, R Lenagh, D Lewis, J Lewis, V Lewis, N Lewis-Burke, X Li, T Light, L Lightstone, W Lilaonitkul, L Lim, S Linford, A Lingford-Hughes, M Lipman, K Liyanage, A Lloyd, S Logan, D Lomas, R Loosley, J M Lord, H Lota, W Lovegrove, A Lucey, E Lukaschuk, A Lye, C Lynch, S MacDonald, G MacGowan, I Macharia, J Mackie, L Macliver, S Madathil, G Madzamba, N Magee, M M Magtoto, N Mairs, N Majeed, E Major, F Malein, M Malim, G Mallison, S Mandal, K Mangion, C Manisty, R Manley, K March, S Marciniak, P Marino, M Mariveles, E Marouzet, S Marsh, B Marshall, M Marshall, J Martin, A Martineau, L M Martinez, N Maskell, D Matila, W Matimba-Mupaya, L Matthews, A Mbuyisa, S McAdoo, H McAllister-Williams, A McArdle, P McArdle, D McAulay, G P McCann, J McCormick, W McCormick, P McCourt, L McGarvey, C McGhee, K Mcgee, J McGinness, K McGlynn, A McGovern, H McGuinness, I B McInnes, J McIntosh, E McIvor, K McIvor, L McLeavey, A McMahon, M J McMahon, L McMorrow, T Mcnally, M McNarry, J McNeill, A McQueen, H McShane, C Mears, C Megson, S Megson, P Mehta, J Meiring, L Melling, M Mencias, D Menzies, M Merida Morillas, A Michael, C Miller, L Milligan, C Mills, G Mills, N L Mills, L Milner, S Misra, J Mitchell, A Mohamed, N Mohamed, S Mohammed, W Monteiro, S Moriera, A Morley, L Morrison, R Morriss, A Morrow, A J Moss, P Moss, K Motohashi, N Msimanga, E Mukaetova-Ladinska, U Munawar, J Murira, U Nanda, H Nassa, M Nasseri, A Neal, R Needham, P Neill, S Neubauer, D E Newby, H Newell, T Newman, J Newman, A Newton-Cox, T Nicholson, D Nicoll, A Nikolaidis, C M Nolan, M J Noonan, C Norman, P Novotny, J Nunag, L Nwafor, U Nwanguma, J Nyaboko, C O'Brien, K O'Donnell, D O'Regan, L O'Brien, N Odell, G Ogg, O Olaosebikan, C Oliver, Z Omar, P J M Openshaw, L Orriss-Dib, L Osborne, R Osbourne, M Ostermann, C Overton, J Owen, J Oxton, J Pack, E Pacpaco, S Paddick, S Painter, A Pakzad, S Palmer, P Papineni, K Paques, K Paradowski, M Pareek, D Parekh, H Parfrey, C Pariante, S Parker, M Parkes, J Parmar, S Patale, M Patel, S Patel, D Pattenadk, M Pavlides, S Payne, L Pearce, J E Pearl, D Peckham, J Pendlebury, Y Peng, C Pennington, I Peralta, E Perkins, Z Peterkin, T Peto, N Petousi, J Petrie, P Pfeffer, J Phipps, J Pimm, R Pius, H Plant, S Plein, M Plowright, O Polgar, L Poll, J Porter, S Portukhay, N Powell, A Prabhu, J Pratt, A Price, C Price, D Price, L Price, A Prickett, J Propescu, S Prosper, S Pugmire, S Quaid, J Quigley, J Quint, H Qureshi, I N Qureshi, K Radhakrishnan, N M Rahman, M Ralser, A Ramos, H Ramos, J Rangeley, B Rangelov, L Ratcliffe, P Ravencroft, A Reddington, R Reddy, A Reddy, H Redfearn, D Redwood, A Reed, M Rees, T Rees, K Regan, W Reynolds, C Ribeiro, A Richards, E Richardson, K Roberts, E Robertson, E Robinson, L Robinson, L Roche, C Roddis, J Rodger, A Ross, G Ross, J Rossdale, A Rostron, A Rowe, A Rowland, J Rowland, M J Rowland, S L Rowland-Jones, K Roy, M Roy, I Rudan, R Russell, E Russell, G Saalmink, R Sabit, E K Sage, T Samakomva, N Samani, C Sampson, K Samuel, R Samuel, A Sanderson, E Sapey, D Saralaya, J Sargent, C Sarginson, T Sass, N Sattar, K Saunders, P Saunders, L C Saunders, H Savill, W Saxon, A Sayer, J Schronce, W Schwaeble, K Scott, N Selby, M G Semple, T A Sewell, K Shah, P Shah, M Shankar-Hari, M Sharma, C Sharpe, M Sharpe, S Shashaa, A Shaw, K Shaw, V Shaw, A Sheikh, S Shelton, L Shenton, K Shevket, J Short, S Siddique, S Siddiqui, J Sidebottom, L Sigfrid, G Simons, J Simpson, N Simpson, C Singh, S J Singh, D Sissons, J Skeemer, K Slack, A Smith, D Smith, S Smith, J Smith, L Smith, M Soares, T S Solano, R Solly, A R Solstice, T Soulsby, D Southern, D Sowter, M Spears, L G Spencer, F Speranza, L Stadon, S Stanel, N Steele, M Steiner, D Stensel, G Stephens, L Stephenson, M Stern, R Stimpson, S Stockdale, J Stockley, W Stoker, R Stone, W Storrar, A Storrie, K Storton, E Stringer, S Strong-Sheldrake, N Stroud, C Subbe, C L Sudlow, Z Suleiman, C Summers, C Summersgill, D Sutherland, D L Sykes, R Sykes, N Talbot, A L Tan, L Tarusan, V Tavoukjian, A Taylor, C Taylor, J Taylor, A Te, H Tedd, C J Tee, J Teixeira, H Tench, S Terry, S Thackray-Nocera, F Thaivalappil, B Thamu, D Thickett, C Thomas, D C Thomas, S Thomas, A K Thomas, T Thomas-Woods, T Thompson, A A R Thompson, T Thornton, R S Thwaites, J Tilley, N Tinker, G F Tiongson, M Tobin, J Tomlinson, C Tong, M Toshner, R Touyz, K A Tripp, E Tunnicliffe, A Turnbull, E Turner, S Turner, V Turner, K Turner, S Turney, L Turtle, H Turton, J Ugoji, R Ugwuoke, R Upthegrove, J Valabhji, M Ventura, J Vere, C Vickers, B Vinson, E Wade, P Wade, T Wainwright, L O Wajero, S Walder, S Walker, E Wall, T Wallis, S Walmsley, J A Walsh, S Walsh, L Warburton, T J C Ward, K Warwick, H Wassall, S Waterson, E Watson, L Watson, J Watson, J Weir McCall, C Welch, H Welch, B Welsh, S Wessely, S West, H Weston, H Wheeler, S White, V Whitehead, J Whitney, S Whittaker, B Whittam, V Whitworth, A Wight, J M Wild, M Wilkins, D Wilkinson, B Williams, N Williams, J Williams, S A Williams-Howard, M Willicombe, G Willis, J Willoughby, A Wilson, D Wilson, I Wilson, N Window, M Witham, R Wolf-Roberts, C Wood, F Woodhead, J Woods, J Wormleighton, J Worsley, D Wraith, C Wrey Brown, C Wright, L Wright, S Wright, J Wyles, I Wynter, M Xu, N Yasmin, S Yasmin, K P Yip, B Young, S Young, A Young, A J Yousuf, A Zawia, L Zeidan, B Zhao, B Zheng, O Zongo

The Lancet Respiratory Medicine

Swansea University Authors: Keir Lewis Orcid Logo, Melitta McNarry Orcid Logo

Abstract

Background Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. Therefore, we investigated the prevalence and nature of sleep disturbance after...

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Published in: The Lancet Respiratory Medicine
ISSN: 2213-2600
Published: Elsevier BV 2023
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa63255
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>63255</id><entry>2023-04-26</entry><title>Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study</title><swanseaauthors><author><sid>bc53c343c975d6e0ad88c1d8b9ddd70c</sid><ORCID>0000-0002-8248-6774</ORCID><firstname>Keir</firstname><surname>Lewis</surname><name>Keir Lewis</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-04-26</date><deptcode>BMS</deptcode><abstract>Background Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. Therefore, we investigated the prevalence and nature of sleep disturbance after COVID-19 hospitalisation and whether this was associated with dyspnoea. MethodsSleep parameters were assessed in a prospective multi-centre cohort of patients (n=2,468) hospitalised for COVID-19 in the United Kingdom using both subjective (n=638) and device-based (n=729) measures. Results were compared to a matched UK Biobank cohort. Multivariable linear regression was used to define associations. FindingsThe majority (62% (396/638)) of participants reported poor sleep quality. A comparable proportion (53% (338/638)) felt their sleep quality had deteriorated for at least 1-year following hospitalisation. Compared to a non-hospitalised matched cohort, both sleep regularity (44·5 vs 56·5) and sleep efficiency (85·4% vs 89·0%) were lower as opposed to sleep period duration which was longer (8·25h vs 7·17h). Overall sleep quality (effect estimate 3·9, 95%CI (2·8–5·1)), deterioration in sleep quality following hospitalisation (effect estimate 3·0, 95%CI (1·8–4·3)), and sleep regularity (effect estimate 4·4, 95%CI (2·1–6·7)) were associated with dyspnoea and impaired lung function (FEV1 and FVC). Depending on the sleep metric, anxiety mediated 18–39% of the effect of sleep disturbance on dyspnoea and muscle weakness mediated 27-41% of this effect.InterpretationSleep disturbance is associated with dyspnoea, anxiety, and muscle weakness following COVID-19 hospitalisation. Targeting sleep disturbance may be beneficial in treating the post-COVID-19 condition.</abstract><type>Journal Article</type><journal>The Lancet Respiratory Medicine</journal><volume/><journalNumber/><paginationStart/><paginationEnd/><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>2213-2600</issnPrint><issnElectronic/><keywords/><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-04-01</publishedDate><doi>10.1016/s2213-2600(23)00124-8</doi><url>http://dx.doi.org/10.1016/s2213-2600(23)00124-8</url><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>CJ is funded by an Engineering and Physical Sciences Research Council (EPSRC) Mathematics Doctoral Training Partnership (EP/W523884/1). L-PH is supported in part by the Oxford NIHR Biomedical Research Centre. PLM is supported by an Action for Pulmonary Fibrosis Mike Bray Fellowship and an Asthma + Lung UK Chair in Respiratory Research. KP-H receives funding from Innovate UK (TS/T013028/1) and the UK Medical Research Council (MRC; MR/W006111/1). JCP receives funding from the NIHR University College London Hospitals Biomedical research centre and Breathing Matters charity. BR is funded by the British Heart Foundation Oxford Centre of Research Excellence (RE/18/3/34214). ABD is funded by a Wellcome fellowship (216606/Z/19/Z). AART is supported by a British Heart Foundation intermediate clinical fellowship (FS/18/13/33281). LVW is supported by the GlaxoSmithKline/Asthma + Lung UK Chair in Respiratory Research (C17-1). DGW is funded by an NIHR Advanced Fellowship (NIHR300669). RGJ is supported by a NIHR Research Professorship (RP-2017-08-ST2-014). JFB and PSC are supported by an MRC transition support fellowship (MR/T032529/1). IDS is supported by a fellowship funded by The Rayne Foundation. The work was also supported by an Asthma + Lung UK Malcolm Walleans Grant. This work was supported by the NIHR Manchester Biomedical Research Centre (grant number NIHR203308; JFB, MKR, and AH). The study was also funded by UK Research and Innovation and National Institute of Health Research (grant references: EP/V051490/1, MR/V027859/1, MR/W006111/1, and COV0319). PHOSP-COVID is jointly funded by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 grant references above.</funders><projectreference/><lastEdited>2023-05-24T15:25:58.8981036</lastEdited><Created>2023-04-26T14:45:04.4541095</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Sport and Exercise Sciences</level></path><authors><author><firstname>Callum</firstname><surname>Jackson</surname><order>1</order></author><author><firstname>Iain D</firstname><surname>Stewart</surname><order>2</order></author><author><firstname>Tatiana</firstname><surname>Plekhanova</surname><order>3</order></author><author><firstname>Peter S</firstname><surname>Cunningham</surname><order>4</order></author><author><firstname>Andrew L</firstname><surname>Hazel</surname><order>5</order></author><author><firstname>Bashar</firstname><surname>Al-Sheklly</surname><order>6</order></author><author><firstname>Raminder</firstname><surname>Aul</surname><order>7</order></author><author><firstname>Charlotte E</firstname><surname>Bolton</surname><order>8</order></author><author><firstname>Trudie</firstname><surname>Chalder</surname><order>9</order></author><author><firstname>James D</firstname><surname>Chalmers</surname><order>10</order></author><author><firstname>Nazia</firstname><surname>Chaudhuri</surname><order>11</order></author><author><firstname>Annemarie B</firstname><surname>Docherty</surname><order>12</order></author><author><firstname>Gavin</firstname><surname>Donaldson</surname><order>13</order></author><author><firstname>Charlotte L</firstname><surname>Edwardson</surname><order>14</order></author><author><firstname>Omer</firstname><surname>Elneima</surname><order>15</order></author><author><firstname>Neil J</firstname><surname>Greening</surname><order>16</order></author><author><firstname>Neil A</firstname><surname>Hanley</surname><order>17</order></author><author><firstname>Victoria C</firstname><surname>Harris</surname><order>18</order></author><author><firstname>Ewen M</firstname><surname>Harrison</surname><order>19</order></author><author><firstname>Ling-Pei</firstname><surname>Ho</surname><order>20</order></author><author><firstname>Linzy</firstname><surname>Houchen-Wolloff</surname><order>21</order></author><author><firstname>Luke S</firstname><surname>Howard</surname><order>22</order></author><author><firstname>Caroline J</firstname><surname>Jolley</surname><order>23</order></author><author><firstname>Mark G</firstname><surname>Jones</surname><order>24</order></author><author><firstname>Olivia C</firstname><surname>Leavy</surname><order>25</order></author><author><firstname>Keir</firstname><surname>Lewis</surname><orcid>0000-0002-8248-6774</orcid><order>26</order></author><author><firstname>Nazir I</firstname><surname>Lone</surname><order>27</order></author><author><firstname>Michael</firstname><surname>Marks</surname><order>28</order></author><author><firstname>Hamish J C</firstname><surname>McAuley</surname><order>29</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>30</order></author><author><firstname>Brijesh 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M</firstname><surname>Shah</surname><order>42</order></author><author><firstname>Aarti</firstname><surname>Shikotra</surname><order>43</order></author><author><firstname>Amisha</firstname><surname>Singapuri</surname><order>44</order></author><author><firstname>Stefan C</firstname><surname>Stanel</surname><order>45</order></author><author><firstname>Mathew</firstname><surname>Thorpe</surname><order>46</order></author><author><firstname>Daniel G</firstname><surname>Wootton</surname><order>47</order></author><author><firstname>Thomas</firstname><surname>Yates</surname><order>48</order></author><author><firstname>R Gisli</firstname><surname>Jenkins</surname><order>49</order></author><author><firstname>Sally J</firstname><surname>Singh</surname><order>50</order></author><author><firstname>William D-C</firstname><surname>Man</surname><order>51</order></author><author><firstname>Christopher E</firstname><surname>Brightling</surname><order>52</order></author><author><firstname>Louise 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A</firstname><surname>Davies</surname><order>324</order></author><author><firstname>K</firstname><surname>Davies</surname><order>325</order></author><author><firstname>M J</firstname><surname>Davies</surname><order>326</order></author><author><firstname>J</firstname><surname>Dawson</surname><order>327</order></author><author><firstname>E</firstname><surname>Daynes</surname><order>328</order></author><author><firstname>A 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N</firstname><surname>Diwanji</surname><order>345</order></author><author><firstname>M</firstname><surname>Dixon</surname><order>346</order></author><author><firstname>R</firstname><surname>Djukanovic</surname><order>347</order></author><author><firstname>H</firstname><surname>Dobson</surname><order>348</order></author><author><firstname>S 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I</firstname><surname>Evans</surname><order>376</order></author><author><firstname>T</firstname><surname>Evans</surname><order>377</order></author><author><firstname>C</firstname><surname>Evenden</surname><order>378</order></author><author><firstname>L</firstname><surname>Evison</surname><order>379</order></author><author><firstname>L</firstname><surname>Fabbri</surname><order>380</order></author><author><firstname>S</firstname><surname>Fairbairn</surname><order>381</order></author><author><firstname>A</firstname><surname>Fairman</surname><order>382</order></author><author><firstname>K</firstname><surname>Fallon</surname><order>383</order></author><author><firstname>D</firstname><surname>Faluyi</surname><order>384</order></author><author><firstname>C</firstname><surname>Favager</surname><order>385</order></author><author><firstname>T</firstname><surname>Fayzan</surname><order>386</order></author><author><firstname>J</firstname><surname>Featherstone</surname><order>387</order></author><author><firstname>T</firstname><surname>Felton</surname><order>388</order></author><author><firstname>J</firstname><surname>Finch</surname><order>389</order></author><author><firstname>S</firstname><surname>Finney</surname><order>390</order></author><author><firstname>J</firstname><surname>Finnigan</surname><order>391</order></author><author><firstname>L</firstname><surname>Finnigan</surname><order>392</order></author><author><firstname>H</firstname><surname>Fisher</surname><order>393</order></author><author><firstname>S</firstname><surname>Fletcher</surname><order>394</order></author><author><firstname>R</firstname><surname>Flockton</surname><order>395</order></author><author><firstname>M</firstname><surname>Flynn</surname><order>396</order></author><author><firstname>H</firstname><surname>Foot</surname><order>397</order></author><author><firstname>D</firstname><surname>Foote</surname><order>398</order></author><author><firstname>A</firstname><surname>Ford</surname><order>399</order></author><author><firstname>D</firstname><surname>Forton</surname><order>400</order></author><author><firstname>E</firstname><surname>Fraile</surname><order>401</order></author><author><firstname>C</firstname><surname>Francis</surname><order>402</order></author><author><firstname>R</firstname><surname>Francis</surname><order>403</order></author><author><firstname>S</firstname><surname>Francis</surname><order>404</order></author><author><firstname>A</firstname><surname>Frankel</surname><order>405</order></author><author><firstname>E</firstname><surname>Fraser</surname><order>406</order></author><author><firstname>R</firstname><surname>Free</surname><order>407</order></author><author><firstname>N</firstname><surname>French</surname><order>408</order></author><author><firstname>X</firstname><surname>Fu</surname><order>409</order></author><author><firstname>J</firstname><surname>Fuld</surname><order>410</order></author><author><firstname>J</firstname><surname>Furniss</surname><order>411</order></author><author><firstname>L</firstname><surname>Garner</surname><order>412</order></author><author><firstname>N</firstname><surname>Gautam</surname><order>413</order></author><author><firstname>J R</firstname><surname>Geddes</surname><order>414</order></author><author><firstname>J</firstname><surname>George</surname><order>415</order></author><author><firstname>P M</firstname><surname>George</surname><order>416</order></author><author><firstname>M</firstname><surname>Gibbons</surname><order>417</order></author><author><firstname>M</firstname><surname>Gill</surname><order>418</order></author><author><firstname>L</firstname><surname>Gilmour</surname><order>419</order></author><author><firstname>F</firstname><surname>Gleeson</surname><order>420</order></author><author><firstname>J</firstname><surname>Glossop</surname><order>421</order></author><author><firstname>S</firstname><surname>Glover</surname><order>422</order></author><author><firstname>N</firstname><surname>Goodman</surname><order>423</order></author><author><firstname>C</firstname><surname>Goodwin</surname><order>424</order></author><author><firstname>B</firstname><surname>Gooptu</surname><order>425</order></author><author><firstname>H</firstname><surname>Gordon</surname><order>426</order></author><author><firstname>T</firstname><surname>Gorsuch</surname><order>427</order></author><author><firstname>M</firstname><surname>Greatorex</surname><order>428</order></author><author><firstname>P L</firstname><surname>Greenhaff</surname><order>429</order></author><author><firstname>W</firstname><surname>Greenhalf</surname><order>430</order></author><author><firstname>A</firstname><surname>Greenhalgh</surname><order>431</order></author><author><firstname>J</firstname><surname>Greenwood</surname><order>432</order></author><author><firstname>H</firstname><surname>Gregory</surname><order>433</order></author><author><firstname>R</firstname><surname>Gregory</surname><order>434</order></author><author><firstname>D</firstname><surname>Grieve</surname><order>435</order></author><author><firstname>D</firstname><surname>Griffin</surname><order>436</order></author><author><firstname>L</firstname><surname>Griffiths</surname><order>437</order></author><author><firstname>A-M</firstname><surname>Guerdette</surname><order>438</order></author><author><firstname>B 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G</firstname><surname>Heaney</surname><order>478</order></author><author><firstname>C</firstname><surname>Heeley</surname><order>479</order></author><author><firstname>J L</firstname><surname>Heeney</surname><order>480</order></author><author><firstname>M</firstname><surname>Heightman</surname><order>481</order></author><author><firstname>S</firstname><surname>Heller</surname><order>482</order></author><author><firstname>M</firstname><surname>Henderson</surname><order>483</order></author><author><firstname>L</firstname><surname>Hesselden</surname><order>484</order></author><author><firstname>M</firstname><surname>Hewitt</surname><order>485</order></author><author><firstname>V</firstname><surname>Highett</surname><order>486</order></author><author><firstname>T</firstname><surname>Hillman</surname><order>487</order></author><author><firstname>T</firstname><surname>Hiwot</surname><order>488</order></author><author><firstname>L-P</firstname><surname>Ho</surname><order>489</order></author><author><firstname>A</firstname><surname>Hoare</surname><order>490</order></author><author><firstname>M</firstname><surname>Hoare</surname><order>491</order></author><author><firstname>J</firstname><surname>Hockridge</surname><order>492</order></author><author><firstname>P</firstname><surname>Hogarth</surname><order>493</order></author><author><firstname>A</firstname><surname>Holbourn</surname><order>494</order></author><author><firstname>S</firstname><surname>Holden</surname><order>495</order></author><author><firstname>L</firstname><surname>Holdsworth</surname><order>496</order></author><author><firstname>D</firstname><surname>Holgate</surname><order>497</order></author><author><firstname>M</firstname><surname>Holland</surname><order>498</order></author><author><firstname>L</firstname><surname>Holloway</surname><order>499</order></author><author><firstname>K</firstname><surname>Holmes</surname><order>500</order></author><author><firstname>M</firstname><surname>Holmes</surname><order>501</order></author><author><firstname>B</firstname><surname>Holroyd-Hind</surname><order>502</order></author><author><firstname>L</firstname><surname>Holt</surname><order>503</order></author><author><firstname>A</firstname><surname>Hormis</surname><order>504</order></author><author><firstname>A</firstname><surname>Hosseini</surname><order>505</order></author><author><firstname>M</firstname><surname>Hotopf</surname><order>506</order></author><author><firstname>K</firstname><surname>Howard</surname><order>507</order></author><author><firstname>A</firstname><surname>Howell</surname><order>508</order></author><author><firstname>E</firstname><surname>Hufton</surname><order>509</order></author><author><firstname>A 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spelling v2 63255 2023-04-26 Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study bc53c343c975d6e0ad88c1d8b9ddd70c 0000-0002-8248-6774 Keir Lewis Keir Lewis true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2023-04-26 BMS Background Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. Therefore, we investigated the prevalence and nature of sleep disturbance after COVID-19 hospitalisation and whether this was associated with dyspnoea. MethodsSleep parameters were assessed in a prospective multi-centre cohort of patients (n=2,468) hospitalised for COVID-19 in the United Kingdom using both subjective (n=638) and device-based (n=729) measures. Results were compared to a matched UK Biobank cohort. Multivariable linear regression was used to define associations. FindingsThe majority (62% (396/638)) of participants reported poor sleep quality. A comparable proportion (53% (338/638)) felt their sleep quality had deteriorated for at least 1-year following hospitalisation. Compared to a non-hospitalised matched cohort, both sleep regularity (44·5 vs 56·5) and sleep efficiency (85·4% vs 89·0%) were lower as opposed to sleep period duration which was longer (8·25h vs 7·17h). Overall sleep quality (effect estimate 3·9, 95%CI (2·8–5·1)), deterioration in sleep quality following hospitalisation (effect estimate 3·0, 95%CI (1·8–4·3)), and sleep regularity (effect estimate 4·4, 95%CI (2·1–6·7)) were associated with dyspnoea and impaired lung function (FEV1 and FVC). Depending on the sleep metric, anxiety mediated 18–39% of the effect of sleep disturbance on dyspnoea and muscle weakness mediated 27-41% of this effect.InterpretationSleep disturbance is associated with dyspnoea, anxiety, and muscle weakness following COVID-19 hospitalisation. Targeting sleep disturbance may be beneficial in treating the post-COVID-19 condition. Journal Article The Lancet Respiratory Medicine Elsevier BV 2213-2600 1 4 2023 2023-04-01 10.1016/s2213-2600(23)00124-8 http://dx.doi.org/10.1016/s2213-2600(23)00124-8 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University CJ is funded by an Engineering and Physical Sciences Research Council (EPSRC) Mathematics Doctoral Training Partnership (EP/W523884/1). L-PH is supported in part by the Oxford NIHR Biomedical Research Centre. PLM is supported by an Action for Pulmonary Fibrosis Mike Bray Fellowship and an Asthma + Lung UK Chair in Respiratory Research. KP-H receives funding from Innovate UK (TS/T013028/1) and the UK Medical Research Council (MRC; MR/W006111/1). JCP receives funding from the NIHR University College London Hospitals Biomedical research centre and Breathing Matters charity. BR is funded by the British Heart Foundation Oxford Centre of Research Excellence (RE/18/3/34214). ABD is funded by a Wellcome fellowship (216606/Z/19/Z). AART is supported by a British Heart Foundation intermediate clinical fellowship (FS/18/13/33281). LVW is supported by the GlaxoSmithKline/Asthma + Lung UK Chair in Respiratory Research (C17-1). DGW is funded by an NIHR Advanced Fellowship (NIHR300669). RGJ is supported by a NIHR Research Professorship (RP-2017-08-ST2-014). JFB and PSC are supported by an MRC transition support fellowship (MR/T032529/1). IDS is supported by a fellowship funded by The Rayne Foundation. The work was also supported by an Asthma + Lung UK Malcolm Walleans Grant. This work was supported by the NIHR Manchester Biomedical Research Centre (grant number NIHR203308; JFB, MKR, and AH). The study was also funded by UK Research and Innovation and National Institute of Health Research (grant references: EP/V051490/1, MR/V027859/1, MR/W006111/1, and COV0319). PHOSP-COVID is jointly funded by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 grant references above. 2023-05-24T15:25:58.8981036 2023-04-26T14:45:04.4541095 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Callum Jackson 1 Iain D Stewart 2 Tatiana Plekhanova 3 Peter S Cunningham 4 Andrew L Hazel 5 Bashar Al-Sheklly 6 Raminder Aul 7 Charlotte E Bolton 8 Trudie Chalder 9 James D Chalmers 10 Nazia Chaudhuri 11 Annemarie B Docherty 12 Gavin Donaldson 13 Charlotte L Edwardson 14 Omer Elneima 15 Neil J Greening 16 Neil A Hanley 17 Victoria C Harris 18 Ewen M Harrison 19 Ling-Pei Ho 20 Linzy Houchen-Wolloff 21 Luke S Howard 22 Caroline J Jolley 23 Mark G Jones 24 Olivia C Leavy 25 Keir Lewis 0000-0002-8248-6774 26 Nazir I Lone 27 Michael Marks 28 Hamish J C McAuley 29 Melitta McNarry 0000-0003-0813-7477 30 Brijesh V Patel 31 Karen Piper-Hanley 32 Krisnah Poinasamy 33 Betty Raman 34 Matthew Richardson 35 Pilar Rivera-Ortega 36 Sarah L Rowland-Jones 37 Alex V Rowlands 38 Ruth M Saunders 39 Janet T Scott 40 Marco Sereno 41 Ajay M Shah 42 Aarti Shikotra 43 Amisha Singapuri 44 Stefan C Stanel 45 Mathew Thorpe 46 Daniel G Wootton 47 Thomas Yates 48 R Gisli Jenkins 49 Sally J Singh 50 William D-C Man 51 Christopher E Brightling 52 Louise V Wain 53 Joanna C Porter 54 A A Roger Thompson 55 Alex Horsley 56 Philip L Molyneaux 57 Rachael A Evans 58 Samuel E Jones 59 Martin K Rutter 60 John F Blaikley 61 C Jackson 62 I D Stewart 63 T Plekhanova 64 P S Cunningham 65 A L Hazel 66 B Al-Sheklly 67 R Aul 68 C E Bolton 69 T Chalder 70 J D Chalmers 71 N Chaudhuri 72 A B Docherty 73 G Donaldson 74 C L Edwardson 75 O Elneima 76 N J Greening 77 N A Hanley 78 V C Harris 79 E M Harrison 80 L-P Ho 81 L Houchen-Wolloff 82 L S Howard 83 C J Jolley 84 M G Jones 85 O C Leavy 86 K E Lewis 87 N I Lone 88 M Marks 89 H J C McAuley 90 M A McNarry 91 B Patel 92 K Piper-Hanley 93 K Poinasamy 94 B Raman 95 M Richardson 96 P Rivera-Ortega 97 S L Rowland-Jones 98 A V Rowlands 99 R M Saunders 100 J T Scott 101 M Sereno 102 A M Shah 103 A Shikotra 104 A Singapuri 105 S C Stanel 106 M Thorpe 107 D G Wootton 108 T Yates 109 G Jenkins 110 S J Singh 111 W D-C Man 112 C E Brightling 113 L V Wain 114 J C Porter 115 R Thompson 116 A Horsley 117 P L Molyneaux 118 R A Evans 119 S E Jones 120 M K Rutter 121 J F Blaikley 122 K Abel 123 H Adamali 124 D Adeloye 125 O Adeyemi 126 R Adrego 127 L A Aguilar Jimenez 128 S Ahmad 129 N Ahmad Haider 130 R Ahmed 131 N Ahwireng 132 M Ainsworth 133 B Al-Sheklly 134 A Alamoudi 135 M Ali 136 M Aljaroof 137 AM All 138 L Allan 139 R J Allen 140 L Allerton 141 L Allsop 142 P Almeida 143 D Altmann 144 M Alvarez Corral 145 S Amoils 146 D Anderson 147 C Antoniades 148 G Arbane 149 A Arias 150 C Armour 151 L Armstrong 152 N Armstrong 153 D Arnold 154 H Arnold 155 A Ashish 156 A Ashworth 157 M Ashworth 158 S Aslani 159 H Assefa-Kebede 160 C Atkin 161 P Atkin 162 H Aung 163 L Austin 164 C Avram 165 A Ayoub 166 M Babores 167 R Baggott 168 J Bagshaw 169 D Baguley 170 L Bailey 171 J K Baillie 172 S Bain 173 M Bakali 174 M Bakau 175 E Baldry 176 D Baldwin 177 M Baldwin 178 C Ballard 179 A Banerjee 180 B Bang 181 R E Barker 182 L Barman 183 S Barratt 184 F Barrett 185 D Basire 186 N Basu 187 M Bates 188 A Bates 189 R Batterham 190 H Baxendale 191 H Bayes 192 M Beadsworth 193 P Beckett 194 M Beggs 195 M Begum 196 P Beirne 197 D Bell 198 R Bell 199 K Bennett 200 E Beranova 201 A Bermperi 202 A Berridge 203 C Berry 204 S Betts 205 E Bevan 206 K Bhui 207 M Bingham 208 K Birchall 209 L Bishop 210 K Bisnauthsing 211 J Blaikely 212 A Bloss 213 A Bolger 214 J Bonnington 215 A Botkai 216 C Bourne 217 M Bourne 218 K Bramham 219 L Brear 220 G Breen 221 J Breeze 222 A Briggs 223 E Bright 224 S Brill 225 K Brindle 226 L Broad 227 A Broadley 228 C Brookes 229 M Broome 230 A Brown 231 J Brown 232 J S Brown 233 M Brown 234 V Brown 235 T Brugha 236 N Brunskill 237 M Buch 238 P Buckley 239 A Bularga 240 E Bullmore 241 L Burden 242 T Burdett 243 D Burn 244 G Burns 245 A Burns 246 J Busby 247 R Butcher 248 A Butt 249 S Byrne 250 P Cairns 251 P C Calder 252 E Calvelo 253 H Carborn 254 B Card 255 C Carr 256 L Carr 257 G Carson 258 P Carter 259 A Casey 260 M Cassar 261 J Cavanagh 262 M Chablani 263 R C Chambers 264 F Chan 265 K M Channon 266 K Chapman 267 A Charalambou 268 A Checkley 269 J Chen 270 Y Cheng 271 L Chetham 272 C Childs 273 E R Chilvers 274 H Chinoy 275 A Chiribiri 276 K Chong-James 277 G Choudhury 278 N Choudhury 279 P Chowienczyk 280 C Christie 281 M Chrystal 282 D Clark 283 C Clark 284 J Clarke 285 S Clohisey 286 G Coakley 287 Z Coburn 288 S Coetzee 289 J Cole 290 C Coleman 291 F Conneh 292 D Connell 293 B Connolly 294 L Connor 295 A Cook 296 B Cooper 297 J Cooper 298 S Cooper 299 D Copeland 300 T Cosier 301 M Coulding 302 C Coupland 303 E Cox 304 T Craig 305 P Crisp 306 D Cristiano 307 M G Crooks 308 A Cross 309 I Cruz 310 P Cullinan 311 D Cuthbertson 312 L Daines 313 M Dalton 314 P Daly 315 A Daniels 316 P Dark 317 J Dasgin 318 A David 319 C David 320 E Davies 321 F Davies 322 G Davies 323 G A Davies 324 K Davies 325 M J Davies 326 J Dawson 327 E Daynes 328 A De Soyza 329 B Deakin 330 A Deans 331 C Deas 332 J Deery 333 S Defres 334 A Dell 335 K Dempsey 336 E Denneny 337 J Dennis 338 A Dewar 339 R Dharmagunawardena 340 N Diar-Bakerly 341 C Dickens 342 A Dipper 343 S Diver 344 S N Diwanji 345 M Dixon 346 R Djukanovic 347 H Dobson 348 S L Dobson 349 A Donaldson 350 T Dong 351 N Dormand 352 A Dougherty 353 R Dowling 354 S Drain 355 K Draxlbauer 356 K Drury 357 P Dulawan 358 A Dunleavy 359 S Dunn 360 C Dupont 361 J Earley 362 N Easom 363 C Echevarria 364 S Edwards 365 C Edwardson 366 H El-Taweel 367 A Elliott 368 K Elliott 369 Y Ellis 370 A Elmer 371 D Evans 372 H Evans 373 J Evans 374 R Evans 375 R I Evans 376 T 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title Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
spellingShingle Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Keir Lewis
Melitta McNarry
title_short Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
title_full Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
title_fullStr Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
title_full_unstemmed Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
title_sort Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
author_id_str_mv bc53c343c975d6e0ad88c1d8b9ddd70c
062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv bc53c343c975d6e0ad88c1d8b9ddd70c_***_Keir Lewis
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
author Keir Lewis
Melitta McNarry
author2 Callum Jackson
Iain D Stewart
Tatiana Plekhanova
Peter S Cunningham
Andrew L Hazel
Bashar Al-Sheklly
Raminder Aul
Charlotte E Bolton
Trudie Chalder
James D Chalmers
Nazia Chaudhuri
Annemarie B Docherty
Gavin Donaldson
Charlotte L Edwardson
Omer Elneima
Neil J Greening
Neil A Hanley
Victoria C Harris
Ewen M Harrison
Ling-Pei Ho
Linzy Houchen-Wolloff
Luke S Howard
Caroline J Jolley
Mark G Jones
Olivia C Leavy
Keir Lewis
Nazir I Lone
Michael Marks
Hamish J C McAuley
Melitta McNarry
Brijesh V Patel
Karen Piper-Hanley
Krisnah Poinasamy
Betty Raman
Matthew Richardson
Pilar Rivera-Ortega
Sarah L Rowland-Jones
Alex V Rowlands
Ruth M Saunders
Janet T Scott
Marco Sereno
Ajay M Shah
Aarti Shikotra
Amisha Singapuri
Stefan C Stanel
Mathew Thorpe
Daniel G Wootton
Thomas Yates
R Gisli Jenkins
Sally J Singh
William D-C Man
Christopher E Brightling
Louise V Wain
Joanna C Porter
A A Roger Thompson
Alex Horsley
Philip L Molyneaux
Rachael A Evans
Samuel E Jones
Martin K Rutter
John F Blaikley
C Jackson
I D Stewart
T Plekhanova
P S Cunningham
A L Hazel
B Al-Sheklly
R Aul
C E Bolton
T Chalder
J D Chalmers
N Chaudhuri
A B Docherty
G Donaldson
C L Edwardson
O Elneima
N J Greening
N A Hanley
V C Harris
E M Harrison
L-P Ho
L Houchen-Wolloff
L S Howard
C J Jolley
M G Jones
O C Leavy
K E Lewis
N I Lone
M Marks
H J C McAuley
M A McNarry
B Patel
K Piper-Hanley
K Poinasamy
B Raman
M Richardson
P Rivera-Ortega
S L Rowland-Jones
A V Rowlands
R M Saunders
J T Scott
M Sereno
A M Shah
A Shikotra
A Singapuri
S C Stanel
M Thorpe
D G Wootton
T Yates
G Jenkins
S J Singh
W D-C Man
C E Brightling
L V Wain
J C Porter
R Thompson
A Horsley
P L Molyneaux
R A Evans
S E Jones
M K Rutter
J F Blaikley
K Abel
H Adamali
D Adeloye
O Adeyemi
R Adrego
L A Aguilar Jimenez
S Ahmad
N Ahmad Haider
R Ahmed
N Ahwireng
M Ainsworth
B Al-Sheklly
A Alamoudi
M Ali
M Aljaroof
AM All
L Allan
R J Allen
L Allerton
L Allsop
P Almeida
D Altmann
M Alvarez Corral
S Amoils
D Anderson
C Antoniades
G Arbane
A Arias
C Armour
L Armstrong
N Armstrong
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H Arnold
A Ashish
A Ashworth
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P Atkin
H Aung
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C Avram
A Ayoub
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format Journal article
container_title The Lancet Respiratory Medicine
publishDate 2023
institution Swansea University
issn 2213-2600
doi_str_mv 10.1016/s2213-2600(23)00124-8
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
url http://dx.doi.org/10.1016/s2213-2600(23)00124-8
document_store_str 1
active_str 0
description Background Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. Therefore, we investigated the prevalence and nature of sleep disturbance after COVID-19 hospitalisation and whether this was associated with dyspnoea. MethodsSleep parameters were assessed in a prospective multi-centre cohort of patients (n=2,468) hospitalised for COVID-19 in the United Kingdom using both subjective (n=638) and device-based (n=729) measures. Results were compared to a matched UK Biobank cohort. Multivariable linear regression was used to define associations. FindingsThe majority (62% (396/638)) of participants reported poor sleep quality. A comparable proportion (53% (338/638)) felt their sleep quality had deteriorated for at least 1-year following hospitalisation. Compared to a non-hospitalised matched cohort, both sleep regularity (44·5 vs 56·5) and sleep efficiency (85·4% vs 89·0%) were lower as opposed to sleep period duration which was longer (8·25h vs 7·17h). Overall sleep quality (effect estimate 3·9, 95%CI (2·8–5·1)), deterioration in sleep quality following hospitalisation (effect estimate 3·0, 95%CI (1·8–4·3)), and sleep regularity (effect estimate 4·4, 95%CI (2·1–6·7)) were associated with dyspnoea and impaired lung function (FEV1 and FVC). Depending on the sleep metric, anxiety mediated 18–39% of the effect of sleep disturbance on dyspnoea and muscle weakness mediated 27-41% of this effect.InterpretationSleep disturbance is associated with dyspnoea, anxiety, and muscle weakness following COVID-19 hospitalisation. Targeting sleep disturbance may be beneficial in treating the post-COVID-19 condition.
published_date 2023-04-01T15:26:00Z
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