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Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives

Thabang B. M. Mosaka, John O. Unuofin, Michael O. Daramola, Chedly Tizaoui Orcid Logo, Samuel A. Iwarere

Frontiers in Microbiology, Volume: 13

Swansea University Author: Chedly Tizaoui Orcid Logo

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DOI (Published version): 10.3389/fmicb.2022.1100102

Abstract

The discovery of antibiotics, which was once regarded as a timely medical intervention now leaves a bitter aftertaste: antimicrobial resistance (AMR), due to the unregulated use of these compounds and the poor management receiving wastewaters before discharge into pristine environments or the recycl...

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Published in: Frontiers in Microbiology
ISSN: 1664-302X
Published: Frontiers Media SA
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Wastewater treatment plants (WWTPs) have been regarded a central sink for the mostly unmetabolized or partially metabolised antibiotics and is also pivotal tothe incidence of antibiotic resistance bacteria (ARBs) and their resistance genes (ARGs), which consistently contribute to the global disease burden and deteriorating prophylaxis. In this regard, we highlighted WWTP-antibiotics consumption-ARBs-ARGs nexus, which might be critical to understanding the epidemiology of AMR and also guide the precise prevention and remediation of such occurrences. We also discovered the unsophistication of conventional WWTPs and treatment techniques for adequate treatment of antibiotics, ARBs and ARGs, due to their lack of compliancewith environmental sustainability, then ultimately assessed the prospects of cold atmospheric plasma (CAP). Herein, we observed that CAP technologies not only has the capability to disinfect wastewater polluted with copious amounts of chemicals and biologicals, but also have a potential to augment bioelectricity generation, when integrated into bio electrochemical modules, which future WWTPs should be retrofitted to accommodate. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling v2 63281 2023-04-28 Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives 4b34a0286d3c0b0b081518fa6987031d 0000-0003-2159-7881 Chedly Tizaoui Chedly Tizaoui true false 2023-04-28 CHEG The discovery of antibiotics, which was once regarded as a timely medical intervention now leaves a bitter aftertaste: antimicrobial resistance (AMR), due to the unregulated use of these compounds and the poor management receiving wastewaters before discharge into pristine environments or the recycling of such treated waters. Wastewater treatment plants (WWTPs) have been regarded a central sink for the mostly unmetabolized or partially metabolised antibiotics and is also pivotal tothe incidence of antibiotic resistance bacteria (ARBs) and their resistance genes (ARGs), which consistently contribute to the global disease burden and deteriorating prophylaxis. In this regard, we highlighted WWTP-antibiotics consumption-ARBs-ARGs nexus, which might be critical to understanding the epidemiology of AMR and also guide the precise prevention and remediation of such occurrences. We also discovered the unsophistication of conventional WWTPs and treatment techniques for adequate treatment of antibiotics, ARBs and ARGs, due to their lack of compliancewith environmental sustainability, then ultimately assessed the prospects of cold atmospheric plasma (CAP). Herein, we observed that CAP technologies not only has the capability to disinfect wastewater polluted with copious amounts of chemicals and biologicals, but also have a potential to augment bioelectricity generation, when integrated into bio electrochemical modules, which future WWTPs should be retrofitted to accommodate. Therefore, further research should be conducted to unveil more of the unknowns, which only a snippet has been highlighted in this study. Journal Article Frontiers in Microbiology 13 Frontiers Media SA 1664-302X antibiotic-resistant bacteria, antibiotic-resistance genes, wastewater, disinfection method, cold atmospheric plasma 0 0 0 0001-01-01 10.3389/fmicb.2022.1100102 http://dx.doi.org/10.3389/fmicb.2022.1100102 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University This work was supported by the Government of the United Kingdom under the Global Challenge Research Funds through the Royal Society in which the corresponding author SI is a FLAIR Fellow [FLR\R1\201683]. JU was supported by the National Research Foundation of South Africa [Grant no: 138445]. 2023-06-05T09:17:06.2662454 2023-04-28T15:49:49.7233709 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Thabang B. M. Mosaka 1 John O. Unuofin 2 Michael O. Daramola 3 Chedly Tizaoui 0000-0003-2159-7881 4 Samuel A. Iwarere 5 63281__27275__822bc39a442d4efcbf9bebcc616f0c20.pdf 63281.pdf 2023-04-28T15:54:19.6643536 Output 1417433 application/pdf Version of Record true © 2023 Mosaka, Unuofin, Daramola, Tizaoui and Iwarere. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. true eng http://creativecommons.org/licenses/by/4.0/
title Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
spellingShingle Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
Chedly Tizaoui
title_short Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
title_full Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
title_fullStr Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
title_full_unstemmed Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
title_sort Inactivation of antibiotic-resistant bacteria and antibiotic-resistance genes in wastewater streams: Current challenges and future perspectives
author_id_str_mv 4b34a0286d3c0b0b081518fa6987031d
author_id_fullname_str_mv 4b34a0286d3c0b0b081518fa6987031d_***_Chedly Tizaoui
author Chedly Tizaoui
author2 Thabang B. M. Mosaka
John O. Unuofin
Michael O. Daramola
Chedly Tizaoui
Samuel A. Iwarere
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container_title Frontiers in Microbiology
container_volume 13
institution Swansea University
issn 1664-302X
doi_str_mv 10.3389/fmicb.2022.1100102
publisher Frontiers Media SA
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hierarchy_top_title Faculty of Science and Engineering
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department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
url http://dx.doi.org/10.3389/fmicb.2022.1100102
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description The discovery of antibiotics, which was once regarded as a timely medical intervention now leaves a bitter aftertaste: antimicrobial resistance (AMR), due to the unregulated use of these compounds and the poor management receiving wastewaters before discharge into pristine environments or the recycling of such treated waters. Wastewater treatment plants (WWTPs) have been regarded a central sink for the mostly unmetabolized or partially metabolised antibiotics and is also pivotal tothe incidence of antibiotic resistance bacteria (ARBs) and their resistance genes (ARGs), which consistently contribute to the global disease burden and deteriorating prophylaxis. In this regard, we highlighted WWTP-antibiotics consumption-ARBs-ARGs nexus, which might be critical to understanding the epidemiology of AMR and also guide the precise prevention and remediation of such occurrences. We also discovered the unsophistication of conventional WWTPs and treatment techniques for adequate treatment of antibiotics, ARBs and ARGs, due to their lack of compliancewith environmental sustainability, then ultimately assessed the prospects of cold atmospheric plasma (CAP). Herein, we observed that CAP technologies not only has the capability to disinfect wastewater polluted with copious amounts of chemicals and biologicals, but also have a potential to augment bioelectricity generation, when integrated into bio electrochemical modules, which future WWTPs should be retrofitted to accommodate. Therefore, further research should be conducted to unveil more of the unknowns, which only a snippet has been highlighted in this study.
published_date 0001-01-01T09:17:05Z
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