Journal article 405 views 59 downloads
Microneedle technology for potential SARS-CoV-2 vaccine delivery
Expert Opinion on Drug Delivery, Pages: 1 - 16
Swansea University Authors:
Megan McNamee, Shuyi Wong, Owen Guy , Sanjiv Sharma
-
PDF | Version of Record
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
Download (2.44MB)
DOI (Published version): 10.1080/17425247.2023.2209718
Abstract
IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vac...
Published in: | Expert Opinion on Drug Delivery |
---|---|
ISSN: | 1742-5247 1744-7593 |
Published: |
Informa UK Limited
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa63375 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2023-05-09T13:27:06Z |
---|---|
last_indexed |
2023-05-09T13:27:06Z |
id |
cronfa63375 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>63375</id><entry>2023-05-09</entry><title>Microneedle technology for potential SARS-CoV-2 vaccine delivery</title><swanseaauthors><author><sid>c3f02aa2478f79f98cd969fbd002dc59</sid><firstname>Megan</firstname><surname>McNamee</surname><name>Megan McNamee</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>a9270e65fde82c8d0ea713a408feb44d</sid><firstname>Shuyi</firstname><surname>Wong</surname><name>Shuyi Wong</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>c7fa5949b8528e048c5b978005f66794</sid><ORCID>0000-0002-6449-4033</ORCID><firstname>Owen</firstname><surname>Guy</surname><name>Owen Guy</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>b6b7506358522f607b171ec9c94757b7</sid><ORCID>0000-0003-3828-737X</ORCID><firstname>Sanjiv</firstname><surname>Sharma</surname><name>Sanjiv Sharma</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-05-09</date><deptcode>OICWS</deptcode><abstract>IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vaccine delivery. Microneedle arrays have been fabricated in different shapes, geometries, formats, and out of different materials.Areas coveredThe recent pandemic has offered microneedle platforms the opportunity to be employed as a vehicle for SARS-CoV-2 vaccine administration. Various modes of vaccination delivery and the potential of microneedle array-based vaccines will be presented, with a specific focus placed on recent SARS-CoV-2 research. The advantages of microneedle-based vaccine administration, in addition to the major hurdles to their en masse implementation, will be examined.Expert opinionConsidering the widely acknowledged disadvantages of current vaccine delivery, such as anxiety, pain, and the requirement for professional administration, a large shift in this research sphere is imminent. The SARS-CoV-2 pandemic has catalyzed the development of alternate vaccination platforms, working to avoid the requirement for mass vaccination centers. As microneedle vaccine patches are transitioning through clinical study phases, research will be required to prepare this technology for a more mass production environment.</abstract><type>Journal Article</type><journal>Expert Opinion on Drug Delivery</journal><volume/><journalNumber/><paginationStart>1</paginationStart><paginationEnd>16</paginationEnd><publisher>Informa UK Limited</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1742-5247</issnPrint><issnElectronic>1744-7593</issnElectronic><keywords>Microneedles, skin, vaccine, pain-free, minimally invasive, SARS-CoV-2, vaccination, vaccine patch, theranostics</keywords><publishedDay>0</publishedDay><publishedMonth>0</publishedMonth><publishedYear>0</publishedYear><publishedDate>0001-01-01</publishedDate><doi>10.1080/17425247.2023.2209718</doi><url>http://dx.doi.org/10.1080/17425247.2023.2209718</url><notes/><college>COLLEGE NANME</college><department>The College, Swansea University</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>OICWS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>Swansea University</funders><projectreference/><lastEdited>2023-06-21T10:03:59.4187740</lastEdited><Created>2023-05-09T14:24:47.6315946</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Megan</firstname><surname>McNamee</surname><order>1</order></author><author><firstname>Shuyi</firstname><surname>Wong</surname><order>2</order></author><author><firstname>Owen</firstname><surname>Guy</surname><orcid>0000-0002-6449-4033</orcid><order>3</order></author><author><firstname>Sanjiv</firstname><surname>Sharma</surname><orcid>0000-0003-3828-737X</orcid><order>4</order></author></authors><documents><document><filename>63375__27771__dcaeaa0f4a5e4652a2e436bdbf8acf40.pdf</filename><originalFilename>63375.pdf</originalFilename><uploaded>2023-06-08T15:48:50.2543691</uploaded><type>Output</type><contentLength>2560474</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
spelling |
v2 63375 2023-05-09 Microneedle technology for potential SARS-CoV-2 vaccine delivery c3f02aa2478f79f98cd969fbd002dc59 Megan McNamee Megan McNamee true false a9270e65fde82c8d0ea713a408feb44d Shuyi Wong Shuyi Wong true false c7fa5949b8528e048c5b978005f66794 0000-0002-6449-4033 Owen Guy Owen Guy true false b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2023-05-09 OICWS IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vaccine delivery. Microneedle arrays have been fabricated in different shapes, geometries, formats, and out of different materials.Areas coveredThe recent pandemic has offered microneedle platforms the opportunity to be employed as a vehicle for SARS-CoV-2 vaccine administration. Various modes of vaccination delivery and the potential of microneedle array-based vaccines will be presented, with a specific focus placed on recent SARS-CoV-2 research. The advantages of microneedle-based vaccine administration, in addition to the major hurdles to their en masse implementation, will be examined.Expert opinionConsidering the widely acknowledged disadvantages of current vaccine delivery, such as anxiety, pain, and the requirement for professional administration, a large shift in this research sphere is imminent. The SARS-CoV-2 pandemic has catalyzed the development of alternate vaccination platforms, working to avoid the requirement for mass vaccination centers. As microneedle vaccine patches are transitioning through clinical study phases, research will be required to prepare this technology for a more mass production environment. Journal Article Expert Opinion on Drug Delivery 1 16 Informa UK Limited 1742-5247 1744-7593 Microneedles, skin, vaccine, pain-free, minimally invasive, SARS-CoV-2, vaccination, vaccine patch, theranostics 0 0 0 0001-01-01 10.1080/17425247.2023.2209718 http://dx.doi.org/10.1080/17425247.2023.2209718 COLLEGE NANME The College, Swansea University COLLEGE CODE OICWS Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University 2023-06-21T10:03:59.4187740 2023-05-09T14:24:47.6315946 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Megan McNamee 1 Shuyi Wong 2 Owen Guy 0000-0002-6449-4033 3 Sanjiv Sharma 0000-0003-3828-737X 4 63375__27771__dcaeaa0f4a5e4652a2e436bdbf8acf40.pdf 63375.pdf 2023-06-08T15:48:50.2543691 Output 2560474 application/pdf Version of Record true © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/ |
title |
Microneedle technology for potential SARS-CoV-2 vaccine delivery |
spellingShingle |
Microneedle technology for potential SARS-CoV-2 vaccine delivery Megan McNamee Shuyi Wong Owen Guy Sanjiv Sharma |
title_short |
Microneedle technology for potential SARS-CoV-2 vaccine delivery |
title_full |
Microneedle technology for potential SARS-CoV-2 vaccine delivery |
title_fullStr |
Microneedle technology for potential SARS-CoV-2 vaccine delivery |
title_full_unstemmed |
Microneedle technology for potential SARS-CoV-2 vaccine delivery |
title_sort |
Microneedle technology for potential SARS-CoV-2 vaccine delivery |
author_id_str_mv |
c3f02aa2478f79f98cd969fbd002dc59 a9270e65fde82c8d0ea713a408feb44d c7fa5949b8528e048c5b978005f66794 b6b7506358522f607b171ec9c94757b7 |
author_id_fullname_str_mv |
c3f02aa2478f79f98cd969fbd002dc59_***_Megan McNamee a9270e65fde82c8d0ea713a408feb44d_***_Shuyi Wong c7fa5949b8528e048c5b978005f66794_***_Owen Guy b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma |
author |
Megan McNamee Shuyi Wong Owen Guy Sanjiv Sharma |
author2 |
Megan McNamee Shuyi Wong Owen Guy Sanjiv Sharma |
format |
Journal article |
container_title |
Expert Opinion on Drug Delivery |
container_start_page |
1 |
institution |
Swansea University |
issn |
1742-5247 1744-7593 |
doi_str_mv |
10.1080/17425247.2023.2209718 |
publisher |
Informa UK Limited |
college_str |
Faculty of Science and Engineering |
hierarchytype |
|
hierarchy_top_id |
facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
hierarchy_parent_id |
facultyofscienceandengineering |
hierarchy_parent_title |
Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering |
url |
http://dx.doi.org/10.1080/17425247.2023.2209718 |
document_store_str |
1 |
active_str |
0 |
description |
IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vaccine delivery. Microneedle arrays have been fabricated in different shapes, geometries, formats, and out of different materials.Areas coveredThe recent pandemic has offered microneedle platforms the opportunity to be employed as a vehicle for SARS-CoV-2 vaccine administration. Various modes of vaccination delivery and the potential of microneedle array-based vaccines will be presented, with a specific focus placed on recent SARS-CoV-2 research. The advantages of microneedle-based vaccine administration, in addition to the major hurdles to their en masse implementation, will be examined.Expert opinionConsidering the widely acknowledged disadvantages of current vaccine delivery, such as anxiety, pain, and the requirement for professional administration, a large shift in this research sphere is imminent. The SARS-CoV-2 pandemic has catalyzed the development of alternate vaccination platforms, working to avoid the requirement for mass vaccination centers. As microneedle vaccine patches are transitioning through clinical study phases, research will be required to prepare this technology for a more mass production environment. |
published_date |
0001-01-01T10:03:58Z |
_version_ |
1769302380468240384 |
score |
11.021648 |