Journal article 224 views 56 downloads
A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
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Abel J. Duarte ,
Sanjiv Sharma ,
Felismina T. C. Moreira
Sensors & Diagnostics
Swansea University Authors:
Georgeta Vulpe, Sanjiv Sharma
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DOI (Published version): 10.1039/d3sd00022b
Abstract
Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based Po...
| Published in: | Sensors & Diagnostics |
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| ISSN: | 2635-0998 |
| Published: |
Royal Society of Chemistry (RSC)
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa63391 |
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| Abstract: |
Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based PoCT device. Cork is known to be fully biodegradable and easily recycled without producing toxic residues. We report on how cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an "artificial antibody" can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg/mL, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. In addition, it has a huge environmental impact as it can reduce the waste generated by other polymeric/ceramic carriers used for the same purpose. |
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| College: |
Faculty of Science and Engineering |
| Funders: |
The authors acknowledge funding through project 2IQBioneuro with the reference (0624_2IQBIONEURO_6_E), entitled, Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases, EP-INTERREG V Spain Portugal (POCTEP). Daniela O. acknowledge funding from Fundação para a Ciência e Tecnologia, I.P., through the PhD grant reference SFRH/BD/137832/2018. This work was also supported by Multi-year funding of European Union (FEDER funds through Compete) and National Funds (FCT/MCTES) through Project UID/QUI/50006/2019 and UIDB/04730/2020. |