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A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers

Bárbara Correia, Daniela Oliveira, Georgeta Vulpe, Ana P. M. Tavares, M. Goreti F. Sales Orcid Logo, Abel J. Duarte Orcid Logo, Sanjiv Sharma Orcid Logo, Felismina T. C. Moreira, Georgeta Vulpe

Sensors & Diagnostics, Volume: 2, Issue: 4, Pages: 956 - 963

Swansea University Authors: Sanjiv Sharma Orcid Logo, Georgeta Vulpe

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DOI (Published version): 10.1039/d3sd00022b

Abstract

Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based Po...

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Published in: Sensors & Diagnostics
ISSN: 2635-0998
Published: Royal Society of Chemistry (RSC) 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa63391
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These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based PoCT device. Cork is known to be fully biodegradable and easily recycled without producing toxic residues. We report on how cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an "artificial antibody" can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg/mL, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. 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Daniela O. acknowledge funding from Fundação para a Ciência e Tecnologia, I.P., through the PhD grant reference SFRH/BD/137832/2018. This work was also supported by Multi-year funding of European Union (FEDER funds through Compete) and National Funds (FCT/MCTES) through Project UID/QUI/50006/2019 and UIDB/04730/2020.</funders><projectreference/><lastEdited>2024-09-26T15:46:27.1178288</lastEdited><Created>2023-05-10T14:18:35.3894177</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Bárbara</firstname><surname>Correia</surname><order>1</order></author><author><firstname>Daniela</firstname><surname>Oliveira</surname><order>2</order></author><author><firstname>Georgeta</firstname><surname>Vulpe</surname><order>3</order></author><author><firstname>Ana P. M.</firstname><surname>Tavares</surname><order>4</order></author><author><firstname>M. 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spelling v2 63391 2023-05-10 A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false d1d5815c60d63534a10a81489255c681 Georgeta Vulpe Georgeta Vulpe true false 2023-05-10 EAAS Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based PoCT device. Cork is known to be fully biodegradable and easily recycled without producing toxic residues. We report on how cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an "artificial antibody" can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg/mL, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. In addition, it has a huge environmental impact as it can reduce the waste generated by other polymeric/ceramic carriers used for the same purpose. Journal Article Sensors & Diagnostics 2 4 956 963 Royal Society of Chemistry (RSC) 2635-0998 9 5 2023 2023-05-09 10.1039/d3sd00022b COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University The authors acknowledge funding through project 2IQBioneuro with the reference (0624_2IQBIONEURO_6_E), entitled, Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases, EP-INTERREG V Spain Portugal (POCTEP). Daniela O. acknowledge funding from Fundação para a Ciência e Tecnologia, I.P., through the PhD grant reference SFRH/BD/137832/2018. This work was also supported by Multi-year funding of European Union (FEDER funds through Compete) and National Funds (FCT/MCTES) through Project UID/QUI/50006/2019 and UIDB/04730/2020. 2024-09-26T15:46:27.1178288 2023-05-10T14:18:35.3894177 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Bárbara Correia 1 Daniela Oliveira 2 Georgeta Vulpe 3 Ana P. M. Tavares 4 M. Goreti F. Sales 0000-0001-9936-7336 5 Abel J. Duarte 0000-0003-0218-1952 6 Sanjiv Sharma 0000-0003-3828-737X 7 Felismina T. C. Moreira 8 Georgeta Vulpe 9 63391__27769__4cb3100d79ff4981ab0b2c6455ea225c.pdf 63391.pdf 2023-06-08T15:21:01.4263592 Output 1499130 application/pdf Version of Record true Open Access Article. . This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence true eng http://creativecommons.org/licenses/by-nc/3.0/
title A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
spellingShingle A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
Sanjiv Sharma
Georgeta Vulpe
title_short A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_full A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_fullStr A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_full_unstemmed A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
title_sort A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers
author_id_str_mv b6b7506358522f607b171ec9c94757b7
d1d5815c60d63534a10a81489255c681
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
d1d5815c60d63534a10a81489255c681_***_Georgeta Vulpe
author Sanjiv Sharma
Georgeta Vulpe
author2 Bárbara Correia
Daniela Oliveira
Georgeta Vulpe
Ana P. M. Tavares
M. Goreti F. Sales
Abel J. Duarte
Sanjiv Sharma
Felismina T. C. Moreira
Georgeta Vulpe
format Journal article
container_title Sensors & Diagnostics
container_volume 2
container_issue 4
container_start_page 956
publishDate 2023
institution Swansea University
issn 2635-0998
doi_str_mv 10.1039/d3sd00022b
publisher Royal Society of Chemistry (RSC)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description Whilst the single use point of care testing (PoCT) devices has transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed employing devices made of environmentally friendly material. Herein, we report on the use of cork based PoCT device. Cork is known to be fully biodegradable and easily recycled without producing toxic residues. We report on how cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an "artificial antibody" can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg/mL, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. In addition, it has a huge environmental impact as it can reduce the waste generated by other polymeric/ceramic carriers used for the same purpose.
published_date 2023-05-09T15:46:25Z
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score 11.035874

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