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A new model for evaluating pressure-induced vascular tone in small cerebral arteries

Alberto Coccarelli Orcid Logo, Sanjay Pant, Ioannis Polydoros, Osama F. Harraz, Sanjay Pant Orcid Logo

Biomechanics and Modeling in Mechanobiology, Volume: 23, Issue: 1, Pages: 271 - 286

Swansea University Authors: Alberto Coccarelli Orcid Logo, Sanjay Pant Orcid Logo

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Abstract

The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological conditions. Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure a...

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Published in: Biomechanics and Modeling in Mechanobiology
ISSN: 1617-7959 1617-7940
Published: Springer Science and Business Media LLC 2024
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa64583
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Abstract: The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological conditions. Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure and vascular tone generation in SCAs. This is assembled by combining a chemical sub-model, representing pressure-induced smooth muscle cell (SMC) signalling, with a mechanical sub-model for the tone generation and its transduction at tissue level. The devised model can accurately reproduce the impact of luminal pressure on different cytoplasmic components involved in myogenic signalling, both in the control case and when combined with some specific pharmacological interventions. Furthermore, the model is also able to capture and predict experimentally recorded pressure-outer diameter relationships obtained for vessels under control conditions, both in a Ca-free bath and under drug inhibition. The modularity of the proposed framework allows the integration of new components for the study of a broad range of processes involved in the vascular function.
College: Faculty of Science and Engineering
Funders: A.C. and I.P. acknowledge the support by Swansea University through the College of Engineering Zienkiewicz/Centenary scholarship. O.F.H. was supported by the National Heart, Lung, and Blood Institute (R01HL169681), the National Institute of Aging (R21AG082193), the National Institute of General Medical Sciences (P20GM135007), the American Heart Association (20CDA35310097), the Totman Medical Research Trust, the Larner College of Medicine, University of Vermont, the Bloomfield Professorship in Cardiovascular Research, and the Cardiovascular Research Institute of Vermont.
Issue: 1
Start Page: 271
End Page: 286