Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins

Khatri, Vinod; Parshad, Badri; Prasad, Ashok K.; Bhatia, Sumati

doi:10.1002/ejoc.202201360

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Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins

Vinod Khatri, Badri Parshad, Ashok K. Prasad, Sumati Bhatia

European Journal of Organic Chemistry, Volume: 26, Issue: 9

Swansea University Author: Sumati Bhatia

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DOI (Published version): 10.1002/ejoc.202201360

Abstract

In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydr...

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Published in:	European Journal of Organic Chemistry
ISSN:	1434-193X 1099-0690
Published:	Wiley 2023
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa64853
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first_indexed	2023-11-17T18:17:37Z
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spelling	v2 64853 2023-11-01 Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2023-11-01 CHEM In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydrate ligand. Optimized glycotripods are high affinity binders and have been used for delivering drugs or even applied as drug candidates. The selection of the tripodal base scaffold together with the length and flexibility of the linker between the scaffold and sugar residue, as important design parameters are discussed in this review. Journal Article European Journal of Organic Chemistry 26 9 Wiley 1434-193X 1099-0690 Carbohydrates, Drug delivery, Glycotripod, Hemagglutinin, Lectin binder 1 3 2023 2023-03-01 10.1002/ejoc.202201360 http://dx.doi.org/10.1002/ejoc.202201360 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University Other We acknowledge the funding from the German Research Foundation (DFG) – project number 458564133 to support this work. Open Access funding enabled and organized by Projekt DEAL. 2023-12-04T12:44:40.3374981 2023-11-01T10:32:44.1624184 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Vinod Khatri 1 Badri Parshad 2 Ashok K. Prasad 3 Sumati Bhatia 0000-0002-5123-4937 4 64853__29181__f9d620db12f3467487de4a30dc445a3d.pdf 64853.VOR.pdf 2023-12-04T12:35:31.9592319 Output 9495217 application/pdf Version of Record true © 2023 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
spellingShingle	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins Sumati Bhatia
title_short	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
title_full	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
title_fullStr	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
title_full_unstemmed	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
title_sort	Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
author_id_str_mv	a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv	a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author	Sumati Bhatia
author2	Vinod Khatri Badri Parshad Ashok K. Prasad Sumati Bhatia
format	Journal article
container_title	European Journal of Organic Chemistry
container_volume	26
container_issue	9
publishDate	2023
institution	Swansea University
issn	1434-193X 1099-0690
doi_str_mv	10.1002/ejoc.202201360
publisher	Wiley
college_str	Faculty of Science and Engineering
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hierarchy_top_title	Faculty of Science and Engineering
hierarchy_parent_id	facultyofscienceandengineering
hierarchy_parent_title	Faculty of Science and Engineering
department_str	School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url	http://dx.doi.org/10.1002/ejoc.202201360
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description	In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding pockets which are highly selective for a particular carbohydrate ligand. Optimized glycotripods are high affinity binders and have been used for delivering drugs or even applied as drug candidates. The selection of the tripodal base scaffold together with the length and flexibility of the linker between the scaffold and sugar residue, as important design parameters are discussed in this review.
published_date	2023-03-01T12:44:41Z
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score	11.016235

Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins

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