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Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size

Shaohui Xu Orcid Logo, Sumati Bhatia Orcid Logo, Xin Fan, Philip Nickl, Rainer Haag Orcid Logo

Advanced Materials Interfaces, Volume: 9, Issue: 9

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/admi.202102315

Abstract

Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship betwe...

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Published in: Advanced Materials Interfaces
ISSN: 2196-7350 2196-7350
Published: Wiley 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa64857
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Abstract: Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship between its physiochemical properties and antibacterial activities has yet to be explored. This work is the first to investigate the combination effects of different sized and functionalized MoS2 sheets on their antibacterial activities. The bacterial capture abilities of 3 ┬Ám mannosylated, galactosylated, and glucosylated sheets, as well as 300 nm mannosylated sheets, all with similar sugar densities, are compared. Only mannosylated MoS2 sheets are found to agglutinate normal Escherichia coli (E. coli) and large mannosylated MoS2 sheets show the strongest E. coli agglutination. Despite slightly weaker photothermal performance under near-infrared (NIR) laser irradiation, large mannosylated MoS2 sheets exhibit higher antibacterial activity than the smaller sheets. By much stronger specific multivalent binding, large sheets capture E. coli more efficiently and compensate for their reduced photothermal activity. Besides providing a facile approach to eliminate E. coli bacteria, these findings offer valuable guidance for future development of 2D nanomaterial-based antibacterial agents and filter holder materials, where large-functionalized sheets can capture and eliminate bacteria powerfully.
College: Faculty of Science and Engineering
Issue: 9