Glycosylated MoS2 Sheets for Capturing and Deactivating E. coli Bacteria: Combined Effects of Multivalent Binding and Sheet Size

Xu, Shaohui; Bhatia, Sumati; Fan, Xin; Nickl, Philip; Haag, Rainer

doi:10.1002/admi.202102315

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Glycosylated MoS2 Sheets for Capturing and Deactivating E. coli Bacteria: Combined Effects of Multivalent Binding and Sheet Size

Shaohui Xu

, Sumati Bhatia

, Xin Fan, Philip Nickl, Rainer Haag

Advanced Materials Interfaces, Volume: 9, Issue: 9

Swansea University Author: Sumati Bhatia

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DOI (Published version): 10.1002/admi.202102315

Abstract

Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship betwe...

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Published in:	Advanced Materials Interfaces
ISSN:	2196-7350 2196-7350
Published:	Wiley 2022
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa64857

first_indexed	2023-11-17T18:27:43Z
last_indexed	2024-11-25T14:14:53Z
id	cronfa64857
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spelling	2023-12-21T15:05:48.7400933 v2 64857 2023-11-01 Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2023-11-01 EAAS Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship between its physiochemical properties and antibacterial activities has yet to be explored. This work is the first to investigate the combination effects of different sized and functionalized MoS2 sheets on their antibacterial activities. The bacterial capture abilities of 3 µm mannosylated, galactosylated, and glucosylated sheets, as well as 300 nm mannosylated sheets, all with similar sugar densities, are compared. Only mannosylated MoS2 sheets are found to agglutinate normal Escherichia coli (E. coli) and large mannosylated MoS2 sheets show the strongest E. coli agglutination. Despite slightly weaker photothermal performance under near-infrared (NIR) laser irradiation, large mannosylated MoS2 sheets exhibit higher antibacterial activity than the smaller sheets. By much stronger specific multivalent binding, large sheets capture E. coli more efficiently and compensate for their reduced photothermal activity. Besides providing a facile approach to eliminate E. coli bacteria, these findings offer valuable guidance for future development of 2D nanomaterial-based antibacterial agents and filter holder materials, where large-functionalized sheets can capture and eliminate bacteria powerfully. Journal Article Advanced Materials Interfaces 9 9 Wiley 2196-7350 2196-7350 1 3 2022 2022-03-01 10.1002/admi.202102315 http://dx.doi.org/10.1002/admi.202102315 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee 2023-12-21T15:05:48.7400933 2023-11-01T10:34:10.3542407 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Shaohui Xu 0000-0001-6470-2755 1 Sumati Bhatia 0000-0002-5123-4937 2 Xin Fan 3 Philip Nickl 4 Rainer Haag 0000-0003-3840-162x 5
title	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
spellingShingle	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size Sumati Bhatia
title_short	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_full	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_fullStr	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_full_unstemmed	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
title_sort	Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
author_id_str_mv	a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv	a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author	Sumati Bhatia
author2	Shaohui Xu Sumati Bhatia Xin Fan Philip Nickl Rainer Haag
format	Journal article
container_title	Advanced Materials Interfaces
container_volume	9
container_issue	9
publishDate	2022
institution	Swansea University
issn	2196-7350 2196-7350
doi_str_mv	10.1002/admi.202102315
publisher	Wiley
college_str	Faculty of Science and Engineering
hierarchytype
hierarchy_top_id	facultyofscienceandengineering
hierarchy_top_title	Faculty of Science and Engineering
hierarchy_parent_id	facultyofscienceandengineering
hierarchy_parent_title	Faculty of Science and Engineering
department_str	School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url	http://dx.doi.org/10.1002/admi.202102315
document_store_str	0
active_str	0
description	Molybdenum disulfide (MoS2) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship between its physiochemical properties and antibacterial activities has yet to be explored. This work is the first to investigate the combination effects of different sized and functionalized MoS2 sheets on their antibacterial activities. The bacterial capture abilities of 3 µm mannosylated, galactosylated, and glucosylated sheets, as well as 300 nm mannosylated sheets, all with similar sugar densities, are compared. Only mannosylated MoS2 sheets are found to agglutinate normal Escherichia coli (E. coli) and large mannosylated MoS2 sheets show the strongest E. coli agglutination. Despite slightly weaker photothermal performance under near-infrared (NIR) laser irradiation, large mannosylated MoS2 sheets exhibit higher antibacterial activity than the smaller sheets. By much stronger specific multivalent binding, large sheets capture E. coli more efficiently and compensate for their reduced photothermal activity. Besides providing a facile approach to eliminate E. coli bacteria, these findings offer valuable guidance for future development of 2D nanomaterial-based antibacterial agents and filter holder materials, where large-functionalized sheets can capture and eliminate bacteria powerfully.
published_date	2022-03-01T14:28:46Z
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score	11.564073

Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size

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