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Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action
Angewandte Chemie International Edition, Volume: 59, Issue: 36, Pages: 15532 - 15536
Swansea University Author:
Sumati Bhatia
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© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Distributed under the terms of a Creative Commons Attribution 4.0 International License (CC BY 4.0).
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DOI (Published version): 10.1002/anie.202004832
Abstract
In this study, we demonstrate the concept of “topology-matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effec...
Published in: | Angewandte Chemie International Edition |
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ISSN: | 1433-7851 1521-3773 |
Published: |
Wiley
2020
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Online Access: |
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URI: | https://cronfa.swan.ac.uk/Record/cronfa64863 |
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Abstract: |
In this study, we demonstrate the concept of “topology-matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24 hours after the infection, more than 99.999 % inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection. |
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Keywords: |
Antiviral agents, inhibitors, influenza, nanoparticles, topology matching |
College: |
Faculty of Science and Engineering |
Funders: |
The authors gratefully acknowledge financial support from Deutsche Forschungsgemeinschaft (DFG) through grants within the Collaborative Research Center (SFB) 765. C.N. acknowledges the support from China Scholarship Council (CSC). We would like to acknowledge the assistance of the Core Facility BioSupraMol supported by the DFG. Open access funding enabled and organized by Projekt DEAL. |
Issue: |
36 |
Start Page: |
15532 |
End Page: |
15536 |