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Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

Pallavi Kiran, Shalini Kumari, Jens Dernedde, Rainer Haag Orcid Logo, Sumati Bhatia Orcid Logo

New Journal of Chemistry, Volume: 43, Issue: 40, Pages: 16012 - 16016

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1039/c9nj02018g

Abstract

Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preferen...

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Published in: New Journal of Chemistry
ISSN: 1144-0546 1369-9261
Published: Royal Society of Chemistry (RSC) 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa64871
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last_indexed 2024-11-25T14:14:55Z
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spelling 2024-01-02T11:48:51.7006939 v2 64871 2023-11-01 Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2023-11-01 EAAS Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN. Journal Article New Journal of Chemistry 43 40 16012 16016 Royal Society of Chemistry (RSC) 1144-0546 1369-9261 11 9 2019 2019-09-11 10.1039/c9nj02018g http://dx.doi.org/10.1039/c9nj02018g COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2024-01-02T11:48:51.7006939 2023-11-01T10:41:05.1078737 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Pallavi Kiran 1 Shalini Kumari 2 Jens Dernedde 3 Rainer Haag 0000-0003-3840-162x 4 Sumati Bhatia 0000-0002-5123-4937 5
title Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
spellingShingle Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
Sumati Bhatia
title_short Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_full Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_fullStr Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_full_unstemmed Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_sort Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
author_id_str_mv a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author Sumati Bhatia
author2 Pallavi Kiran
Shalini Kumari
Jens Dernedde
Rainer Haag
Sumati Bhatia
format Journal article
container_title New Journal of Chemistry
container_volume 43
container_issue 40
container_start_page 16012
publishDate 2019
institution Swansea University
issn 1144-0546
1369-9261
doi_str_mv 10.1039/c9nj02018g
publisher Royal Society of Chemistry (RSC)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url http://dx.doi.org/10.1039/c9nj02018g
document_store_str 0
active_str 0
description Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN.
published_date 2019-09-11T14:28:49Z
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score 11.048042

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