No Cover Image

Journal article 726 views

Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding

Pallavi Kiran, Shalini Kumari, Jens Dernedde, Rainer Haag Orcid Logo, Sumati Bhatia Orcid Logo

New Journal of Chemistry, Volume: 43, Issue: 40, Pages: 16012 - 16016

Swansea University Author: Sumati Bhatia Orcid Logo

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1039/c9nj02018g

Abstract

Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preferen...

Full description

Published in: New Journal of Chemistry
ISSN: 1144-0546 1369-9261
Published: Royal Society of Chemistry (RSC) 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa64871
first_indexed 2023-11-17T18:54:39Z
last_indexed 2024-11-25T14:14:55Z
id cronfa64871
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2024-01-02T11:48:51.7006939</datestamp><bib-version>v2</bib-version><id>64871</id><entry>2023-11-01</entry><title>Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding</title><swanseaauthors><author><sid>a6b1181ebdbe42bd03b24cbdb559d082</sid><ORCID>0000-0002-5123-4937</ORCID><firstname>Sumati</firstname><surname>Bhatia</surname><name>Sumati Bhatia</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-11-01</date><deptcode>EAAS</deptcode><abstract>Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN.</abstract><type>Journal Article</type><journal>New Journal of Chemistry</journal><volume>43</volume><journalNumber>40</journalNumber><paginationStart>16012</paginationStart><paginationEnd>16016</paginationEnd><publisher>Royal Society of Chemistry (RSC)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1144-0546</issnPrint><issnElectronic>1369-9261</issnElectronic><keywords/><publishedDay>11</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-09-11</publishedDate><doi>10.1039/c9nj02018g</doi><url>http://dx.doi.org/10.1039/c9nj02018g</url><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2024-01-02T11:48:51.7006939</lastEdited><Created>2023-11-01T10:41:05.1078737</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Chemistry</level></path><authors><author><firstname>Pallavi</firstname><surname>Kiran</surname><order>1</order></author><author><firstname>Shalini</firstname><surname>Kumari</surname><order>2</order></author><author><firstname>Jens</firstname><surname>Dernedde</surname><order>3</order></author><author><firstname>Rainer</firstname><surname>Haag</surname><orcid>0000-0003-3840-162x</orcid><order>4</order></author><author><firstname>Sumati</firstname><surname>Bhatia</surname><orcid>0000-0002-5123-4937</orcid><order>5</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2024-01-02T11:48:51.7006939 v2 64871 2023-11-01 Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding a6b1181ebdbe42bd03b24cbdb559d082 0000-0002-5123-4937 Sumati Bhatia Sumati Bhatia true false 2023-11-01 EAAS Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN. Journal Article New Journal of Chemistry 43 40 16012 16016 Royal Society of Chemistry (RSC) 1144-0546 1369-9261 11 9 2019 2019-09-11 10.1039/c9nj02018g http://dx.doi.org/10.1039/c9nj02018g COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2024-01-02T11:48:51.7006939 2023-11-01T10:41:05.1078737 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Pallavi Kiran 1 Shalini Kumari 2 Jens Dernedde 3 Rainer Haag 0000-0003-3840-162x 4 Sumati Bhatia 0000-0002-5123-4937 5
title Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
spellingShingle Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
Sumati Bhatia
title_short Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_full Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_fullStr Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_full_unstemmed Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
title_sort Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
author_id_str_mv a6b1181ebdbe42bd03b24cbdb559d082
author_id_fullname_str_mv a6b1181ebdbe42bd03b24cbdb559d082_***_Sumati Bhatia
author Sumati Bhatia
author2 Pallavi Kiran
Shalini Kumari
Jens Dernedde
Rainer Haag
Sumati Bhatia
format Journal article
container_title New Journal of Chemistry
container_volume 43
container_issue 40
container_start_page 16012
publishDate 2019
institution Swansea University
issn 1144-0546
1369-9261
doi_str_mv 10.1039/c9nj02018g
publisher Royal Society of Chemistry (RSC)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url http://dx.doi.org/10.1039/c9nj02018g
document_store_str 0
active_str 0
description Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN.
published_date 2019-09-11T05:10:51Z
_version_ 1851730953695657984
score 11.089864

Similar Items