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Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt

Dean R. Perkins Orcid Logo, Jack S. Talbot, Rachel N. Lord, Tony G. Dawkins, Aaron L. Baggish, Abbas Zaidi, Orhan Uzun, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Stephen-Mark Cooper, Rhodri S. Lloyd, Jon L. Oliver, Rob E. Shave, Mike Stembridge

Journal of the American Society of Echocardiography

Swansea University Authors: Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo

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Abstract

BackgroundThe extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this structural adaptation is often associated with the adaptation of left ventricular (LV) twist mechanics. For example, an increase in LV twist often follows an expansion in en...

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Published in: Journal of the American Society of Echocardiography
ISSN: 0894-7317
Published: Elsevier BV 2023
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa65224
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Abstract: BackgroundThe extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this structural adaptation is often associated with the adaptation of left ventricular (LV) twist mechanics. For example, an increase in LV twist often follows an expansion in end-diastolic volume, whereas a reduction in twist may follow a thickening of the LV walls. While structural cardiac remodeling has been shown to be more prominent post–peak height velocity (PHV), it remains to be determined how this maturation-dependent structural remodeling influences LV twist. Therefore, we aimed to (1) compare LV twist mechanics between trained and untrained children pre- and post-PHV and (2) investigate how LV structural variables relate to LV twist mechanics pre- and post-PHV.MethodsLeft ventricular function and morphology were assessed (echocardiography) in endurance-trained and untrained boys (n = 38 and n = 28, respectively) and girls (n = 39 and n = 34, respectively). Participants were categorized as either pre- or post-PHV using maturity offset to estimate somatic maturation.ResultsPre-PHV, there were no differences in LV twist or torsion between trained and untrained boys (twist: P = .630; torsion: P = .382) or girls (twist: P = .502; torsion: P = .316), and LV twist mechanics were not related with any LV structural variables (P > .05). Post-PHV, LV twist was lower in trained versus untrained boys (P = .004), with torsion lower in trained groups, irrespective of sex (boys: P < .001; girls: P = .017). Moreover, LV torsion was inversely related to LV mass (boys: r = −0.55, P = .001; girls: r = −0.46, P = .003) and end-diastolic volume (boys: r = −0.64, P < .001; girls: r = −0.36, P = .025) in both sexes.ConclusionsA difference in LV twist mechanics between endurance-trained and untrained cohorts is only apparent post-PHV, where structural and functional remodeling were related.
Keywords: echocardiography, myocardium, twist, youth, exercise
College: Faculty of Science and Engineering