Book chapter 184 views
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
Pain Management - Practices, Novel Therapies and Bioactives
Swansea University Authors:
Shane Heffernan , Gill Conway
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DOI (Published version): 10.5772/intechopen.95919
Abstract
Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all those over 50 years, globally) and is the most common cause of join...
Published in: | Pain Management - Practices, Novel Therapies and Bioactives |
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ISBN: | 9781838800260 9781838808976 |
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IntechOpen
2021
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URI: | https://cronfa.swan.ac.uk/Record/cronfa65436 |
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v2 65436 2024-01-10 Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false e33e0ee5a076ad91fe6615117caa1800 0000-0002-5991-0960 Gill Conway Gill Conway true false 2024-01-10 STSC Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all those over 50 years, globally) and is the most common cause of joint pain. The prevalence of non-steroidal anti-inflammatory drug (NSAIDs) and analgesic use has been well studied and is abundant throughout the western world, with women being the greatest users and ibuprofen generally being the most reported NSAID. In the US, 65% of all OA patients are prescribed NSAIDs for pain management and form part of the current recommended strategy for OA clinical management. While some NSAIDs and analgesics are effective at improving pain and physical function, they come with significant and harmful side effects such as gastrointestinal complications, renal disturbances and severe cardiovascular events. Given these side-effects, any reduction in NSAID and analgesia use (and the resulting potentially harmful side effects) is of particular importance to OA public health. As such, a number of non-pharmaceutical alternatives (bioactive nutraceuticals) have been developed that may reduce NSAID and analgesia use while maintaining pain reduction and improvements in physical function. This chapter will discuss select nutraceuticals that are not currently in mainstream use but may have the potential to aid in the treatment of OA. Book chapter Pain Management - Practices, Novel Therapies and Bioactives IntechOpen 9781838800260 9781838808976 joint pain; pain medication; non-pharmacological pain management; mechanisms of pain and action; paracetamol (acetaminophenN-acetyl-p-aminophenol; APAP); opioids 1 3 2021 2021-03-01 10.5772/intechopen.95919 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2024-03-23T12:43:58.1567407 2024-01-10T15:28:11.5738291 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Shane Heffernan 0000-0002-3297-9335 1 Gill Conway 0000-0002-5991-0960 2 |
title |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis |
spellingShingle |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis Shane Heffernan Gill Conway |
title_short |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis |
title_full |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis |
title_fullStr |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis |
title_full_unstemmed |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis |
title_sort |
Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis |
author_id_str_mv |
72c0b36891dfbec0378c0d0f7916e807 e33e0ee5a076ad91fe6615117caa1800 |
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72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan e33e0ee5a076ad91fe6615117caa1800_***_Gill Conway |
author |
Shane Heffernan Gill Conway |
author2 |
Shane Heffernan Gill Conway |
format |
Book chapter |
container_title |
Pain Management - Practices, Novel Therapies and Bioactives |
publishDate |
2021 |
institution |
Swansea University |
isbn |
9781838800260 9781838808976 |
doi_str_mv |
10.5772/intechopen.95919 |
publisher |
IntechOpen |
college_str |
Faculty of Medicine, Health and Life Sciences |
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|
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science |
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description |
Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all those over 50 years, globally) and is the most common cause of joint pain. The prevalence of non-steroidal anti-inflammatory drug (NSAIDs) and analgesic use has been well studied and is abundant throughout the western world, with women being the greatest users and ibuprofen generally being the most reported NSAID. In the US, 65% of all OA patients are prescribed NSAIDs for pain management and form part of the current recommended strategy for OA clinical management. While some NSAIDs and analgesics are effective at improving pain and physical function, they come with significant and harmful side effects such as gastrointestinal complications, renal disturbances and severe cardiovascular events. Given these side-effects, any reduction in NSAID and analgesia use (and the resulting potentially harmful side effects) is of particular importance to OA public health. As such, a number of non-pharmaceutical alternatives (bioactive nutraceuticals) have been developed that may reduce NSAID and analgesia use while maintaining pain reduction and improvements in physical function. This chapter will discuss select nutraceuticals that are not currently in mainstream use but may have the potential to aid in the treatment of OA. |
published_date |
2021-03-01T12:43:55Z |
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1794320981421981696 |
score |
11.021648 |