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A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
Annals of Biomedical Engineering
Swansea University Authors:
Alberto Coccarelli , Raoul van Loon
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DOI (Published version): 10.1007/s10439-024-03493-1
Abstract
Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related...
Published in: | Annals of Biomedical Engineering |
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ISSN: | 0090-6964 1573-9686 |
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Springer Science and Business Media LLC
2024
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URI: | https://cronfa.swan.ac.uk/Record/cronfa65905 |
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v2 65905 2024-03-26 A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 880b30f90841a022f1e5bac32fb12193 0000-0003-3581-5827 Raoul van Loon Raoul van Loon true false 2024-03-26 ACEM Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related with intracranial aneurysm (IA) growth. In this work, we introduced a novel reduced-order modelling strategy for the systematic quantification of longitudinal blood flow changes across the whole CoW in patients with stable and unstable/growing aneurysm. Magnetic Resonance Angiography (MRA) images were converted into one-dimensional (1-D) vessel networks through a semi-automated procedure, with a level of geometric reconstruction accuracy controlled by user-dependent parameters. The proposed pipeline was used to systematically analyse longitudinal haemodynamic changes in seven different clinical cases. Our preliminary simulation results indicate that growing aneurysms are not necessarily associated with significant changes in mean flow over time. A concise sensitivity analysis also shed light on which modelling aspects need to be further characterized in order to have reliable patient-specific predictions. This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms. Journal Article Annals of Biomedical Engineering 0 Springer Science and Business Media LLC 0090-6964 1573-9686 Circle of Willis; Aneurysm development; Cerebral vasculature; One-dimensional blood flow dynamics; Longitudinal study 14 4 2024 2024-04-14 10.1007/s10439-024-03493-1 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University SU Library paid the OA fee (TA Institutional Deal) Aichi Chien acknowledges the funding provided by Foundation for the National Institutes of Health (R01HL152270). 2024-05-31T15:35:46.2883368 2024-03-26T09:16:25.1960296 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Raoul van Loon 0000-0003-3581-5827 2 Aichi Chien 3 65905__30024__acc5c8f8308d49c5b2e9ed7bc7bc5d71.pdf 65905.VOR.pdf 2024-04-15T17:19:02.7408474 Output 2791833 application/pdf Version of Record true © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/ |
title |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms |
spellingShingle |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms Alberto Coccarelli Raoul van Loon |
title_short |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms |
title_full |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms |
title_fullStr |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms |
title_full_unstemmed |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms |
title_sort |
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms |
author_id_str_mv |
06fd3332e5eb3cf4bb4e75a24f49149d 880b30f90841a022f1e5bac32fb12193 |
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06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli 880b30f90841a022f1e5bac32fb12193_***_Raoul van Loon |
author |
Alberto Coccarelli Raoul van Loon |
author2 |
Alberto Coccarelli Raoul van Loon Aichi Chien |
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Annals of Biomedical Engineering |
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10.1007/s10439-024-03493-1 |
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Springer Science and Business Media LLC |
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description |
Changes in cerebral blood flow are often associated with the initiation and development of different life-threatening medical conditions including aneurysm rupture and ischemic stroke. Nevertheless, it is not fully clear how haemodynamic changes in time across the Circle of Willis (CoW) are related with intracranial aneurysm (IA) growth. In this work, we introduced a novel reduced-order modelling strategy for the systematic quantification of longitudinal blood flow changes across the whole CoW in patients with stable and unstable/growing aneurysm. Magnetic Resonance Angiography (MRA) images were converted into one-dimensional (1-D) vessel networks through a semi-automated procedure, with a level of geometric reconstruction accuracy controlled by user-dependent parameters. The proposed pipeline was used to systematically analyse longitudinal haemodynamic changes in seven different clinical cases. Our preliminary simulation results indicate that growing aneurysms are not necessarily associated with significant changes in mean flow over time. A concise sensitivity analysis also shed light on which modelling aspects need to be further characterized in order to have reliable patient-specific predictions. This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms. |
published_date |
2024-04-14T15:35:45Z |
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11.021648 |