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Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia

Grace Bailey Orcid Logo, Clare Matthews, Konrad Szewczyk-krolikowski, Peter Moore, Sandra Komarzynski, Elin Haf Davies, Kathryn J. Peall Orcid Logo

Journal of Neurology, Volume: 270, Issue: 3, Pages: 1759 - 1769

Swansea University Author: Grace Bailey Orcid Logo

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DOI (Published version): 10.1007/s00415-022-11490-4

Abstract

BackgroundUp to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties with sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep archite...

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Published in: Journal of Neurology
ISSN: 0340-5354 1432-1459
Published: Springer Science and Business Media LLC 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa66532
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Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep architecture.MethodsTo measure activity during the sleep/wake cycle, individuals wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing a daily sleep diary and standardised sleep and non-motor questionnaires via a dedicated app. Sleep measures were derived from the captured raw triaxial acceleration and heart rate values using previously published validated algorithms.ResultsData were collected from 50 individuals diagnosed with AOIFCD and 47 age- and sex-matched controls. Those with AOIFCD self-reported significantly higher levels of excessive daytime sleepiness (p = 0.04) and impaired sleep quality (p = 0.03), while accelerometer measurements found the AOIFCD cohort to have significantly longer total sleep times (p = 0.004) and time spent in NREM sleep (p = 0.009), compared to controls. Overall, there was limited agreement between wearable-derived sleep parameters, and self-reported sleep diary and visual analogue scale records.DiscussionThis study shows the potential feasibility of using consumer-grade wearable devices in estimating sleep measures at scale in dystonia cohorts. Those diagnosed with AOIFCD were observed to have altered sleep architecture, notably longer total sleep time and NREM sleep, compared to controls. 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KJP is funded by an MRC Clinician-Scientist Fellowship (MR/P008593/1).</funders><projectreference/><lastEdited>2024-06-19T15:49:39.6875059</lastEdited><Created>2024-05-29T20:04:20.0867919</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Health Data Science</level></path><authors><author><firstname>Grace</firstname><surname>Bailey</surname><orcid>0000-0003-4646-3134</orcid><order>1</order></author><author><firstname>Clare</firstname><surname>Matthews</surname><order>2</order></author><author><firstname>Konrad</firstname><surname>Szewczyk-krolikowski</surname><order>3</order></author><author><firstname>Peter</firstname><surname>Moore</surname><order>4</order></author><author><firstname>Sandra</firstname><surname>Komarzynski</surname><order>5</order></author><author><firstname>Elin Haf</firstname><surname>Davies</surname><order>6</order></author><author><firstname>Kathryn J.</firstname><surname>Peall</surname><orcid>0000-0003-4749-4944</orcid><order>7</order></author></authors><documents><document><filename>66532__30683__b51d36432b7d4bf9b48ece68d590e83e.pdf</filename><originalFilename>66532.VoR.pdf</originalFilename><uploaded>2024-06-19T15:47:57.7632396</uploaded><type>Output</type><contentLength>1775821</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© The Author(s) 2022. 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spelling v2 66532 2024-05-29 Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia 1e09a407fca9e8047e7738b18d381130 0000-0003-4646-3134 Grace Bailey Grace Bailey true false 2024-05-29 MEDS BackgroundUp to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties with sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep architecture.MethodsTo measure activity during the sleep/wake cycle, individuals wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing a daily sleep diary and standardised sleep and non-motor questionnaires via a dedicated app. Sleep measures were derived from the captured raw triaxial acceleration and heart rate values using previously published validated algorithms.ResultsData were collected from 50 individuals diagnosed with AOIFCD and 47 age- and sex-matched controls. Those with AOIFCD self-reported significantly higher levels of excessive daytime sleepiness (p = 0.04) and impaired sleep quality (p = 0.03), while accelerometer measurements found the AOIFCD cohort to have significantly longer total sleep times (p = 0.004) and time spent in NREM sleep (p = 0.009), compared to controls. Overall, there was limited agreement between wearable-derived sleep parameters, and self-reported sleep diary and visual analogue scale records.DiscussionThis study shows the potential feasibility of using consumer-grade wearable devices in estimating sleep measures at scale in dystonia cohorts. Those diagnosed with AOIFCD were observed to have altered sleep architecture, notably longer total sleep time and NREM sleep, compared to controls. These findings suggest that previously reported disruptions to brainstem circuitry and serotonin neurotransmission may contribute to both motor and sleep pathophysiology. Journal Article Journal of Neurology 270 3 1759 1769 Springer Science and Business Media LLC 0340-5354 1432-1459 Dystonia; Sleep; Non-motor; Wearable devices; Accelerometry 1 3 2023 2023-03-01 10.1007/s00415-022-11490-4 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee GAB is funded by a KESS2, European Social Fund and Cardiff University PhD Studentship in partnership with Aparito Limited. KJP is funded by an MRC Clinician-Scientist Fellowship (MR/P008593/1). 2024-06-19T15:49:39.6875059 2024-05-29T20:04:20.0867919 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Grace Bailey 0000-0003-4646-3134 1 Clare Matthews 2 Konrad Szewczyk-krolikowski 3 Peter Moore 4 Sandra Komarzynski 5 Elin Haf Davies 6 Kathryn J. Peall 0000-0003-4749-4944 7 66532__30683__b51d36432b7d4bf9b48ece68d590e83e.pdf 66532.VoR.pdf 2024-06-19T15:47:57.7632396 Output 1775821 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
spellingShingle Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
Grace Bailey
title_short Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
title_full Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
title_fullStr Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
title_full_unstemmed Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
title_sort Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia
author_id_str_mv 1e09a407fca9e8047e7738b18d381130
author_id_fullname_str_mv 1e09a407fca9e8047e7738b18d381130_***_Grace Bailey
author Grace Bailey
author2 Grace Bailey
Clare Matthews
Konrad Szewczyk-krolikowski
Peter Moore
Sandra Komarzynski
Elin Haf Davies
Kathryn J. Peall
format Journal article
container_title Journal of Neurology
container_volume 270
container_issue 3
container_start_page 1759
publishDate 2023
institution Swansea University
issn 0340-5354
1432-1459
doi_str_mv 10.1007/s00415-022-11490-4
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
active_str 0
description BackgroundUp to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties with sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep architecture.MethodsTo measure activity during the sleep/wake cycle, individuals wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing a daily sleep diary and standardised sleep and non-motor questionnaires via a dedicated app. Sleep measures were derived from the captured raw triaxial acceleration and heart rate values using previously published validated algorithms.ResultsData were collected from 50 individuals diagnosed with AOIFCD and 47 age- and sex-matched controls. Those with AOIFCD self-reported significantly higher levels of excessive daytime sleepiness (p = 0.04) and impaired sleep quality (p = 0.03), while accelerometer measurements found the AOIFCD cohort to have significantly longer total sleep times (p = 0.004) and time spent in NREM sleep (p = 0.009), compared to controls. Overall, there was limited agreement between wearable-derived sleep parameters, and self-reported sleep diary and visual analogue scale records.DiscussionThis study shows the potential feasibility of using consumer-grade wearable devices in estimating sleep measures at scale in dystonia cohorts. Those diagnosed with AOIFCD were observed to have altered sleep architecture, notably longer total sleep time and NREM sleep, compared to controls. These findings suggest that previously reported disruptions to brainstem circuitry and serotonin neurotransmission may contribute to both motor and sleep pathophysiology.
published_date 2023-03-01T15:49:38Z
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