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Lumbriculus variegatus: Investigating a Novel in vivo Model for Substances of Abuse / ROMESSA MAHMOOD

Swansea University Author: ROMESSA MAHMOOD

Abstract

To replace, reduce and refine using vertebrates in pharmacological research, invertebrate in vivo models are required to continue investigating pharmacology in whole animal systems. This study presents the freshwater oligochaete worm Lumbriculus variegatus as a novel in vivo invertebrate model to st...

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Published: Swansea, Wales, UK 2024
Institution: Swansea University
Degree level: Master of Research
Degree name: MSc by Research
Supervisor: Wallace, Lisa ; Davies, Nia ; Seeley, Aidan
URI: https://cronfa.swan.ac.uk/Record/cronfa66584
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Abstract: To replace, reduce and refine using vertebrates in pharmacological research, invertebrate in vivo models are required to continue investigating pharmacology in whole animal systems. This study presents the freshwater oligochaete worm Lumbriculus variegatus as a novel in vivo invertebrate model to study the behavioural and physiological effects of ethanol and nicotine, two widely used substances of abuse.
Keywords: Invertebrates, models, animals, ethanol, nicotine, oligochaetes, substances of abuse
College: Faculty of Medicine, Health and Life Sciences