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Lumbriculus variegatus: Investigating a Novel in vivo Model for Substances of Abuse / ROMESSA MAHMOOD
Swansea University Author: ROMESSA MAHMOOD
Abstract
To replace, reduce and refine using vertebrates in pharmacological research, invertebrate in vivo models are required to continue investigating pharmacology in whole animal systems. This study presents the freshwater oligochaete worm Lumbriculus variegatus as a novel in vivo invertebrate model to st...
| Published: |
Swansea, Wales, UK
2024
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| Institution: | Swansea University |
| Degree level: | Master of Research |
| Degree name: | MSc by Research |
| Supervisor: | Wallace, Lisa ; Davies, Nia ; Seeley, Aidan |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa66584 |
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| Abstract: |
To replace, reduce and refine using vertebrates in pharmacological research, invertebrate in vivo models are required to continue investigating pharmacology in whole animal systems. This study presents the freshwater oligochaete worm Lumbriculus variegatus as a novel in vivo invertebrate model to study the behavioural and physiological effects of ethanol and nicotine, two widely used substances of abuse. |
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| Keywords: |
Invertebrates, models, animals, ethanol, nicotine, oligochaetes, substances of abuse |
| College: |
Faculty of Medicine, Health and Life Sciences |