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Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.

Aimee Drane Orcid Logo

Communications Biology, Volume: 7, Issue: 682

Swansea University Author: Aimee Drane Orcid Logo

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DOI (Published version): https://doi.org/10.1038/s42003-024-06280-9

Abstract

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon,...

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Published in: Communications Biology
Published: Nature 2024
Online Access: https://www.nature.com/articles/s42003-024-06280-9#citeas
URI: https://cronfa.swan.ac.uk/Record/cronfa66968
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spelling v2 66968 2024-07-05 Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype. 32adcb7b814aa529984f3a80d902215f 0000-0002-5208-917X Aimee Drane Aimee Drane true false 2024-07-05 HSOC Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche. Journal Article Communications Biology 7 682 Nature 14 6 2024 2024-06-14 https://doi.org/10.1038/s42003-024-06280-9 https://www.nature.com/articles/s42003-024-06280-9#citeas COLLEGE NANME Health and Social Care School COLLEGE CODE HSOC Swansea University Another institution paid the OA fee 2024-07-05T16:00:37.1603530 2024-07-05T14:54:16.3289219 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Healthcare Science Aimee Drane 0000-0002-5208-917X 1 259
title Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
spellingShingle Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
Aimee Drane
title_short Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
title_full Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
title_fullStr Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
title_full_unstemmed Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
title_sort Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.
author_id_str_mv 32adcb7b814aa529984f3a80d902215f
author_id_fullname_str_mv 32adcb7b814aa529984f3a80d902215f_***_Aimee Drane
author Aimee Drane
author2 Aimee Drane
format Journal article
container_title Communications Biology
container_volume 7
container_issue 682
publishDate 2024
institution Swansea University
doi_str_mv https://doi.org/10.1038/s42003-024-06280-9
publisher Nature
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Healthcare Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Healthcare Science
url https://www.nature.com/articles/s42003-024-06280-9#citeas
document_store_str 0
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description Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.
published_date 2024-06-14T16:00:35Z
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score 11.016235

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