COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales

Gu, Xinchun; Agrawal, Utkarsh; Midgley, Will; Bedston, Stuart; Anand, Sneha N.; Goudie, Rosalind; Byford, Rachel; Joy, Mark; Jamie, Gavin; Hoang, Uy; Ordóñez-Mena, Jose M.; Robertson, Chris; Richard, F. D.; Akbari, Ashley; Sheikh, Aziz; Lusignan, Simon de

doi:10.1038/s41541-024-00934-9

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COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales

Xinchun Gu

, Utkarsh Agrawal, Will Midgley

, Stuart Bedston, Sneha N. Anand, Rosalind Goudie, Rachel Byford, Mark Joy, Gavin Jamie

, Uy Hoang, Jose M. Ordóñez-Mena, Chris Robertson

, F. D. Richard Hobbs, Ashley Akbari

, Aziz Sheikh

, Simon de Lusignan

npj Vaccines, Volume: 9, Issue: 1

Swansea University Authors: Will Midgley , Stuart Bedston, Ashley Akbari

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DOI (Published version): 10.1038/s41541-024-00934-9

Abstract

Vaccines against COVID-19 and influenza can reduce the adverse outcomes caused by infections during pregnancy, but vaccine uptake among pregnant women has been suboptimal. We examined the COVID-19 and influenza vaccine uptake and disparities in pregnant women during the COVID-19 pandemic to inform v...

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Published in:	npj Vaccines
ISSN:	2059-0105
Published:	Springer Science and Business Media LLC 2024
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URI:	https://cronfa.swan.ac.uk/Record/cronfa67408
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This work was supported by the Con-COV team funded by the Medical Research Council (grant number: MR/V028367/1). This work was supported by Health Data Research UK, which receives its funding from HDRUKLtd (HDR 9006), funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), and the Wellcome Trust. 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spelling	v2 67408 2024-08-18 COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales c5be705247fb78c27cb7924683c60406 0000-0001-7198-7613 Will Midgley Will Midgley true false c79d07eaba5c9515c0df82b372b76a41 Stuart Bedston Stuart Bedston true false aa1b025ec0243f708bb5eb0a93d6fb52 0000-0003-0814-0801 Ashley Akbari Ashley Akbari true false 2024-08-18 MEDS Vaccines against COVID-19 and influenza can reduce the adverse outcomes caused by infections during pregnancy, but vaccine uptake among pregnant women has been suboptimal. We examined the COVID-19 and influenza vaccine uptake and disparities in pregnant women during the COVID-19 pandemic to inform vaccination interventions. We used data from the Oxford-Royal College of General Practitioners Research and Surveillance Centre database in England and the Secure Anonymised Information Linkage Databank in Wales. The uptake of at least one dose of vaccine was 40.2% for COVID-19 and 41.8% for influenza among eligible pregnant women. We observed disparities in COVID-19 and influenza vaccine uptake, with socioeconomically deprived and ethnic minority groups showing lower vaccination rates. The suboptimal uptake of COVID-19 and influenza vaccines, especially in those from socioeconomically deprived backgrounds and Black, mixed or other ethnic groups, underscores the necessity for interventions to reduce vaccine hesitancy and enhance acceptance in pregnant women. Journal Article npj Vaccines 9 1 Springer Science and Business Media LLC 2059-0105 14 8 2024 2024-08-14 10.1038/s41541-024-00934-9 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University ThisresearchispartoftheDataandConnectivityNationalCoreStudy,ledby HealthDataResearchUKinpartnershipwiththeOfficeforNationalStatistics and funded by UK Research and Innovation (grant ref MC_PC_20058).This work was also supported by The Alan Turing Institute via ‘Towards Turing 2.0’ EPSRC Grant Funding. This work was supported by the Con-COV team funded by the Medical Research Council (grant number: MR/V028367/1). This work was supported by Health Data Research UK, which receives its funding from HDRUKLtd (HDR 9006), funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), and the Wellcome Trust. Data and Connectivity: COVID-19 Vaccines Pharmacovigilance National Core Study— Uptake, safety and effectiveness of COVID-19 vaccines in pregnancy; children and young people; those receiving booster doses; and disease caused by different variants (2021.0158) is a partnership between the University of Edinburgh, University of Oxford, University of Strathclyde, Queen’s University Belfast, Swansea University, Imperial College London and the Office for National Statistics. Additionally, the authors acknowledge the support of BREATHE—The Health DataResearch Hub for Respiratory Health (MC_PC_19004), which is funded through the UK Research and Innovation Industrial Strategy Challenge Fundand delivered through Health Data Research UK. The authors would like to acknowledge all other project collaborators not involved in these analyses but contributing to wider discussions and preceding outputs. 2024-09-20T11:39:55.3029012 2024-08-18T15:34:16.2857799 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Xinchun Gu 0000-0002-2202-6792 1 Utkarsh Agrawal 2 Will Midgley 0000-0001-7198-7613 3 Stuart Bedston 4 Sneha N. Anand 5 Rosalind Goudie 6 Rachel Byford 7 Mark Joy 8 Gavin Jamie 0000-0001-9147-7784 9 Uy Hoang 10 Jose M. Ordóñez-Mena 11 Chris Robertson 0000-0001-6848-5241 12 F. D. Richard Hobbs 13 Ashley Akbari 0000-0003-0814-0801 14 Aziz Sheikh 0000-0001-7022-3056 15 Simon de Lusignan 0000-0002-8553-2641 16 67408__31411__57952b9d8fac484c8ca36804f248b0d6.pdf 67408.VoR.pdf 2024-09-20T11:37:39.0568613 Output 1350027 application/pdf Version of Record true © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
spellingShingle	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales Will Midgley Stuart Bedston Ashley Akbari
title_short	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
title_full	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
title_fullStr	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
title_full_unstemmed	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
title_sort	COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales
author_id_str_mv	c5be705247fb78c27cb7924683c60406 c79d07eaba5c9515c0df82b372b76a41 aa1b025ec0243f708bb5eb0a93d6fb52
author_id_fullname_str_mv	c5be705247fb78c27cb7924683c60406_*_Will Midgley c79d07eaba5c9515c0df82b372b76a41__Stuart Bedston aa1b025ec0243f708bb5eb0a93d6fb52_**_Ashley Akbari
author	Will Midgley Stuart Bedston Ashley Akbari
author2	Xinchun Gu Utkarsh Agrawal Will Midgley Stuart Bedston Sneha N. Anand Rosalind Goudie Rachel Byford Mark Joy Gavin Jamie Uy Hoang Jose M. Ordóñez-Mena Chris Robertson F. D. Richard Hobbs Ashley Akbari Aziz Sheikh Simon de Lusignan
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container_title	npj Vaccines
container_volume	9
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publishDate	2024
institution	Swansea University
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doi_str_mv	10.1038/s41541-024-00934-9
publisher	Springer Science and Business Media LLC
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
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description	Vaccines against COVID-19 and influenza can reduce the adverse outcomes caused by infections during pregnancy, but vaccine uptake among pregnant women has been suboptimal. We examined the COVID-19 and influenza vaccine uptake and disparities in pregnant women during the COVID-19 pandemic to inform vaccination interventions. We used data from the Oxford-Royal College of General Practitioners Research and Surveillance Centre database in England and the Secure Anonymised Information Linkage Databank in Wales. The uptake of at least one dose of vaccine was 40.2% for COVID-19 and 41.8% for influenza among eligible pregnant women. We observed disparities in COVID-19 and influenza vaccine uptake, with socioeconomically deprived and ethnic minority groups showing lower vaccination rates. The suboptimal uptake of COVID-19 and influenza vaccines, especially in those from socioeconomically deprived backgrounds and Black, mixed or other ethnic groups, underscores the necessity for interventions to reduce vaccine hesitancy and enhance acceptance in pregnant women.
published_date	2024-08-14T11:39:54Z
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COVID-19 and influenza vaccine uptake among pregnant women in national cohorts of England and Wales

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