No Cover Image

Journal article 55 views 16 downloads

Short QT intervals in African lions

Frederik S. Scharling, Ditte‐Mari Sandgreen, Julia Stagegaard, Vibeke S. Elbrønd, Stefano Vincenti, Jonas L. Isaksen, Tobias Wang, Rory Wilson Orcid Logo, Richard Gunner, Nikki Marks, Stephen H. Bell, Martin C. van Rooyen, Nigel C. Bennett, Daniel W. Hart, Angela C. Daly, Mads F. Bertelsen, D. Michael Scantlebury, Kirstine Calloe, Morten B. Thomsen Orcid Logo

Experimental Physiology

Swansea University Author: Rory Wilson Orcid Logo

  • 67695.VoR.pdf

    PDF | Version of Record

    © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License.

    Download (2.95MB)

Check full text

DOI (Published version): 10.1113/ep092203

Abstract

The cardiac conduction system in large carnivores, such as the African lion (Panthera leo), represents a significant knowledge gap in both veterinary science and in cardiac electrophysiology. Short QT intervals have been reported from zoo-kept, anaesthetized lions, and our goal was to record the fir...

Full description

Published in: Experimental Physiology
ISSN: 0958-0670 1469-445X
Published: Wiley 2024
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa67695
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2024-10-24T11:14:38Z
last_indexed 2024-10-24T11:14:38Z
id cronfa67695
recordtype SURis
fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>67695</id><entry>2024-09-16</entry><title>Short QT intervals in African lions</title><swanseaauthors><author><sid>017bc6dd155098860945dc6249c4e9bc</sid><ORCID>0000-0003-3177-0177</ORCID><firstname>Rory</firstname><surname>Wilson</surname><name>Rory Wilson</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-09-16</date><deptcode>BGPS</deptcode><abstract>The cardiac conduction system in large carnivores, such as the African lion (Panthera leo), represents a significant knowledge gap in both veterinary science and in cardiac electrophysiology. Short QT intervals have been reported from zoo-kept, anaesthetized lions, and our goal was to record the first ECGs from wild, conscious lions roaming freely, and compare them to zoo-kept lions under the hypothesis that short QT is unique to zoo-kept lions. Macroscopic and histological examinations were performed on heart tissue removed from nine healthy zoo lions. ECGs were recorded from the nine anaesthetized zoo-kept lions, and from 15 anaesthetized and conscious wild lions in Africa. Our histological and topographical description of the lion's heart matched what has previously been published. In conscious lions, the ECG recordings revealed a mean heart rate of 70 ± 4 beats/min, with faster heart rates during the night. PQ and QT intervals were heart rate dependent in the conscious lions. Interestingly, QT intervals recorded in wild lions were markedly longer than QT intervals from zoo lions (398 ± 40 vs. 297 ± 9 ms, respectively; P &lt; 0.0001). Anaesthesia or heart rate did not account for this difference. We provide a comprehensive description of the cardiac anatomy and electrophysiology of wild and zoo-kept lions. QT intervals were significantly shorter in zoo lions, suggesting functional disparities in cardiac electrophysiology between wild and zoo-kept lions, potentially related to physical fitness. These findings underscore the plasticity of cardiac electrophysiology and may be of value when reintroducing endangered species into the wild and when managing lions in human care.</abstract><type>Journal Article</type><journal>Experimental Physiology</journal><volume>0</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Wiley</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0958-0670</issnPrint><issnElectronic>1469-445X</issnElectronic><keywords>circadian; feline; Panthera leo; predator; Purkinje; QT</keywords><publishedDay>10</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-10-10</publishedDate><doi>10.1113/ep092203</doi><url/><notes/><college>COLLEGE NANME</college><department>Biosciences Geography and Physics School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BGPS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>Carlsberg Foundation. Grant Number: CF19-0431 Department for Economy Global Challenges Research Fund</funders><projectreference/><lastEdited>2024-10-24T12:30:32.9435059</lastEdited><Created>2024-09-16T13:02:10.8094301</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Biosciences, Geography and Physics - Biosciences</level></path><authors><author><firstname>Frederik S.</firstname><surname>Scharling</surname><order>1</order></author><author><firstname>Ditte‐Mari</firstname><surname>Sandgreen</surname><order>2</order></author><author><firstname>Julia</firstname><surname>Stagegaard</surname><order>3</order></author><author><firstname>Vibeke S.</firstname><surname>Elbrønd</surname><order>4</order></author><author><firstname>Stefano</firstname><surname>Vincenti</surname><order>5</order></author><author><firstname>Jonas L.</firstname><surname>Isaksen</surname><order>6</order></author><author><firstname>Tobias</firstname><surname>Wang</surname><order>7</order></author><author><firstname>Rory</firstname><surname>Wilson</surname><orcid>0000-0003-3177-0177</orcid><order>8</order></author><author><firstname>Richard</firstname><surname>Gunner</surname><order>9</order></author><author><firstname>Nikki</firstname><surname>Marks</surname><order>10</order></author><author><firstname>Stephen H.</firstname><surname>Bell</surname><order>11</order></author><author><firstname>Martin C. van</firstname><surname>Rooyen</surname><order>12</order></author><author><firstname>Nigel C.</firstname><surname>Bennett</surname><order>13</order></author><author><firstname>Daniel W.</firstname><surname>Hart</surname><order>14</order></author><author><firstname>Angela C.</firstname><surname>Daly</surname><order>15</order></author><author><firstname>Mads F.</firstname><surname>Bertelsen</surname><order>16</order></author><author><firstname>D. Michael</firstname><surname>Scantlebury</surname><order>17</order></author><author><firstname>Kirstine</firstname><surname>Calloe</surname><order>18</order></author><author><firstname>Morten B.</firstname><surname>Thomsen</surname><orcid>0000-0002-2469-6458</orcid><order>19</order></author></authors><documents><document><filename>67695__32696__86db3b5831b24b7dbccb4128ea770d02.pdf</filename><originalFilename>67695.VoR.pdf</originalFilename><uploaded>2024-10-24T12:21:07.6605914</uploaded><type>Output</type><contentLength>3094712</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling v2 67695 2024-09-16 Short QT intervals in African lions 017bc6dd155098860945dc6249c4e9bc 0000-0003-3177-0177 Rory Wilson Rory Wilson true false 2024-09-16 BGPS The cardiac conduction system in large carnivores, such as the African lion (Panthera leo), represents a significant knowledge gap in both veterinary science and in cardiac electrophysiology. Short QT intervals have been reported from zoo-kept, anaesthetized lions, and our goal was to record the first ECGs from wild, conscious lions roaming freely, and compare them to zoo-kept lions under the hypothesis that short QT is unique to zoo-kept lions. Macroscopic and histological examinations were performed on heart tissue removed from nine healthy zoo lions. ECGs were recorded from the nine anaesthetized zoo-kept lions, and from 15 anaesthetized and conscious wild lions in Africa. Our histological and topographical description of the lion's heart matched what has previously been published. In conscious lions, the ECG recordings revealed a mean heart rate of 70 ± 4 beats/min, with faster heart rates during the night. PQ and QT intervals were heart rate dependent in the conscious lions. Interestingly, QT intervals recorded in wild lions were markedly longer than QT intervals from zoo lions (398 ± 40 vs. 297 ± 9 ms, respectively; P < 0.0001). Anaesthesia or heart rate did not account for this difference. We provide a comprehensive description of the cardiac anatomy and electrophysiology of wild and zoo-kept lions. QT intervals were significantly shorter in zoo lions, suggesting functional disparities in cardiac electrophysiology between wild and zoo-kept lions, potentially related to physical fitness. These findings underscore the plasticity of cardiac electrophysiology and may be of value when reintroducing endangered species into the wild and when managing lions in human care. Journal Article Experimental Physiology 0 Wiley 0958-0670 1469-445X circadian; feline; Panthera leo; predator; Purkinje; QT 10 10 2024 2024-10-10 10.1113/ep092203 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University Another institution paid the OA fee Carlsberg Foundation. Grant Number: CF19-0431 Department for Economy Global Challenges Research Fund 2024-10-24T12:30:32.9435059 2024-09-16T13:02:10.8094301 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Frederik S. Scharling 1 Ditte‐Mari Sandgreen 2 Julia Stagegaard 3 Vibeke S. Elbrønd 4 Stefano Vincenti 5 Jonas L. Isaksen 6 Tobias Wang 7 Rory Wilson 0000-0003-3177-0177 8 Richard Gunner 9 Nikki Marks 10 Stephen H. Bell 11 Martin C. van Rooyen 12 Nigel C. Bennett 13 Daniel W. Hart 14 Angela C. Daly 15 Mads F. Bertelsen 16 D. Michael Scantlebury 17 Kirstine Calloe 18 Morten B. Thomsen 0000-0002-2469-6458 19 67695__32696__86db3b5831b24b7dbccb4128ea770d02.pdf 67695.VoR.pdf 2024-10-24T12:21:07.6605914 Output 3094712 application/pdf Version of Record true © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Short QT intervals in African lions
spellingShingle Short QT intervals in African lions
Rory Wilson
title_short Short QT intervals in African lions
title_full Short QT intervals in African lions
title_fullStr Short QT intervals in African lions
title_full_unstemmed Short QT intervals in African lions
title_sort Short QT intervals in African lions
author_id_str_mv 017bc6dd155098860945dc6249c4e9bc
author_id_fullname_str_mv 017bc6dd155098860945dc6249c4e9bc_***_Rory Wilson
author Rory Wilson
author2 Frederik S. Scharling
Ditte‐Mari Sandgreen
Julia Stagegaard
Vibeke S. Elbrønd
Stefano Vincenti
Jonas L. Isaksen
Tobias Wang
Rory Wilson
Richard Gunner
Nikki Marks
Stephen H. Bell
Martin C. van Rooyen
Nigel C. Bennett
Daniel W. Hart
Angela C. Daly
Mads F. Bertelsen
D. Michael Scantlebury
Kirstine Calloe
Morten B. Thomsen
format Journal article
container_title Experimental Physiology
container_volume 0
publishDate 2024
institution Swansea University
issn 0958-0670
1469-445X
doi_str_mv 10.1113/ep092203
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description The cardiac conduction system in large carnivores, such as the African lion (Panthera leo), represents a significant knowledge gap in both veterinary science and in cardiac electrophysiology. Short QT intervals have been reported from zoo-kept, anaesthetized lions, and our goal was to record the first ECGs from wild, conscious lions roaming freely, and compare them to zoo-kept lions under the hypothesis that short QT is unique to zoo-kept lions. Macroscopic and histological examinations were performed on heart tissue removed from nine healthy zoo lions. ECGs were recorded from the nine anaesthetized zoo-kept lions, and from 15 anaesthetized and conscious wild lions in Africa. Our histological and topographical description of the lion's heart matched what has previously been published. In conscious lions, the ECG recordings revealed a mean heart rate of 70 ± 4 beats/min, with faster heart rates during the night. PQ and QT intervals were heart rate dependent in the conscious lions. Interestingly, QT intervals recorded in wild lions were markedly longer than QT intervals from zoo lions (398 ± 40 vs. 297 ± 9 ms, respectively; P < 0.0001). Anaesthesia or heart rate did not account for this difference. We provide a comprehensive description of the cardiac anatomy and electrophysiology of wild and zoo-kept lions. QT intervals were significantly shorter in zoo lions, suggesting functional disparities in cardiac electrophysiology between wild and zoo-kept lions, potentially related to physical fitness. These findings underscore the plasticity of cardiac electrophysiology and may be of value when reintroducing endangered species into the wild and when managing lions in human care.
published_date 2024-10-10T12:30:31Z
_version_ 1813794711643619328
score 11.035634

Similar Items