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Residential green environments are associated with human milk oligosaccharide diversity and composition

Mirkka Lahdenperä Orcid Logo, Laura Galante Orcid Logo, Carlos Gonzales-Inca Orcid Logo, Jussi Vahtera Orcid Logo, Jaana Pentti, Samuli Rautava Orcid Logo, Niina Käyhkö Orcid Logo, Chloe Yonemitsu, Julia Gupta, Lars Bode Orcid Logo, Hanna Lagström Orcid Logo

Scientific Reports, Volume: 13, Issue: 1

Swansea University Author: Laura Galante Orcid Logo

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DOI (Published version): 10.1038/s41598-022-27317-1

Abstract

Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between prop...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: Springer Science and Business Media LLC 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa68010
first_indexed 2024-10-18T07:54:45Z
last_indexed 2025-01-09T20:32:22Z
id cronfa68010
recordtype SURis
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spelling 2024-12-20T09:40:13.4227050 v2 68010 2024-10-18 Residential green environments are associated with human milk oligosaccharide diversity and composition d1c6c22f6a863ef2050ed9768566884b 0000-0002-6190-7955 Laura Galante Laura Galante true false 2024-10-18 MEDS Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of the mother’s residential green environment, measured as (1) greenness (Normalized Difference Vegetation index, NDVI), (2) Vegetation Cover Diversity (VCDI) and (3) Naturalness Index (NI), and human milk oligosaccharides (HMOs), known for their immune- and microbiota-related health effects on the infant (N = 795 mothers). We show that HMO diversity increases and concentrations of several individual HMOs and HMO groups change with increased VCDI and NI in residential green environments. This suggests that variation in residential green environments may influence the infant via maternal milk through modified HMO composition. The results emphasize the mediating role of breastfeeding between the residential green environments and health in early life. Journal Article Scientific Reports 13 1 Springer Science and Business Media LLC 2045-2322 5 1 2023 2023-01-05 10.1038/s41598-022-27317-1 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee We would like to thank all the STEPS Study families who took part in the study and mothers who provided milk samples. We are grateful for all the research staff who assisted in the recruitment and data collection. We thank the National Institute of Health (R21-HD088953/L.B.) and the Academy of Finland (grant numbers 329240/J.V. and 321409/H.L.) for funding. Additional funding was received from the Strategic Research Council at the Academy of Finland (grant number 345183 and 345185/M.L.). 2024-12-20T09:40:13.4227050 2024-10-18T08:50:16.2008366 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Mirkka Lahdenperä 0000-0003-0062-6284 1 Laura Galante 0000-0002-6190-7955 2 Carlos Gonzales-Inca 0000-0003-0300-9097 3 Jussi Vahtera 0000-0002-6036-061x 4 Jaana Pentti 5 Samuli Rautava 0000-0003-0935-3593 6 Niina Käyhkö 0000-0003-2482-5085 7 Chloe Yonemitsu 8 Julia Gupta 9 Lars Bode 0000-0002-9914-9571 10 Hanna Lagström 0000-0002-5069-6582 11
title Residential green environments are associated with human milk oligosaccharide diversity and composition
spellingShingle Residential green environments are associated with human milk oligosaccharide diversity and composition
Laura Galante
title_short Residential green environments are associated with human milk oligosaccharide diversity and composition
title_full Residential green environments are associated with human milk oligosaccharide diversity and composition
title_fullStr Residential green environments are associated with human milk oligosaccharide diversity and composition
title_full_unstemmed Residential green environments are associated with human milk oligosaccharide diversity and composition
title_sort Residential green environments are associated with human milk oligosaccharide diversity and composition
author_id_str_mv d1c6c22f6a863ef2050ed9768566884b
author_id_fullname_str_mv d1c6c22f6a863ef2050ed9768566884b_***_Laura Galante
author Laura Galante
author2 Mirkka Lahdenperä
Laura Galante
Carlos Gonzales-Inca
Jussi Vahtera
Jaana Pentti
Samuli Rautava
Niina Käyhkö
Chloe Yonemitsu
Julia Gupta
Lars Bode
Hanna Lagström
format Journal article
container_title Scientific Reports
container_volume 13
container_issue 1
publishDate 2023
institution Swansea University
issn 2045-2322
doi_str_mv 10.1038/s41598-022-27317-1
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of the mother’s residential green environment, measured as (1) greenness (Normalized Difference Vegetation index, NDVI), (2) Vegetation Cover Diversity (VCDI) and (3) Naturalness Index (NI), and human milk oligosaccharides (HMOs), known for their immune- and microbiota-related health effects on the infant (N = 795 mothers). We show that HMO diversity increases and concentrations of several individual HMOs and HMO groups change with increased VCDI and NI in residential green environments. This suggests that variation in residential green environments may influence the infant via maternal milk through modified HMO composition. The results emphasize the mediating role of breastfeeding between the residential green environments and health in early life.
published_date 2023-01-05T02:55:59Z
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score 11.048302

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