Journal article 16 views
Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
Laura Galante 
,
Hanna Lagström ,
Mark H. Vickers ,
Clare M. Reynolds,
Samuli Rautava,
Amber M. Milan ,
David Cameron-Smith ,
Shikha Pundir
,
Hanna Lagström ,
Mark H. Vickers ,
Clare M. Reynolds,
Samuli Rautava,
Amber M. Milan ,
David Cameron-Smith ,
Shikha Pundir
Nutrients, Volume: 12, Issue: 1, Start page: 152
Swansea University Author:
Laura Galante
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.3390/nu12010152
Abstract
While human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining mi...
| Published in: | Nutrients |
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| ISSN: | 2072-6643 |
| Published: |
MDPI AG
2020
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| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa68017 |
| Abstract: |
While human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining milk composition. The present study aimed to investigate the interplay between maternal and infant characteristics in relation to human milk hormonal profile. In total, 501 human milk samples from mothers recruited in the Finnish STEPS cohort study (Steps to the healthy development) were analysed. Pre-pregnancy and pregnancy maternal data, socioeconomic status and infant characteristics at birth were collated. Leptin, adiponectin, insulin-like growth factor-1 and cyclic Glycine-Proline in milk were measured. Multivariate analysis of variance (MANOVA) and linear regression were utilised for statistical analysis. Sex-specific interactions with maternal factors were observed, as the infant sex mediated associations between gestational diabetes and milk adiponectin (p = 0.031), birth-mode and total protein (p = 0.003), maternal education and insulin-like growth factor-1: cyclic Glycine-Proline ratio (p = 0.035). Our results suggest that changes in human milk composition are associated with interactions between maternal and infant characteristics and pathophysiological factors. Future work should expand on these findings and further explore the link between hormonal profiles in human milk and infant outcomes. |
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| Keywords: |
Breastmilk composition; IGF-1; Adiponectin; Leptin; cGP; Protein; Sex-specific milk composition; Gestational diabetes; Body mass index |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This analysis was funded by the Liggins Institute FRDF (Faculty Research Development Fund, grant number 3716954) and University of Auckland Foundation (grant number 3708092). The clinical trial and collection of samples was funded by the Academy of Finland (grants 121569 and 123571). |
| Issue: |
1 |
| Start Page: |
152 |