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Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations

Laura Galante Orcid Logo, Hanna Lagström Orcid Logo, Mark H. Vickers Orcid Logo, Clare M. Reynolds, Samuli Rautava, Amber M. Milan Orcid Logo, David Cameron-Smith Orcid Logo, Shikha Pundir

Nutrients, Volume: 12, Issue: 1, Start page: 152

Swansea University Author: Laura Galante Orcid Logo

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DOI (Published version): 10.3390/nu12010152

Abstract

While human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining mi...

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Published in: Nutrients
ISSN: 2072-6643
Published: MDPI AG 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa68017
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spelling 2024-12-20T13:07:50.4692884 v2 68017 2024-10-18 Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations d1c6c22f6a863ef2050ed9768566884b 0000-0002-6190-7955 Laura Galante Laura Galante true false 2024-10-18 MEDS While human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining milk composition. The present study aimed to investigate the interplay between maternal and infant characteristics in relation to human milk hormonal profile. In total, 501 human milk samples from mothers recruited in the Finnish STEPS cohort study (Steps to the healthy development) were analysed. Pre-pregnancy and pregnancy maternal data, socioeconomic status and infant characteristics at birth were collated. Leptin, adiponectin, insulin-like growth factor-1 and cyclic Glycine-Proline in milk were measured. Multivariate analysis of variance (MANOVA) and linear regression were utilised for statistical analysis. Sex-specific interactions with maternal factors were observed, as the infant sex mediated associations between gestational diabetes and milk adiponectin (p = 0.031), birth-mode and total protein (p = 0.003), maternal education and insulin-like growth factor-1: cyclic Glycine-Proline ratio (p = 0.035). Our results suggest that changes in human milk composition are associated with interactions between maternal and infant characteristics and pathophysiological factors. Future work should expand on these findings and further explore the link between hormonal profiles in human milk and infant outcomes. Journal Article Nutrients 12 1 152 MDPI AG 2072-6643 Breastmilk composition; IGF-1; Adiponectin; Leptin; cGP; Protein; Sex-specific milk composition; Gestational diabetes; Body mass index 6 1 2020 2020-01-06 10.3390/nu12010152 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This analysis was funded by the Liggins Institute FRDF (Faculty Research Development Fund, grant number 3716954) and University of Auckland Foundation (grant number 3708092). The clinical trial and collection of samples was funded by the Academy of Finland (grants 121569 and 123571). 2024-12-20T13:07:50.4692884 2024-10-18T08:58:15.7737802 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Laura Galante 0000-0002-6190-7955 1 Hanna Lagström 0000-0002-5069-6582 2 Mark H. Vickers 0000-0003-4876-9356 3 Clare M. Reynolds 4 Samuli Rautava 5 Amber M. Milan 0000-0002-9559-7326 6 David Cameron-Smith 0000-0002-0144-5816 7 Shikha Pundir 8
title Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
spellingShingle Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
Laura Galante
title_short Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
title_full Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
title_fullStr Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
title_full_unstemmed Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
title_sort Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
author_id_str_mv d1c6c22f6a863ef2050ed9768566884b
author_id_fullname_str_mv d1c6c22f6a863ef2050ed9768566884b_***_Laura Galante
author Laura Galante
author2 Laura Galante
Hanna Lagström
Mark H. Vickers
Clare M. Reynolds
Samuli Rautava
Amber M. Milan
David Cameron-Smith
Shikha Pundir
format Journal article
container_title Nutrients
container_volume 12
container_issue 1
container_start_page 152
publishDate 2020
institution Swansea University
issn 2072-6643
doi_str_mv 10.3390/nu12010152
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Public Health{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Public Health
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description While human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining milk composition. The present study aimed to investigate the interplay between maternal and infant characteristics in relation to human milk hormonal profile. In total, 501 human milk samples from mothers recruited in the Finnish STEPS cohort study (Steps to the healthy development) were analysed. Pre-pregnancy and pregnancy maternal data, socioeconomic status and infant characteristics at birth were collated. Leptin, adiponectin, insulin-like growth factor-1 and cyclic Glycine-Proline in milk were measured. Multivariate analysis of variance (MANOVA) and linear regression were utilised for statistical analysis. Sex-specific interactions with maternal factors were observed, as the infant sex mediated associations between gestational diabetes and milk adiponectin (p = 0.031), birth-mode and total protein (p = 0.003), maternal education and insulin-like growth factor-1: cyclic Glycine-Proline ratio (p = 0.035). Our results suggest that changes in human milk composition are associated with interactions between maternal and infant characteristics and pathophysiological factors. Future work should expand on these findings and further explore the link between hormonal profiles in human milk and infant outcomes.
published_date 2020-01-06T20:48:23Z
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