Journal article 21 views
Glucocorticoids in preterm human milk
Mariana Muelbert,
Tanith Alexander,
Mark H. Vickers,
Jane E. Harding,
Laura Galante 
,
Frank H. Bloomfield,
(the DIAMOND study group)
,
Frank H. Bloomfield,
(the DIAMOND study group)
Frontiers in Nutrition, Volume: 9
Swansea University Author:
Laura Galante
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.3389/fnut.2022.965654
Abstract
Background: Glucocorticoids (GCs), cortisol and cortisone, are essential regulators of many physiological responses, including immunity, stress and mammary gland function. GCs are present in human milk (HM), but whether maternal and infant factors are associated with HM GC concentration following pr...
| Published in: | Frontiers in Nutrition |
|---|---|
| ISSN: | 2296-861X |
| Published: |
Frontiers Media SA
2022
|
| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa68011 |
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2025-01-09T20:32:22Z |
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<?xml version="1.0"?><rfc1807><datestamp>2024-12-20T11:37:16.4950427</datestamp><bib-version>v2</bib-version><id>68011</id><entry>2024-10-18</entry><title>Glucocorticoids in preterm human milk</title><swanseaauthors><author><sid>d1c6c22f6a863ef2050ed9768566884b</sid><ORCID>0000-0002-6190-7955</ORCID><firstname>Laura</firstname><surname>Galante</surname><name>Laura Galante</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-10-18</date><deptcode>MEDS</deptcode><abstract>Background: Glucocorticoids (GCs), cortisol and cortisone, are essential regulators of many physiological responses, including immunity, stress and mammary gland function. GCs are present in human milk (HM), but whether maternal and infant factors are associated with HM GC concentration following preterm birth is unclear.Materials and methods: HM samples were collected on postnatal day 5 and 10 and at 4 months’ corrected age (4m CA) in a cohort of moderate- and late-preterm infants. GCs in HM were measured by liquid chromatography-tandem mass spectrometry. Relationships between GCs in HM and both maternal and infant characteristics were investigated using Spearman’s correlations and linear mixed models.Results: 170 mothers of 191 infants provided 354 HM samples. Cortisol concentrations in HM increased from postnatal day 5–4m CA (mean difference [MD] 0.6 ± 0.1 ng/ml, p < 0.001). Cortisone concentration did not change across lactation but was higher than cortisol throughout. Compared to no antenatal corticosteroid (ANS), a complete course of ANS was associated with lower GC concentrations in HM through to 4m CA (cortisol: MD –0.3 ± 0.1 ng/ml, p < 0.01; cortisone MD –1.8 ± 0.4 ng/ml, p < 0.001). At 4m CA, higher maternal perceived stress was negatively associated with GC concentrations in HM (cortisol adjusted beta-coefficient [aβ] –0.01 ± 0.01 ng/ml, p = 0.05; and cortisone aβ –0.1 ± 0.03 ng/ml, p = 0.01), whereas higher postpartum depression and maternal obesity were associated with lower cortisone concentrations (aβ –0.1 ± 0.04 ng/ml p < 0.05; MD [healthy versus obese] –0.1 ± 0.04 ng/ml p < 0.05, respectively). There was a weak positive correlation between GC concentrations in HM and gestational age at birth (r = 0.1, p < 0.05). Infant birth head circumference z-score was negatively associated with cortisol concentrations (aβ –0.01 ± 0.04 ng/ml, p < 0.05). At hospital discharge, fat-free mass showed a weak positive correlation with cortisol concentrations (r = 0.2, p = 0.03), while fat mass showed a weak negative correlation with cortisone concentrations (r = –0.25, p < 0.001).Conclusion: The mammary gland appears to protect the infant from cortisol through inactivation into cortisone. Maternal and infant characteristics were associated with concentration of GCs in HM, including ANS, stress and depression scores, obesity, gestational age and infant size. The effects of HM glucocorticoids on long-term health outcomes requires further research.</abstract><type>Journal Article</type><journal>Frontiers in Nutrition</journal><volume>9</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Frontiers Media SA</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2296-861X</issnElectronic><keywords/><publishedDay>27</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-09-27</publishedDate><doi>10.3389/fnut.2022.965654</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>The DIAMOND trial was funded by the Health
Research Council of New Zealand (16/605) and Counties
Manukau Health (269).</funders><projectreference/><lastEdited>2024-12-20T11:37:16.4950427</lastEdited><Created>2024-10-18T08:55:48.6756986</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Public Health</level></path><authors><author><firstname>Mariana</firstname><surname>Muelbert</surname><order>1</order></author><author><firstname>Tanith</firstname><surname>Alexander</surname><order>2</order></author><author><firstname>Mark H.</firstname><surname>Vickers</surname><order>3</order></author><author><firstname>Jane E.</firstname><surname>Harding</surname><order>4</order></author><author><firstname>Laura</firstname><surname>Galante</surname><orcid>0000-0002-6190-7955</orcid><order>5</order></author><author><firstname>Frank H.</firstname><surname>Bloomfield</surname><order>6</order></author><author><firstname>(the DIAMOND study</firstname><surname>group)</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807> |
| spelling |
2024-12-20T11:37:16.4950427 v2 68011 2024-10-18 Glucocorticoids in preterm human milk d1c6c22f6a863ef2050ed9768566884b 0000-0002-6190-7955 Laura Galante Laura Galante true false 2024-10-18 MEDS Background: Glucocorticoids (GCs), cortisol and cortisone, are essential regulators of many physiological responses, including immunity, stress and mammary gland function. GCs are present in human milk (HM), but whether maternal and infant factors are associated with HM GC concentration following preterm birth is unclear.Materials and methods: HM samples were collected on postnatal day 5 and 10 and at 4 months’ corrected age (4m CA) in a cohort of moderate- and late-preterm infants. GCs in HM were measured by liquid chromatography-tandem mass spectrometry. Relationships between GCs in HM and both maternal and infant characteristics were investigated using Spearman’s correlations and linear mixed models.Results: 170 mothers of 191 infants provided 354 HM samples. Cortisol concentrations in HM increased from postnatal day 5–4m CA (mean difference [MD] 0.6 ± 0.1 ng/ml, p < 0.001). Cortisone concentration did not change across lactation but was higher than cortisol throughout. Compared to no antenatal corticosteroid (ANS), a complete course of ANS was associated with lower GC concentrations in HM through to 4m CA (cortisol: MD –0.3 ± 0.1 ng/ml, p < 0.01; cortisone MD –1.8 ± 0.4 ng/ml, p < 0.001). At 4m CA, higher maternal perceived stress was negatively associated with GC concentrations in HM (cortisol adjusted beta-coefficient [aβ] –0.01 ± 0.01 ng/ml, p = 0.05; and cortisone aβ –0.1 ± 0.03 ng/ml, p = 0.01), whereas higher postpartum depression and maternal obesity were associated with lower cortisone concentrations (aβ –0.1 ± 0.04 ng/ml p < 0.05; MD [healthy versus obese] –0.1 ± 0.04 ng/ml p < 0.05, respectively). There was a weak positive correlation between GC concentrations in HM and gestational age at birth (r = 0.1, p < 0.05). Infant birth head circumference z-score was negatively associated with cortisol concentrations (aβ –0.01 ± 0.04 ng/ml, p < 0.05). At hospital discharge, fat-free mass showed a weak positive correlation with cortisol concentrations (r = 0.2, p = 0.03), while fat mass showed a weak negative correlation with cortisone concentrations (r = –0.25, p < 0.001).Conclusion: The mammary gland appears to protect the infant from cortisol through inactivation into cortisone. Maternal and infant characteristics were associated with concentration of GCs in HM, including ANS, stress and depression scores, obesity, gestational age and infant size. The effects of HM glucocorticoids on long-term health outcomes requires further research. Journal Article Frontiers in Nutrition 9 Frontiers Media SA 2296-861X 27 9 2022 2022-09-27 10.3389/fnut.2022.965654 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee The DIAMOND trial was funded by the Health Research Council of New Zealand (16/605) and Counties Manukau Health (269). 2024-12-20T11:37:16.4950427 2024-10-18T08:55:48.6756986 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Public Health Mariana Muelbert 1 Tanith Alexander 2 Mark H. Vickers 3 Jane E. Harding 4 Laura Galante 0000-0002-6190-7955 5 Frank H. Bloomfield 6 (the DIAMOND study group) 7 |
| title |
Glucocorticoids in preterm human milk |
| spellingShingle |
Glucocorticoids in preterm human milk Laura Galante |
| title_short |
Glucocorticoids in preterm human milk |
| title_full |
Glucocorticoids in preterm human milk |
| title_fullStr |
Glucocorticoids in preterm human milk |
| title_full_unstemmed |
Glucocorticoids in preterm human milk |
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Glucocorticoids in preterm human milk |
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d1c6c22f6a863ef2050ed9768566884b |
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d1c6c22f6a863ef2050ed9768566884b_***_Laura Galante |
| author |
Laura Galante |
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Mariana Muelbert Tanith Alexander Mark H. Vickers Jane E. Harding Laura Galante Frank H. Bloomfield (the DIAMOND study group) |
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Frontiers in Nutrition |
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9 |
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2022 |
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Swansea University |
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10.3389/fnut.2022.965654 |
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Frontiers Media SA |
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Background: Glucocorticoids (GCs), cortisol and cortisone, are essential regulators of many physiological responses, including immunity, stress and mammary gland function. GCs are present in human milk (HM), but whether maternal and infant factors are associated with HM GC concentration following preterm birth is unclear.Materials and methods: HM samples were collected on postnatal day 5 and 10 and at 4 months’ corrected age (4m CA) in a cohort of moderate- and late-preterm infants. GCs in HM were measured by liquid chromatography-tandem mass spectrometry. Relationships between GCs in HM and both maternal and infant characteristics were investigated using Spearman’s correlations and linear mixed models.Results: 170 mothers of 191 infants provided 354 HM samples. Cortisol concentrations in HM increased from postnatal day 5–4m CA (mean difference [MD] 0.6 ± 0.1 ng/ml, p < 0.001). Cortisone concentration did not change across lactation but was higher than cortisol throughout. Compared to no antenatal corticosteroid (ANS), a complete course of ANS was associated with lower GC concentrations in HM through to 4m CA (cortisol: MD –0.3 ± 0.1 ng/ml, p < 0.01; cortisone MD –1.8 ± 0.4 ng/ml, p < 0.001). At 4m CA, higher maternal perceived stress was negatively associated with GC concentrations in HM (cortisol adjusted beta-coefficient [aβ] –0.01 ± 0.01 ng/ml, p = 0.05; and cortisone aβ –0.1 ± 0.03 ng/ml, p = 0.01), whereas higher postpartum depression and maternal obesity were associated with lower cortisone concentrations (aβ –0.1 ± 0.04 ng/ml p < 0.05; MD [healthy versus obese] –0.1 ± 0.04 ng/ml p < 0.05, respectively). There was a weak positive correlation between GC concentrations in HM and gestational age at birth (r = 0.1, p < 0.05). Infant birth head circumference z-score was negatively associated with cortisol concentrations (aβ –0.01 ± 0.04 ng/ml, p < 0.05). At hospital discharge, fat-free mass showed a weak positive correlation with cortisol concentrations (r = 0.2, p = 0.03), while fat mass showed a weak negative correlation with cortisone concentrations (r = –0.25, p < 0.001).Conclusion: The mammary gland appears to protect the infant from cortisol through inactivation into cortisone. Maternal and infant characteristics were associated with concentration of GCs in HM, including ANS, stress and depression scores, obesity, gestational age and infant size. The effects of HM glucocorticoids on long-term health outcomes requires further research. |
| published_date |
2022-09-27T20:48:21Z |
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11.048302 |