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The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
Robert J H Miller,
Mark Lemley,
Aakash Shanbhag,
Giselle Ramirez,
Joanna X Liang,
Valerie Builoff,
Paul Kavanagh,
Tali Sharir,
M Timothy Hauser,
Terrence D Ruddy,
Mathews B Fish,
Timothy M Bateman,
Wanda Acampa,
Andrew J Einstein,
Sharmila Dorbala,
Marcelo F Di Carli,
Attila Feher,
Edward J Miller,
Albert J Sinusas,
Julian Halcox 
,
Monica Casanova da Silva Martins,
Philipp A Kaufmann,
Damini Dey,
Daniel S Berman,
Piotr J Slomka
,
Monica Casanova da Silva Martins,
Philipp A Kaufmann,
Damini Dey,
Daniel S Berman,
Piotr J Slomka
Journal of Nuclear Medicine
Swansea University Authors:
Julian Halcox , Monica Casanova da Silva Martins
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.2967/jnumed.124.268292
Abstract
The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. The updated REFINE SPECT is a multicenter, international...
| Published in: | Journal of Nuclear Medicine |
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| ISSN: | 0161-5505 2159-662X |
| Published: |
Society of Nuclear Medicine and Molecular Imaging
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa68025 |
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| Abstract: |
The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5-4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23-2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56-4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101-400 (unadjusted HR, 3.09; 95% CI, 2.57-3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41-6.05) were at increased risk of MACEs. The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging. [Abstract copyright: © 2024 by the Society of Nuclear Medicine and Molecular Imaging.] |
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| Item Description: |
Research Article, Clinical Investigation |
| Keywords: |
SPECT, solid-state detector, myocardial perfusion imaging, coronary artery disease, artificial intelligence, quantitative analysis |
| College: |
Faculty of Medicine, Health and Life Sciences |